A5046343838- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Virology and Viral Diseases
- vaccines and immunoinformatics approaches
- Nanowire Synthesis and Applications
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Mechanical and Optical Resonators
- COVID-19 epidemiological studies
- Insect symbiosis and bacterial influences
- Influenza Virus Research Studies
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- Respiratory viral infections research
- Zoonotic diseases and public health
- Advanced MEMS and NEMS Technologies
State Research Center of Virology and Biotechnology VECTOR
2015-2025
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2015-2022
Vaccination of the population is one most effective countermeasures in responding to pandemic caused by novel coronavirus infection. Therefore, scientists all over world have been working develop and safe vaccines. We developed a synthetic peptide vaccine, EpiVacCorona, against SARS-CoV-2 coronavirus, which suspension for intramuscular administration containing composition chemically synthesized immunogens S protein conjugated carrier adsorbed on aluminum hydroxide. Phase I–II clinical...
Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized peptides conjugated carrier protein and adsorbed aluminum hydroxide studied specific activity...
The State Research Center of Virology and Biotechnology "VECTOR" the Federal Service for Oversight Consumer Protection Welfare (Rospotrebnadzor) has developed peptide-based EpiVacCorona vaccine, which is first synthetic antiviral vaccine mass immunization in international vaccinology. An early clinical trial (Phase I-II) demonstrated that a safe product. "Multicenter double-blind, placebo-controlled, comparative, randomized to assess tolerability, safety, immunogenicity prophylactic efficacy...
Puumala virus ( Orthohantavirus puumalaense ) is one of the causative agents hemorrhagic fever with renal syndrome (HFRS), which widespread in Russian Federation (RF): more than 6 thousand cases HFRS infection are registered annually, over past decade (2013–2023) – 77 disease were reported. causes up to 98 % cases. The development rapid and highly accurate diagnostic methods, including serological test systems, great importance clinical laboratory studies aimed at controlling viral...
The current unprecedented outbreak of Ebola virus (EBOV) disease in West Africa has demonstrated the urgent need for a vaccine. Here, we describe evaluation an EBOV vaccine candidate based on Kunjin replicon virus-like particles (KUN VLPs) encoding glycoprotein with D637L mutation (GP/D637L) nonhuman primates. Four African green monkeys (Cercopithecus aethiops) were injected subcutaneously dose 109 KUN VLPs per animal twice interval 4 weeks, and animals challenged 3 weeks later...
The spread of the monkeypox virus infection among humans in many countries outside Africa, which started 2022, is now drawing attention medical and scientific communities to fact that immunization against this sorely needed. According current guidelines, people with first-generation smallpox vaccine based on vaccinia (VACV) LIVP strain, licensed Russia, should be performed via transepidermal inoculation (skin scarification, s.s.). However, long past experience using vaccination technique...
Abstract Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration the over 5 days to cynomolgus macaques infected 24 hours previously lethal dose virus suppressed viral loads more than logs and protected animals mortality. Animals generated their own glycoprotein-specific responses 9–15 after infection, circulating undetectable day...
The mass smallpox vaccination campaign has played a crucial role in eradication. Various strains of the vaccinia virus (VACV) were used as live vaccine different countries, their origin being unknown most cases. VACV differ terms pathogenicity exhibited upon inoculation laboratory animals and reactogenicity humans. Therefore, each generated strain or clonal variant needs to be thoroughly studied vivo systems. 14 LIVP (LIVP-14) was study object this work. A comparative analysis virulence...
The vaccinia virus (VACV) has been used for prophylactic immunization against smallpox many decades. However, the VACV-based vaccine had highly reactogenic. Therefore, after eradication of smallpox, World Health Organization in 1980 recommended that vaccination this infection be discontinued. As a result, there rise occurrence orthopoxvirus infections humans recent years, with most severe being 2022 monkeypox epidemic reached all continents. Thus, it is crucial to address pressing matter...
The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there a demand for designing VACV variants possessing enhanced immunogenicity, making possible to reduce dose and, therefore, significantly eliminate pathogenic effect of body. In this study, we analyzed development humoral and T cell-mediated immune responses elicited by immunizing mice with low-dose carrying mutant A34R gene (which increases...
The monkeypox epidemic, which became unusually widespread among humans in 2022, has brought awareness about the necessity of smallpox vaccination patients risk groups. modern vaccine variants are introduced either intramuscularly or by skin scarification. Intramuscular cannot elicit an active immune response, since tissues at site immunologically poor. Skin evolved into important organ mammals; therefore, intradermal delivery a can ensure reliable protective immunity. Historically,...
Mass vaccination has played a critical role in the global eradication of smallpox. Various vaccinia virus (VACV) strains, whose origin not been clearly documented most cases, have used as live vaccines different countries. These VACV strains differed pathogenicity towards various laboratory animals and reactogenicity exhibited upon humans. In this work, we studied development humoral cellular immune responses BALB/c mice inoculated intranasally (i.n.) or intradermally (i.d.) with LIVP strain...
The modern approach to developing attenuated smallpox vaccines usually consists in targeted inactivation of vaccinia virus (VACV) virulence genes. In this work, we studied how an elevated production extracellular enveloped virions (EEVs) and the route mouse infection can influence immunogenicity VACV. research subject was LIVP strain, which is used Russia for vaccination. Two point mutations causing EEVs compared with parental strain were inserted into sequence VACV A34R gene. created mutant...
Yellow fever (YF) remains one of the most common natural focal infectious diseases in world. In connection with increasing tourist flow to countries endemic for YF, discovery stable populations Aedes aegypti and Ae. albopictus which are main vectors yellow virus (YFV), southern regions Russia, fact that medical institutions our country it is possible obtain a live attenuated vaccine against but there no way evaluate effectiveness vaccination, question arises development implementation...
Vaccinia virus had played a key role in the global smallpox eradication. However, case of mass vaccination with various strains severe side effects were revealed sometimes ending up lethal outcomes, especially immunocompromised humans. Hence, 1980 World Health Organization recommended to cancel after declaring about Over last 40 years, human population virtually lost immunity not only against smallpox, but also other zoonotic orthopoxvirus infections, such as monkeypox, cowpox, buffalopox,...
The aim of the work was to develop a kit for detection IgM and IgG antibodies Ebola virus in ELISA. Materials methods. strain Zaire H.sapiens-wt/GIN/2015/Kalidie-Kindia-1022 grown on cell culture used as antigen. Results conclusions. by Rospotrebnadzor SAET team its Guinea while investigating cases during fever epidemics. It established that specific persisted survivors 2 years. Application this laboratory diagnostics permits ELISA become main confirmatory method detection.
The aim of the work was to detect specific antibodies West Nile, dengue, CCHF, and chikungunya viruses in blood sera Guinean Kindia Province residents. Materials methods. obtained were analyzed ELISA discover IgG abovementioned viruses. Results conclusions. Detected 267 (82 %) positive samples out 326, containing immunoglobulins G class these arboviruses. data provide evidence for active circulation dengue Nile fevers agents this territory. Further studies immune strata population, possible...
The aim of the study was in differential specific diagnosis viral infections unknown etiology patients who have recently returned from a trip to countries Southeast Asia and India. In 2013, SRC VB "Vector" examined single serum samples 131 with suspected Dengue Fever. RNA detected by means polymerase chain reaction, NS dengue virus antigen antibody classes M G - use immunochromatographic methods enzyme immunoassay. same sera presence IgM measles, rubella cytomegalovirus revealed immunoassay...