A5037771619- Micro and Nano Robotics
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Molecular Communication and Nanonetworks
- Cellular Mechanics and Interactions
- Protist diversity and phylogeny
- Polymer Surface Interaction Studies
- Pickering emulsions and particle stabilization
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Modular Robots and Swarm Intelligence
- Advanced Materials and Mechanics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Renal and related cancers
- Gold and Silver Nanoparticles Synthesis and Applications
- Virus-based gene therapy research
- Complement system in diseases
- Cancer Genomics and Diagnostics
- Silk-based biomaterials and applications
- Surface Modification and Superhydrophobicity
- Advanced Surface Polishing Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Tryptophan and brain disorders
- Bacterial biofilms and quorum sensing
- Electrohydrodynamics and Fluid Dynamics
System Biosciences (United States)
2020
Max Planck Institute for Intelligent Systems
2015-2017
Stuttgart Observatory
2015
Worcester Polytechnic Institute
2011-2014
Rensselaer Polytechnic Institute
1987
Self-propelled colloids have emerged as a new class of active matter over the past decade. These are micrometer sized colloidal objects that transduce free energy from their surroundings and convert it to directed motion. The self-propelled in many ways, synthetic analogues biological units such algae or bacteria. Although they propelled by very different mechanisms, swimmers typically powered flagellar motion driven local chemical reactions, share number common features with respect...
This article focuses on bioprinting utilizing hydrogels as 3D scaffolds.
Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these includes the use nanoparticles as carriers delivery, where they randomly circulate in fluid until make contact with infected areas. However, required proximity particles biofilm results only moderate efficacy. We demonstrate here that nonpathogenic magnetotactic bacteria Magnetosopirrillum gryphiswalense (MSR-1) can be integrated drug-loaded mesoporous silica...
Bacteria biohybrids employ the motility and power of swimming bacteria to carry maneuver microscale particles. They have potential perform microdrug cargo delivery in vivo, but been limited by poor design, reduced capabilities, impeded functionality. To address these challenge, motile Escherichia coli are captured inside electropolymerized microtubes, exhibiting first report a microswimmer that does not utilize spherical particle chassis. Single bacterium becomes partially trapped within...
Water contamination is one of the most persistent problems public health. Resistance some pathogens to conventional disinfectants can require combination multiple or increased disinfectant doses, which may produce harmful byproducts. Here, we describe an efficient method for disinfecting Escherichia coli and removing bacteria from contaminated water using self-propelled Janus microbots decorated with silver nanoparticles (AgNPs). The structure a spherical microbot consists magnesium (Mg)...
There has been a significant interest in the development of microswimmers for medical drug and cargo delivery, but majority current micromotors rely on toxic fuel sources materials their design making them irrelevant biomedical applications. Bacteria represent an excellent motor alternative, as they are powered using surrounding biological fluids. For motile, biohybrid swimmer, Escherichia coli ( E. ) integrated onto metal capped, polystyrene (PS) Janus particles. Fabrication is rapid simple...
This article will focus on recent reports that have applied 3D printing for designing millimeter to micrometer architecture robotic motility.
Self-propelled micromotors are emerging as important tools that help us understand the fundamentals of motion at microscale and nanoscale. Development motors for various biomedical environmental applications is being pursued. Multiple fabrication methods can be used to construct geometries different sizes motors. Here, we present an overview appropriate according both size shape requirements concept guiding catalytic within confines wall. Micromotors have also been incorporated with...
Summary Stem cells are unique cell populations able to copy themselves exactly as well specialize into new types. isolated from early stages of embryo development pluripotent, i.e., can be differentiated multiple different In addition, scientists have found a way reverting specialized an adult embryonic-like state. These cells, that effective embryos, termed induced pluripotent stem (iPSCs). The potency iPSC technology is recently being employed by researchers aimed at helping wildlife and...
Abstract In the field of micromotors many efforts have been taken to find a substitute for peroxide as fuel. While most approaches turn towards other toxic high energy chemicals such hydrazine, we introduce here an source that is widely used in nature: light. Light ideal and some materials, AgCl, inherent property transform light chemical processes, which can be achieve propulsion. case silver chloride, one process observed after exposure surface modification, leads release ions, generating...
Designing complex tissue culture systems requires cell alignment and directed extracellular matrix (ECM) gene expression. Here, a micro‐rough, polydimethylsiloxane (PDMS) surface, that also integrates micro‐pattern of 50 µm wide lines fibronectin (FN) separated by 60 bovine serum albumin (BSA), is developed. Human fibroblasts cultured on the rough, patterned substrate have aligned growth significant change in morphology when compared to cells flat, surface. The rough PDMS topography...
The immediate physical and chemical surroundings of cells provide important biochemical cues for their behavior. Designing tailoring biomaterials controlled cell signaling extracellular matrix (ECM) can be difficult due to the complexity cell-surface relationship. To address this issue, our research has led development a polydimethylsiloxane (PDMS) scaffold with defined microtopography chemistry surface driven ECM assembly. When human fibroblasts were cultured on microtextured PDMS 2-6 µm...
Abstract Cerebral organoids provide unparalleled access to human brain development in vitro. However, variability induced by current culture methodologies precludes using as robust disease models. To address this, we developed an automated Organoid Culture and Assay (ORCA) system support longitudinal unbiased phenotyping of at scale across multiple patient lines. We then characterized organoid novel machine learning methods found that the contribution donor, clone, batch is significant...
Abstract Human-derived cortical organoids (hCOs) recapitulate cell diversity and 3D structure found in the human brain offer a promising model for discovery of new gene therapies targeting neurological disorders. Adeno-associated viruses (AAVs) are most vehicles non-invasive delivery to central nervous system (CNS), but reliable reproducible vitro models assess their clinical potential lacking. hCOs can take on these issues as they physiologically relevant AAV transduction efficiency,...
In article number 1500505, S. Sánchez and co-workers describe the fabrication of motile biohybrid swimmers. Escherichia coli adhere to metal caps on polystyrene (PS) Janus particles. The regulated cell adhesion allows PS surface be utilized for drug attachment, creating a multifunctional system. E. demonstrate ability carry multiple cargo loads, while maintaining high viability proliferation.
Abstract Elevated expression of the complement component 4A (C4A) protein has been linked to an increased risk schizophrenia (SCZ). However, there are few human models available study mechanisms by which C4A contributes development SCZ. In this study, we established a overexpressing neuroimmune cortical organoid (NICO) model, includes mature neuronal cells, astrocytes, and functional microglia. The NICO model recapitulated several endophenotypes observed in SCZ patients, including modulation...
The recent resurgence of interest in Wafer Scale Integration (WSI) is driven by a requirement for dense multilayer interconnect at wiring capacities far excess that which achievable ceramic hybrid packages. All the problems associated with achieving satisfactory yield such structures must now be reexamined to see whether current technology capable what has proven so elusive past. One relevant technologies direct write electron beam lithography. Initially. efforts are being directed...