A5107974312- Virology and Viral Diseases
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Neuroscience and Neuropharmacology Research
- Plant Virus Research Studies
- Viral Infections and Outbreaks Research
- Animal Nutrition and Physiology
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Vaccine Coverage and Hesitancy
- Hepatitis C virus research
- Immune Response and Inflammation
- Microbial infections and disease research
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Viral-associated cancers and disorders
- interferon and immune responses
- Hepatitis B Virus Studies
Lancaster University
2018-2025
National Institute of Health
2023
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
Pakistan Health Research Council
2013-2018
The Pirbright Institute
2014-2018
Furness College
2018
Social Action
2016
Institut Agronomique et Vétérinaire Hassan II
2014
National Institute of Animal Biotechnology
2014
Several Avian paramyxoviruses 1 (synonymous with Newcastle disease virus or NDV, used hereafter) classification systems have been proposed for strain identification and differentiation. These pioneered efforts; however, they were based on different approaches lacked objective criteria the differentiation of isolates. differences created discrepancies among systems, rendering discussions comparisons across studies difficult. Although a system that was by Diel co-workers in 2012, ample...
Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, Middle East, Africa. We used complete partial genome sequences all 4 lineages to investigate evolutionary epidemiologic dynamics PPRV. A Bayesian phylogenetic analysis PPRV mapped time most recent common ancestor initial divergence lineage III isolate at beginning 20th...
Global deployment of an effective and safe vaccine is necessary to curtail the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Here, we evaluated a Newcastle virus (NDV)-based vectored-vaccine in mice hamsters for its immunogenicity, safety, protective efficacy against SARS-CoV-2. Intranasal administration recombinant (r)NDV-S expressing spike (S) protein SARS-CoV-2 induced high levels SARS-CoV-2-specific neutralizing immunoglobulin A (IgA)...
Abstract Oncolytic viruses (OVs) can selectively infect and lyse cancer cells while simultaneously activating the host immune system making them a prospective class of anticancer immunotherapeutic agents. In particular, mammalian reovirus (MRV) avian (ARV) have gained unique attention for their significant properties clinical potentials. This review explores mechanisms action, immunological interactions, applications in OV therapy. Studies shown that MRV exploits defective antiviral...
The Global Adult Tobacco Survey (GATS) is the global standard for systematically monitoring adult tobacco use and tracking key control indicators. Using a multistage stratified cluster design, 9856 households were sampled, one individual was randomly selected from each household. Standard GATS questionnaire used to collect information on use, cessation, second-hand smoke, knowledge, attitudes, perceptions. Data analyzed per protocol. Of individuals, 7831 individuals completed interview....
Abstract The intracellular actions of interferon (IFN)-regulated proteins, including IFN-induced proteins with tetratricopeptide repeats (IFITs), attribute a major component the protective antiviral host defense. Here we applied genomics approaches to annotate chicken IFIT locus and currently identified single (chIFIT5) gene. profound transcriptional level this effector innate immunity was mapped within its unique cis-acting elements. This highly virus- IFN-responsive chIFIT5 protein...
Hepatitis B and C are chronic diseases with mental social impacts which can result in poor quality of life.The aim this study was to determine the experiences stigma a sample hepatitis B-and C-positive patients Pakistan.In cross-sectional study, 140 inpatients outpatients from 3 tertiary-care hospitals Islamabad Rawalpindi answered semi-structured questionnaire about experienced relatives, friends, spouse health-care providers, work/financial problems.The majority (75%) said they had change...
Newcastle disease virus (NDV) causes a highly devastating and contagious in poultry, which is mainly attributed to extensive tissue damages the digestive, respiratory nervous systems. However, nature dynamics of NDV-induced oxidative stresses intestine chickens remain elusive.In this study, we examined magnitude intestinal stress histopathological changes caused by virulent NDV infection, explored protective roles vitamin E (vit. E) ameliorating these pathological changes. For purposes, were...
Purpose This study aims to investigate the impact of dividend policy on a firm’s participation in corporate social responsibility (CSR)-related activities context Pakistani firms. Furthermore, role board governance mechanism policy-CSR is investigated. Design/methodology/approach The study’s sample consists 115 nonfinancial Pakistan Stock Exchange-listed firms from 2010 2021. A multidimensional financial method used assess CSR engagement, and assessed using payout ratio yield. authors fixed...
Isolates of peste des petits ruminants virus (PPRV) can be segregated genetically into four lineages. For decades, lineages I-III have been reported across Africa whilst lineage IV has predominantly circulated Asia. However, the distribution is currently changing in Africa. Importantly, full genome sequence data for African field isolates lacking. Here, we announce first complete a isolate from East This was derived intestine goat suffering severe clinical disease during 2010 outbreak...
Antibiotics are commonly used as the first line of defense in treatment infectious diseases. However, rise antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic strategies urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for “on-demand” activation acetyl donor molecules. The process generates an aqueous-based formulation comprising rich mixture highly oxidizing molecules: peracetic acid, hydrogen...
Newcastle disease (ND), caused by ND virus (NDV), is one of the most infectious and economically important diseases poultry industry worldwide. While infections are reported in a wide range avian species, pathogenicity chicken-origin virulent NDV isolates ducks remains elusive. In this study, two strains were isolated biologically genetically characterized from an outbreak chickens apparently healthy ducks. Pathogenicity assessment indices, including mean death time (MDT), intracerebral...
Newcastle disease (ND), characterized by visceral, respiratory, and neurological pathologies, causes heavy economic loss in the poultry industry around globe. While significant advances have been made effective diagnosis vaccine development, molecular mechanisms of ND virus (NDV)-induced neuropathologies remain elusive. In this study, we report magnitude oxidative stress histopathological changes induced virulent NDV (ZJ1 strain) assess impact vitamin E alleviating these pathologies....
Fecal excretion of Cryptosporidium parvum oocysts was determined in 625 children less than five years old who presented at the pediatric clinic a teaching hospital Rawalpindi, Pakistan. Single stool specimens were collected from 475 with acute diarrhea and 150 without diarrhea. The infection rate significantly higher (10.3% versus 3.3%). C. highest 19-24 months age (21.8%). There no significant difference among male female any group studied. Sociodemographic information, drinking water...
To determine the asymptomatic dengue infection in adults of Pakistani population.This study was conducted five major cities (Islamabad, Karachi, Lahore, Multan, and Peshawar) Pakistan. A total 5 230 aged 18 years above without a history fever at any point their life were enrolled from participating laboratories. Those who confirmed for previously excluded. Of total, 62.6% (n = 3 276) male with an average age 34.6 years. Participants briefed about objectives study, written consent obtained to...
Abstract A string of complete genome sequences Small ruminant morbillivirus (SRMV) have been reported from different parts the globe including Asia, Africa and Middle East. Despite individual sequence-based analysis, there is a paucity comparative genomic evolutionary analysis to provide overarching comprehensive insights. Therefore, we first enriched existing database SRMVs with Pakistan-originated strains then explored overall nucleotide diversity, residue characteristics, deduced an...