A5039990053- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Protein Structure and Dynamics
- Bacillus and Francisella bacterial research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Virology and Viral Diseases
State Research Center of Virology and Biotechnology VECTOR
2022-2024
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2023
The aim of the study is an in silico modeling avian influenza A/H5N8 virus neuraminidase and zanamivir interaction using homology molecular docking. A/chicken/Tatarstan/88/2017 (wild type) A/chicken/Tatarstan/112/2017 (N294S mutation) strains with complexes were considered. structures two obtained analysed.Homology docking provides information about inhibitors affinity. data can be used for further investigation to determine elucidate possible mechanisms resistance.
Currently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic A(H5N1) clade 2.3.4.4b reassortant have become predominant the world caused multiple infections mammals. It was shown that some of mostly isolated from mammals contain an E627K mutation PB2 protein which can lead adaptation mammalian cells. In 2023 Russia we two birds one contained protein. This virus had increased virulence mice. Limited airborne...
The WHO has developed a tool to assess the risk of newly emerging influenza viruses with pandemic potential (TIPRA). According TIPRA, main parameters for assessing human-to-human transmission novel virus are its ability bind human cell receptors upper respiratory tract (URT) and transmit in model animals. aim this study was quantify airborne animal ferret model. studied an aerobiology chamber. Airborne particles concentration fractional composition chamber were measured using aerosol...
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after start COVID-19 pandemic and implementation mitigation strategies. virus reemerged 2021–2022 with global spread new genetic clade 3C.2a1b.2a.2 A(H3N2) viruses. purpose this study to characterize viruses season Russia analyze receptor specificity properties Clinical samples were collected at local Sanitary-and-Epidemiological Centers Rospotrebnadzor. Whole genome sequencing performed using NGS....
In Russia, during the COVID-19 pandemic, a decrease in influenza circulation was initially observed. Influenza re-emerged with dominance of new clades A(H3N2) viruses 2021-2022 and A(H1N1)pdm09 2022-2023. this study, we aimed to characterize 2022-2023 season as well investigate HA-D222G/N polymorphism associated increased disease severity. PCR testing 780 clinical specimens showed 72.2% them be positive for A(H1N1)pdm09, 2.8% A(H3N2), 25% B viruses. The majority analyzed belonged newly...
Scientific relevance . The use of recombinant antigens in vaccine production is limited because vaccines based on such tend to have low immunogenicity. However, a COVID-19 that combines SARS-CoV-2 spike glycoprotein as its antigen and virus-like immune-stimulating complexes (ISCOMs) adjuvant (Nuvaxovid) induces protective virus-neutralising response. State Research Center Virology Biotechnology “Vector” (hereinafter, Vector) has developed the ISCOM Matrix-V, which plays key role inducing...