A5064227178- Viral Infectious Diseases and Gene Expression in Insects
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Transgenic Plants and Applications
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Immune responses and vaccinations
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Tissue Engineering and Regenerative Medicine
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA and protein synthesis mechanisms
- Erythropoietin and Anemia Treatment
- Space exploration and regulation
- Second Language Acquisition and Learning
- RNA Research and Splicing
- Inhalation and Respiratory Drug Delivery
State Research Center of Virology and Biotechnology VECTOR
2006-2023
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2021
Omsk State Agrarian University
2020
Vaccination of the population is one most effective countermeasures in responding to pandemic caused by novel coronavirus infection. Therefore, scientists all over world have been working develop and safe vaccines. We developed a synthetic peptide vaccine, EpiVacCorona, against SARS-CoV-2 coronavirus, which suspension for intramuscular administration containing composition chemically synthesized immunogens S protein conjugated carrier adsorbed on aluminum hydroxide. Phase I–II clinical...
Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized peptides conjugated carrier protein and adsorbed aluminum hydroxide studied specific activity...
The State Research Center of Virology and Biotechnology "VECTOR" the Federal Service for Oversight Consumer Protection Welfare (Rospotrebnadzor) has developed peptide-based EpiVacCorona vaccine, which is first synthetic antiviral vaccine mass immunization in international vaccinology. An early clinical trial (Phase I-II) demonstrated that a safe product. "Multicenter double-blind, placebo-controlled, comparative, randomized to assess tolerability, safety, immunogenicity prophylactic efficacy...
Development of delivery antigens and antigenic complexes using microcapsules or microgranules made pH-dependent polymers is one several high priority directions modern vaccinology. These should protect the virus from acid gastric medium, dissolve swell readily in weakly alkaline intestinal no way decrease specific activities viral antigens, promote their penetration into mucosa, possess adjuvant properties. The State Research Center Vector "DELSI" are developing technology for production...
Background The threat of pandemic A/H1N1 influenza remains a matter considerable public concern. Recent outbreaks underline the importance rapid production reserve vaccine sufficient for and interpandemic periods. Traditional vaccines intended seasonal do not satisfy this demand, because they are unable to induce cross-reactive antibodies flu. Live made in cell culture offer potential advantages it is possible produce amount these over short period. Their use eliminate concerns about...
The morphological and functional condition of biological membranes cells their resistance while exposed to high temperature 41 0 С for 180 minutes were studied in this research.The damaging effect exogenous hyperthermic pressure was corrected by the preliminary administration antioxidants unitiol à-tocopherol.Malondialdehyde blood serum researched as content final product lipid peroxidation.Indicators cell experimental animals evaluated.The osmotic leukocytes erythrocytes, indicatos...
Background Live influenza vaccines trigger all major components of the anti-flu immune response machinery and have been included in global WHO program on pandemic preparedness. Key advantages using live include a feasibility intranasal administration, opportunity to rapidly scale up production viral substance, simplicity vaccination, robust protection against antigenic drift variants virus. Use certified cell cultures for cultivation seasonal strains along with biodegradable materials...
Cancer cells attractive and activate many non-tumoral cells, including bone marrow-derived as a result stimulate migration of this cells. Many studies demonstrate that tumor causes active redistribution marrow during specific stages cancer progression metastasis. However, to date how the derived at primary sites is hijacked support growth influence distribution not understood. The most complete picture impact development on required better understanding process forming microenvironment....
Mesenchymal stem cells or multipotent mesenchymal stromal (MSCs) are progenitor used to function as cellular delivery vehicles for antitumor agents (Miletic et al., 2007; Gunnarsson 2010; van Eekelen Studeny 2002). The use of the anticancer drugs based on hypothesis that migrate predominantly into tumor tissue. However, property MSCs is not clear demonstrated and requires further experimental confirmation. aim our study identify how growth affects distribution after systemic administration a...
Разработаны оптимальные условия для приготовления питательной среды бессывороточной ВекторВак-ПС2 сухой стерильной. Это позволит получать высококачественные результаты при культивировании клеток MDCK и Vero удешевит стоимость в отличие от жидкой. Разработка такой стерильной является одной из важнейших задач биотехнологии, поскольку имеет ряд преимуществ: жидкая питательная среда требует специального хранения транспортировки, а сухая представляет собой порошок, который очень легко хранить...
Разработаны оптимальные условия для приготовления сухих стерильных питательных сред (питательная среда Игла МЕМ сухая стерильная, питательная DMEM 199 модифицированная стерильная) и из них жидкой формы. Это позволит получать высококачественные результаты при выращивании культур клеток в лаборатории, а также удешевит стоимость сред. Сухие стерильные питательные среды прошли все контроли показали хорошие ростовой активности на клеточных культурах Vero, L-68 Нер-2, что свидетельствует о...
Оптимальной и стандартизованной является наработка вирусной биомассы на перевиваемых культурах клеток. Клетки, используемые в качестве субстрата, основе которых производится вакцина, должны быть аттестованы. В ФБУН ГНЦ ВБ «Вектор» Роспотребнадзора созданы главный рабочий банк культуры клеток Vero (E-6). Культура составе этих банков имеет высокую пролиферативную активность, типичную для данной линии морфологию характерные африканской зеленой мартышки (C. aethiops) кариотип энзимограмму. не...