A5028271423- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
State Research Center of Virology and Biotechnology VECTOR
2019-2022
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2021-2022
Vaccination of the population is one most effective countermeasures in responding to pandemic caused by novel coronavirus infection. Therefore, scientists all over world have been working develop and safe vaccines. We developed a synthetic peptide vaccine, EpiVacCorona, against SARS-CoV-2 coronavirus, which suspension for intramuscular administration containing composition chemically synthesized immunogens S protein conjugated carrier adsorbed on aluminum hydroxide. Phase I–II clinical...
Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized peptides conjugated carrier protein and adsorbed aluminum hydroxide studied specific activity...
The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One main models for pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to virus. Herein, we report SARS-CoV-2 infection in transgenic mice conditionally expressing human ACE2 (hACE2), with a focus on viral distribution after intranasal inoculation. Transgenic carrying hACE2 under floxed STOP cassette [(hACE2-LoxP(STOP)] were mated two types Cre-ERT2 strains...
The aim was to analyze heard immunity against influenza viruses as well severe course of infection prior the 2019–2020 epidemic season. Methods. Blood sera samples were collected and after conducting population-wide vaccination campaign at sanitary epidemiological centers in different regions Russian Federation Siberian Federal District, respectively. Sera tested by using hemagglutination inhibition (HI) assay with vaccine strains A/Brisbane/02/2018 (H1N1)pdm09, A/Kansas/14/2017 (H3N2),...
Aim. Evaluation of herd immunity prior to the 2017-2018 influenza season, and characterization viruses isolated from severe or fatal cases in people vaccinated fall 2017. Materials methods. hemagglutination inhibition assay. Isolation viruses. Antigenic genetic analysis. Results. Prior epidemic season 33-47% blood sera samples collected on territory Russia showed presence protective antibody titers against vaccine strains A, 24-30% — B/Victoria. During 87 A B were isolated. A(H1N1)pdm09...