A5059851183- Developmental Biology and Gene Regulation
- Congenital Anomalies and Fetal Surgery
- Neurogenesis and neuroplasticity mechanisms
- Congenital gastrointestinal and neural anomalies
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Genomics and Chromatin Dynamics
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Neuroendocrine Tumor Research Advances
- Cell Image Analysis Techniques
- Hippo pathway signaling and YAP/TAZ
- Spinal Cord Injury Research
- Genital Health and Disease
- Parvovirus B19 Infection Studies
- PI3K/AKT/mTOR signaling in cancer
- Tumors and Oncological Cases
- Nuclear Receptors and Signaling
University of Pennsylvania Health System
2018-2022
Hospital of the University of Pennsylvania
2018-2022
Pennsylvania Hospital
2018-2022
California University of Pennsylvania
2022
Johnson University
2008-2017
Rutgers, The State University of New Jersey
2006-2017
Polycomb bodies are foci of proteins in which different target genes thought to co-localize the nucleus, looping out from their chromosomal context. We have shown previously that insulators, not response elements (PREs), mediate associations among Group (PcG) targets form bodies. Here we use live imaging and 3C interactions show transgenes containing PREs endogenous PcG-regulated targeted by insulator nuclear structures depending on state activity. When two repressed, they both active,...
Chromatin environments differ greatly within a eukaryotic genome, depending on expression state, chromosomal location, and nuclear position. In genomic regions characterized by high repeat content gene density, chromatin structure must silence transposable elements but permit of embedded genes. We have investigated one such region, chromosome 4 Drosophila melanogaster. Using chromatin-immunoprecipitation followed microarray (ChIP–chip) analysis, we examined enrichment patterns 20 histone...
Abstract Proper central nervous system (CNS) function depends critically on the generation of functionally distinct neuronal types in specific and reproducible positions. The diversity during CNS development involves a fine balance between dividing neural progenitors differentiated progeny that they produce. However, molecular mechanisms regulate these processes are still poorly understood. Here, we show Prox1 transcription factor, which is expressed transiently specifically spinal...
Primary pulmonary myxoid sarcoma (PPMS) is a recently reported, exceedingly rare low-grade lung neoplasm characterized by reticular/lace-like growth of spindle to epithelioid cells embedded in an abundant matrix. Morphologically, it overlaps with variant angiomatoid fibrous histiocytoma (AFH) the soft tissue. Genetically, they were both reported harbor EWSR1-CREB1 fusion, while EWSR1-ATF1 has only been AFH thus far. We report case primary cell tumor morphologic and immunohistochemical...
Sindbis virus (SV) is the prototype of alphaviruses which are a group widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 an RNA-binding protein that shuttles between nucleus cytoplasm. Our recent studies found hnRNP relocates from to cytoplasm in (SV)-infected cells. binds 5' UTR SV RNA facilitates viral replication translation.Making use standard molecular techniques, virology methods vitro system developed by our lab assess role positive...
Background: Functional constipation (FC) is a common gastrointestinal (GI) disorder characterized by symptoms of without clear physiologic or anatomic cause. Gut microbiome dysbiosis has been postulated to be factor in the development FC, and treatment with probiotic regimens, including strains Lactobacillus plantarum (L. plantarum), demonstrated efficacy managing symptoms. To further understand role L. GI health, we conducted an animal study randomized, double-blind, placebo-controlled...
The Notch signaling pathway controls cell fate decision, proliferation, and other biological functions in both vertebrates invertebrates. Precise regulation of the canonical ensures robustness signal throughout development adult tissue homeostasis. Aberrant results profound developmental defects is linked to many human diseases. In this study, we identified Atrophin family protein RERE (also called Atro2) as a positive regulator target Hes genes developing vertebrate spinal cord. Prior...
Objective: This study investigated the correlation between choline/creatine (Cho/Cr) ratios determined by multivoxel proton magnetic resonance spectroscopy ( 1 H-MRS) and distribution of cancer stem-like cells (CSLCs) in high-grade gliomas. Patients methods: Sixteen patients with gliomas were recruited underwent H-MRS examination before surgery to identify distinct tumor regions variable Cho/Cr ratios. Using intraoperative neuronavigation, tissues accurately sampled from high low within each...
The original article to which this Erratum refers was published in Developmental Dynamics 237:393–402. In the version of a typographical error introduced, incorrectly spelling Dr. Misra's surname. Please find correct her name given here. Publisher regrets error.
In the original published version of article, “Prox1 regulates a transitory state for interneuron neurogenesis in spinal cord,” figure legend Figure 1 included errors that incorrectly labeled images. To clarify, authors have provided following correction to 1: Figures 1A-C are from chick, and D-K M E10.5 mouse. The regret this error.
Extragonadal yolk sac tumor (YST) is a rare malignant neoplasm that usually arises in mediastinal, sacrococcygeal, retroperitoneal and head neck regions. Only seven cases of primary prostatic YST have been reported the literature. We report case young adult. A 26-year-old man was admitted with history urinary urgency, hematuria, hematochezia, pelvic pain. Abdominal CT/MRI scans showed 12.0 x 11.0 9.1 cm mass locally invading rectum bladder lymphadenopathy hepatic metastases. No testicular...
Pancreatic ductal adenocarcinoma is a very aggressive neoplasm with low survival rate, comprising the majority of pancreatic malignancies. Psammoma bodies have rarely been reported in adenocarcinoma, and their clinicopathologic significance unclear. In this report we will discuss case slow-growing arising neck/body coincidental neuroendocrine tumor tail. Prominent psammoma are observed carcinoma (absent tumor). The presence within an indolent unusual suggests possible association favorable...