A5040402806- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
University of Southampton
2022
Electro-reductive radical cyclisation of aryl halides affords the corresponding hetero- and carbo-cycles in an undivided flow reactor equipped with steel carbon electrodes using organic mediator. A dissolving metal anode is not needed, mediator can be employed a sub-stoichiometric amount (0.05 equiv), increasing practical utility cathodic cyclisation. The methodology applied to O-, N-, C-tethers, yielding tricyclic fused spiro systems. In absence mediator, major pathway hydrogenolysis C-X bond, 2 e
Abstract Electro‐reductive radical cyclisation of aryl halides affords the corresponding hetero‐ and carbo‐cycles in an undivided flow reactor equipped with steel carbon electrodes using organic mediator. A dissolving metal anode is not needed, mediator can be employed a sub‐stoichiometric amount (0.05 equiv), increasing practical utility cathodic cyclisation. The methodology applied to O‐, N‐, C‐tethers, yielding tricyclic fused spiro systems. In absence mediator, major pathway...