A5041758302- Hormonal Regulation and Hypertension
- Signaling Pathways in Disease
- Ion Transport and Channel Regulation
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Metallurgy and Cultural Artifacts
- Russia and Soviet political economy
- Bone Tumor Diagnosis and Treatments
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- Ion Channels and Receptors
- Electrolyte and hormonal disorders
- Global Energy Security and Policy
- Macrophage Migration Inhibitory Factor
- Glioma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Bone health and treatments
- Kawasaki Disease and Coronary Complications
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
Harvard University
2024
Boston Children's Hospital
2024
Boston Children's Museum
2024
University of Zurich
2020-2024
Boğaziçi University
2017
Royal Adelaide Hospital
1982
Inflammasomes are multiprotein complexes that sense pathogen-associated and danger-associated molecular patterns induce inflammation in cells. The NALP3 inflammasome is tightly regulated by recently discovered control mechanisms, but other modulators still remain to be characterized. NLR family CARD-containing 3 (NLRC3) protein, a caspase recruitment domain (CARD)-containing member of the nucleotide oligomerization domain-like receptor (NLR) family, was found down-regulate NF-κB pathway...
Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries aldosterone-producing zona glomerulosa. We demonstrate that preserve capillary specialization modulate aldosterone secretion. Using macrophage-specific deletion of VEGF-A, single-cell transcriptomics, functional phenotyping, we found loss VEGF-A depletes PLVAP+ fenestrated endothelial cells glomerulosa, leading to increased basement...
The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low plasma aldosterone levels despite concomitant hyperkalemia hyperreninemia. We tested hypothesis that Cn participates signal transduction pathway regulating synthesis. Inhibition with tacrolimus abolished potassium-stimulated (K+-stimulated)...
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of adrenal gland, is a master regulator plasma electrolytes and blood pressure. While aldosterone control renin-angiotensin system well understood, other key regulatory factors have remained elusive. Here, we replicated prior association between non-coding variant in
Abstract Disclosure: K.S. Borges: None. D.W. Little III: T. de Almeida Magalhães: C. Ribeiro: K. Basham: Dumonte: S. Azova: A.E. O’Connell: N.A. Guagliardo: P.Q. Barrett: M. Berber: D. Mohan: A. Turcu: W. Rainey: A.M. Lerario: D.L. Carlone: Salic: D.T. Breault: G.D. Hammer: The steroid hormone aldosterone, produced by the zona glomerulosa (ZG) of adrenal gland, plays a key role in regulating plasma electrolyte levels and blood pressure. ZG dysregulation, major driver primary aldosteronism...
Abstract Disclosure: V. Chortis: None. C. Yao: Ribeiro: L. Kelley: Nagano: M. Berber: S. Raveenthiraraj: P. Vendramini: K. Kiseljak-Vassiliades: D.L. Carlone: M.C. Haigis: K.S. Borges: D.T. Breault: Dysregulation of cellular metabolism is a hallmark feature cancer that can be targeted therapeutically but remains underexplored in adrenocortical carcinoma (ACC), despite the urgent need for improved treatments. We employed recently developed transgenic mouse model ACC (BPCre), driven by two...
Abstract Disclosure: M. Berber: None. N.A. Guagliardo: P.Q. Barrett: B. Haykir: V. Chortis: K.S. Borges: D.L. Carlone: D.T. Breault: Primary aldosteronism (PA) caused by the autonomous production of aldosterone zona Glomerulosa (zG) cells adrenal gland is most common cause endocrine hypertension, which increases risk cardiovascular and renal disease, independent blood pressure. Current treatments with mineralocorticoid receptor antagonists do not fully mitigate these risks. Thus, a better...
The mineralocorticoid aldosterone promotes renal K+ excretion and Na+ reabsorption; thereby it is critical for the regulation of ion homeostasis blood pressure. Interestingly, immunosuppression therapy with protein phosphatase 3 (calcineurin) inhibitors often results in rather low plasma levels despite a concomitant hyperkalemia hyperreninemia. Calcineurin (Cn) calcium calmodulin-dependent expressed adrenal cortex. We tested hypothesis that Cn participates signal transduction pathway...
Abstract The mineralocorticoid aldosterone secreted by the adrenal zona glomerulosa (ZG) cells promote renal K+ secretion and Na+ reabsorption; thereby it is critical for control of ion homeostasis blood pressure. While Ca2+/calmodulin-dependent protein kinase (CAMK) pathway regulating stimulated production well studied, little known about potentially involved phosphatases. Interestingly, immunosuppression therapy transplanted patients with phosphatase 3 (calcineurin) inhibitors often...
Abstract Background: Hypercalcemia is a commonly encountered paraneoplastic manifestation of certain cancers with or without endocrine differentiation. However, the association between adrenocortical carcinoma (ACC) hypercalcemia very rare, and therefore little known about cause its relevance in disease. Clinical Case: A 40-year-old woman presented hospital 5-month history progressive flank pain unintentional weight loss 6 kg. MRI revealed mass 9x8.1x4.8 cm right adrenal gland inhomogeneous...