A5074808820- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eicosanoids and Hypertension Pharmacology
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
University of Zurich
2023-2024
Abstract Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation low is regulated by oxygen‐sensitive transcription factors, the hypoxia‐inducible factors (HIFs). function of HIFs for NK cell activation and metabolic rewiring remains controversial. Activated predominantly glycolytic, but programs that ensure maintenance enigmatic. By combining in situ metabolomic transcriptomic analyses murine cells, our study defines...
Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries aldosterone-producing zona glomerulosa. We demonstrate that preserve capillary specialization modulate aldosterone secretion. Using macrophage-specific deletion of VEGF-A, single-cell transcriptomics, functional phenotyping, we found loss VEGF-A depletes PLVAP+ fenestrated endothelial cells glomerulosa, leading to increased basement...
Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation oxygen mediated hypoxia-inducible transcription factors (HIFs), HIF-1α subunit shapes an ILC phenotype upon acute colitis that contributes damage. However, impact of HIF signaling in NKp46 + ILCs context repetitive mucosal damage chronic inflammation, as it typically occurs during inflammatory bowel disease, unknown. In colitis,...