A5011642337- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- CAR-T cell therapy research
- Virus-based gene therapy research
- Salmonella and Campylobacter epidemiology
- T-cell and Retrovirus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Virology and Viral Diseases
- Plant Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Vector-Borne Animal Diseases
- Hepatitis C virus research
Technical University of Munich
2024
Zagazig University
2015-2022
Helmholtz Zentrum München
2015
The hepatitis B virus (HBV) particle is an icosahedral nucleocapsid surrounded by a lipid envelope containing viral surface proteins. A small domain (matrix [MD]) in the large protein L and narrow region binding [MBD]) including isoleucine 126 on capsid have been mapped, which point mutations such as core I126A specifically blocked envelopment. It possible that two domains interact with each other during virion morphogenesis. By systematic evolution of ligands exponential enrichment (SELEX)...
During hepatitis B virus (HBV) infections, subviral particles (SVP) consisting only of viral envelope proteins and lipids are secreted. Heterologous expression the small protein S in mammalian cells is sufficient for SVP generation. synthesized as a transmembrane with N-terminal (TM1), central (TM2), hydrophobic C-terminal (HCR) domains. The loops between TM1 TM2 (the cytosolic loop [CL]) HCR luminal [LL]) located cytosol endoplasmic reticulum (ER) lumen, respectively. To define domains...
The control of Newcastle disease virus (NDV) infection depends solely on vaccination which in most cases is not sufficient to restrain the consequences such a highly evolving viral disease. Finding out substances for preparing an efficient anti-ND drug would be high value. n-Docosanol saturated fatty alcohol with inhibitory effect against many enveloped viruses. In this study, we evaluated therapeutic n-docosanol NDV and shedding chickens. Chickens infected virulent were treated low...
Bovine viral diarrhea virus (BVDV) exists in two main biotypes: cytopathic (cp) and noncytopathic (ncp). Although some studies were done on the effect of interferon alpha (IFN-α) BVDV, exogenous IFN against BVDV biotypes remains unclear. In present study, we evaluated comparative human IFN-α (HuIFN-α) different genotypes. The results showed that HuIFN-α greatly inhibited growth However, HuINF-α has a significant inhibitory cp biotype compared to ncp one without variation between reached...
<title>Abstract</title> <bold>Background:</bold> Human adenoviruses (HAdVs) frequently cause common respiratory or gastrointestinal infections among children, adults, individuals with immune deficiencies and other vulnerable populations varying degree of symptoms, ranging from mild to server, in some cases, even fatalities. Despite the significant clinical impact HAdVs, there is currently no approved vaccine available. <bold>Methods:</bold> This study explores potential adenovirus type 5...
Abstract Background Human adenoviruses (HAdVs) frequently cause common respiratory or gastrointestinal infections among children, adults, individuals with immune deficiencies, and other vulnerable populations varying degree of symptoms, ranging from mild to server, in some cases, even fatalities. Despite the significant clinical impact HAdVs, there is currently no approved vaccine available. Methods This study explores potential adenovirus type 5 fiber knob (Ad5-FK) stimulate production...
Foot-and-mouth disease (FMD) is endemic in Egypt and most parts of Africa causing huge economic losses. Control FMD using vaccination requires information on the occurrence various FMDV serotypes. This study aimed to determine prevalence serotypes Sharkia Governorate, Egypt. A total number 643 different samples, within ten localities, were collected from both cattle buffaloes (n = 283) different, age, sex, immune status against FMD, health status. Field samples 360) have been screened for by...