A5068316663- Poxvirus research and outbreaks
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Plant Virus Research Studies
- vaccines and immunoinformatics approaches
- Bacterial Genetics and Biotechnology
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Outbreaks Research
- Nanowire Synthesis and Applications
- RNA Interference and Gene Delivery
- Geological Studies and Exploration
- Hepatitis B Virus Studies
- Mining and Gasification Technologies
- Biopolymer Synthesis and Applications
- Vector-borne infectious diseases
- Rabies epidemiology and control
State Research Center of Virology and Biotechnology VECTOR
2013-2023
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2020-2023
Rosneft (Russia)
2019-2020
Pirogov Russian National Research Medical University
1996
Vaccination of the population is one most effective countermeasures in responding to pandemic caused by novel coronavirus infection. Therefore, scientists all over world have been working develop and safe vaccines. We developed a synthetic peptide vaccine, EpiVacCorona, against SARS-CoV-2 coronavirus, which suspension for intramuscular administration containing composition chemically synthesized immunogens S protein conjugated carrier adsorbed on aluminum hydroxide. Phase I–II clinical...
This study presents the isolation of influenza A(H5N8) virus clade 2.3.4.4b from a poultry worker during an outbreak highly pathogenic avian among chickens at farm in Astrakhan, Russia December 2020. Nasopharyngeal swabs collected seven workers were positive for A(H5N8), as confirmed by RT-PCR and sequencing. The was isolated one human specimens characterised. Sporadic A(H5)2.3.4.4. infections represent possible concern public health.
Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized peptides conjugated carrier protein and adsorbed aluminum hydroxide studied specific activity...
The State Research Center of Virology and Biotechnology "VECTOR" the Federal Service for Oversight Consumer Protection Welfare (Rospotrebnadzor) has developed peptide-based EpiVacCorona vaccine, which is first synthetic antiviral vaccine mass immunization in international vaccinology. An early clinical trial (Phase I-II) demonstrated that a safe product. "Multicenter double-blind, placebo-controlled, comparative, randomized to assess tolerability, safety, immunogenicity prophylactic efficacy...
In this study, we investigated the features of infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro vivo. The determination activity viruses digital PCR demonstrated that during simultaneous sequential HAdV-5 followed infection vivo, does not interfere replication SARS-CoV-2. hamsters co-infected mono-infected exhibited nearly identical viral titers loads lungs. ferrets SARS-CoV-2- IAV more pronounced clinical...
This paper describes the current situation on highly pathogenic avian influenza virus in 2022 and provides forecast of possible further spread Russia. In 2022, circulation a wide variety subtypes, which have epizootiological epidemiological significance, was recorded world. Outbreaks caused by were reported over 60 countries. addition, human infections with viruses A(H5Nx) A(H9N2) subtypes registered. There large-scale epizootic affected more than 10 regions European part Russia Russian Far...
The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One main models for pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to virus. Herein, we report SARS-CoV-2 infection in transgenic mice conditionally expressing human ACE2 (hACE2), with a focus on viral distribution after intranasal inoculation. Transgenic carrying hACE2 under floxed STOP cassette [(hACE2-LoxP(STOP)] were mated two types Cre-ERT2 strains...
The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the hemagglutination inhibition assay, performed characterization of viruses isolated from severe or fatal cases people vaccinated fall 2017. During season, 87 A B were 75 cases, including selected viral isolates analyzed directly original clinical material, genetically characterized. A(H1N1)pdm09 belonged clade 6B.1, B/Yamagata-like 3,...
The WHO has developed a tool to assess the risk of newly emerging influenza viruses with pandemic potential (TIPRA). According TIPRA, main parameters for assessing human-to-human transmission novel virus are its ability bind human cell receptors upper respiratory tract (URT) and transmit in model animals. aim this study was quantify airborne animal ferret model. studied an aerobiology chamber. Airborne particles concentration fractional composition chamber were measured using aerosol...
The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the have fabricated based on silicon-on-insulator structures (SOI chip), using complementary metal-oxide-semiconductor (CMOS)-compatible technology—by means gas-phase etching and standard optical photolithography. surface SOI chip contains matrix 10 (NR) sensor elements. chips n-type conductance used this study. For biospecific target particles, antibodies against virus covalently...
In this study, we investigated recent sheep pox outbreaks that occurred in Ononsky and Borzunsky regions of Zabajkalskij kray Russia. The involved 2756 animals which 112 were infected 3 slaughtered. Samples injured skin analysed by electron microscopy CaPV-specific P32 gene amplification. Following sequence analysis entire showed both specimens identical to the several poxvirus isolates from China India. close location last decade's Russian suggest possible future Russia could occur along...
In 2016–2017, several outbreaks among wild and domestic birds caused by highly pathogenic influenza virus were recorded in the territory of Russian Federation. After isolation A (H5N8) Republic Tyva May 2016, was introduced into west birds, where it a massive epizootic. The death agricultural poultry noted regions European part Russia epizootics continued until end 2017. This paper presents data on circulation over past two years. current status regarding H5 Federation is also considered,...
Analyzed was modern epidemiological situation on highly pathogenic avian flu in 2018. Prognosis for possible further distribution of viruses the territory Russia made. In 2018, challenging. This due to spread clade 2.3.4.4, which caused multiple outbreaks among wild birds and poultry European part Russia. addition, A/H5N6 influenza virus circulation first time detected Saratov Region during routine surveillance. May, 2018 two different lineages A/H9N2 were isolated that occurred at several...
SARS-CoV-2, which emerged in Wuhan (China), has become a great worldwide problem 2020 and led to more than 1,000,000 deaths worldwide. Many laboratories are searching for ways fight this pandemic. We studied the action of cellular antiviral protein tetherin, is encoded by BST2 gene. deleted transmembrane domain-encoding part gene Vero cell line. The domain target virus-antagonizing proteins. showed decrease SARS-CoV-2 cells with domains compared initial Similar results were obtained SARS-CoV...
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after start COVID-19 pandemic and implementation mitigation strategies. virus reemerged 2021–2022 with global spread new genetic clade 3C.2a1b.2a.2 A(H3N2) viruses. purpose this study to characterize viruses season Russia analyze receptor specificity properties Clinical samples were collected at local Sanitary-and-Epidemiological Centers Rospotrebnadzor. Whole genome sequencing performed using NGS....
Outbreaks of influenza, which is a contagious respiratory disease, occur throughout the world annually, affecting millions people with many fatal cases. The D222G/N mutations in hemagglutinin (HA) gene A(H1N1)pdm09 are associated severe and human influenza These lead to increased virus replication lower tract (LRT) may result life-threatening pneumonia. Targeted NGS analysis revealed presence major minor variants 57% cases, proportion viral varying from 1% 98% each individual sample epidemic...