A5076580010- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- CO2 Reduction Techniques and Catalysts
- biodegradable polymer synthesis and properties
- Gene expression and cancer classification
- Carbon dioxide utilization in catalysis
- Molecular Biology Techniques and Applications
- Catalytic Processes in Materials Science
- Ionic liquids properties and applications
- Advanced Proteomics Techniques and Applications
- Advanced Chemical Physics Studies
- Lanthanide and Transition Metal Complexes
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Catalysis and Oxidation Reactions
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Radioactive element chemistry and processing
- Metal-Catalyzed Oxygenation Mechanisms
- Glycosylation and Glycoproteins Research
Texas A&M University
2018-2021
The practical application of new single molecule protein sequencing (SMPS) technologies requires accurate estimates their associated error rates. Here, we describe the development and two distinct parameter estimation methods for analyzing SMPS reads produced by fluorosequencing. A Hidden Markov Model (HMM) based approach, extends whatprot, where previously used HMMs peptide-read matching. This extension offers a principled approach estimating key parameters fluorosequencing experiments,...
The copolymerization of CO2 and epoxides in the presence chain-transfer agents (CTAs) has provided a well-controlled route to polycarbonate polyols. Upon employing dicarboxylic acid CTAs which contain discrete metal-binding sites, it is possible synthesize polycarbonates with single-metal complex present main chain, either during process or postpolymerization procedure. In these ways, (bipy)Re(CO)3Br been incorporated into backbone. Furthermore, one-pot, two-step synthesis, second epoxide...
We have designed and synthesized poly(monothiocarbonate)s containing a single well-defined metal complex in the polymers' backbone via immortal copolymerization of carbonyl sulfide propylene oxide presence chain transfer agents (CTAs). Our initial studies this area involved utilization diols, which serve as CTAs. Included investigation are complexes ()Cr(CO)3 ()Re(CO)3Br. Because electron-withdrawing abilities fragments, CTA afforded catalyst-alkoxide bonds not sufficiently nucleophilic to...
ABSTRACT The need to accurately survey proteins and their modifications with ever higher sensitivities, particularly in clinical settings limited samples, is spurring development of new single molecule proteomics technologies. Fluorosequencing one such highly parallelized peptide sequencing platform, based on determining the sequence positions select amino acid types within peptides enable identification quantification from a reference database. Here, we describe substantial improvements...
The practical application of new single molecule protein sequencing (SMPS) technologies requires accurate estimates their associated error rates. Here, we describe the development and two distinct parameter estimation methods for analyzing SMPS reads produced by fluorosequencing. A Hidden Markov Model (HMM) based approach, extends
The mechanism for the CO substitution reaction involving diosmium carbonyl sawhorse complex Os2(μ-O2CH)2(CO)6, which contains an Os-Os single bond, two axial ligands, and four equatorial was investigated experimentally theoretically. Kinetic measurements show 13CO proceeding by a dissociative that is first-order in zero-order but with unexpectedly negative entropy of activation. corresponding electronic structure calculations yield enthalpy activation dissociation much larger than determined...