A5007221495- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Catalytic Alkyne Reactions
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Organic Chemistry Cycloaddition Reactions
- Cyclopropane Reaction Mechanisms
- Advanced Synthetic Organic Chemistry
- Alkaloids: synthesis and pharmacology
- Microbial Natural Products and Biosynthesis
- Synthesis and Catalytic Reactions
- Marine Sponges and Natural Products
- Coordination Chemistry and Organometallics
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Cancer Treatment and Pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Crystallography and molecular interactions
Imperial College London
2016-2025
Molecular Sciences Institute
2018-2022
Transnational Press London
2020
Columbia University
2017
Velindre Cancer Centre
2017
University of Sussex
2001-2011
Novartis (Switzerland)
2007
Novartis Institutes for BioMedical Research
2007
GlaxoSmithKline (United Kingdom)
2007
Pfizer (United Kingdom)
2007
Electro-reductive radical cyclisation of aryl halides affords the corresponding hetero- and carbo-cycles in an undivided flow reactor equipped with steel carbon electrodes using organic mediator. A dissolving metal anode is not needed, mediator can be employed a sub-stoichiometric amount (0.05 equiv), increasing practical utility cathodic cyclisation. The methodology applied to O-, N-, C-tethers, yielding tricyclic fused spiro systems. In absence mediator, major pathway hydrogenolysis C-X bond, 2 e
Medical Journal of AustraliaVolume 1, Issue 9 p. 249-261 Original Article NON-SUPPURATIVE HEPATITIS: A STUDY OF ACUTE AND CHRONIC FORMS WITH SPECIAL REFERENCE TO BIOCHEMICAL HISTOLOGICAL CHANGES I. J. Wood, Wood Clinical Research Unit, Walter and Eliza Hall Institute the Royal Melbourne HospitalAided by a grant from National Health Council.Search for more papers this authorW. E. King, W. King authorP. Parsons, P. Parsons HospitalWyeth Fellow in Medicine.Search authorJ. Perrt, Perrt authorM....
Highly encumbered 2,2',6-tri- and 2,2',6,6'-tetra-substituted biaryls are readily prepared from aryl ortho-iodobenzyl ethers through mediated cathodic reduction under flow. The reaction proceeds via the stepwise transfer of two electrons: first to induce loss iodide a radical cyclisation, second polar fragmentation.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-catalyzed polycyclization of dienynes: surprisingly facile formation tetracyclic systems containing a three-membered ringFrank E. Meyer, Philip J. Parsons, and Armin De MeijereCite this: Org. Chem. 1991, 56, 23, 6487–6488Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/jo00023a003https://doi.org/10.1021/jo00023a003research-articleACS...
A resonant pressure sensor has been fabricated which consists of a single-crystal silicon beam located in the center diaphragm. The is excited electrostatically and its motion are detected by piezoresistors. structure with fusion bonding. Overall measurement accuracies 0.01% have achieved. This designed to meet exacting standards required for aerospace air data computers engine control applications where achievable 0.1% absolute required. principle operation imply measure change frequency...
A method for the construction of pyrrolizidine rings is described using a new radical cyclisation procedure, which involves generation an allylic from preformed vinylic followed by onto pendant double bond.
Abstract The transition-metal-free total syntheses of the oxygenated carbazole natural products glycoborine, carbazomycin A and B are reported. key step involves an NBS-mediated cyclobutanol ring expansion to 4-tetralones for preparation tricyclic core.
Remarkable increases of molecular complexity in a single procedural step are achieved with the title reaction. Only slight modification substitution pattern on acyclic precursor 2 can change mode tetracyclization to either yield skeletons type 1 or 3 exclusively.
While the prop-2-ynyl acetates (1) rearrange to allenyl (2) in boiling benzene containing copper(I) chloride, presence of silver trifluoroacetate butadienyl (3), useful Diels–Alder reactions, are formed high yield.
1-Phenylthiovinyl-lithium adds to n-hexanal give the allylic alcohol (II) that undergoes Carroll and Claisen rearrangement with formation of carbonyl compounds (IV) which can be converted into dihydrojasmone (VIa) 2-n-pentylcyclopent-2-enone (VIb) by hydrolysis cyclisation.
(+)-Hongoquercin A and B were synthesized from commercially available trans,trans-farnesol in six eleven steps, respectively, using dual biomimetic strategies with polyketide aromatization subsequent polyene functionalization a common farnesyl-resorcylate intermediate. Key steps involve Pd(0)-catalyzed decarboxylative allylic rearrangement of dioxinone β,δ-diketo ester to dioxinone, which was readily aromatized into the corresponding resorcylate, cyclization via enantioselective protonation...
Various 2-bromododeca-1,11-dien-6-ynes 1a,b,8 and trans- or cis-10a,b when subjected to Heck reaction conditions, cleanly undergo palladium-catalysed biscyclizations followed by an electrocyclic rearrangement form tricyclic cyclohexadienes 5a,b, 9 cis- trans-11a,b as sole products (7 examples).
Trapping of the ketene generated from thermolysis 2-methyl-2-phenyl-1,3-dioxane-4,6-dione-keto-dioxinone at 50 °C with primary, secondary, or tertiary alcohols gave corresponding dioxinone β-keto-esters in good yield under neutral conditions. These intermediates were converted by palladium(0)-catalyzed decarboxylative allyl migration and aromatization into β-resorcylates. transformations applied to syntheses natural products (±)-cannabiorcichromenic (±)-daurichromenic acid.
A facile and transition-metal-free ring expansion of the cyclobutanol moiety to 4-tetralones fused heteroaromatic systems is described. The oxidative proceeds rapidly regioselectively through mediation by N-bromosuccinimide acetonitrile in satisfactory good yields. preparation precursors have proven be scalable are straightforward carry out.
The first total synthesis of five austalide natural products, (±)-17S-dihydroaustalide K, (±)-austalide (±)-13-deacetoxyaustalide I, P, and (±)-13-deoxyaustalide Q acid, was accomplished via a series biomimetic transformations. Key steps involved polyketide aromatization trans,trans-farnesol-derived β,δ-diketodioxinone into the corresponding β-resorcylate, followed by titanium(III)-mediated reductive radical cyclization an epoxide to furnish drimene core. Subsequent phenylselenonium ion...
Advances in the transition-metal-free cyclobutanol ring expansion to 4-tetralones under N-bromosuccinimide mediation are described. We have expanded scope of this methodology and investigated effect substituents on aromatic ring, moiety, outcome reaction. Limitations with certain moiety also Further experimental evidence support our mechanistic understanding is disclosed, we now preclude suggested involvement a primary radical for transformation.