A5054773958- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Atomic and Subatomic Physics Research
- Growth Hormone and Insulin-like Growth Factors
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Regulation of Appetite and Obesity
- PARP inhibition in cancer therapy
- Alzheimer's disease research and treatments
- Pharmacological Receptor Mechanisms and Effects
- GDF15 and Related Biomarkers
Victor Chang Cardiac Research Institute
2021-2024
University of Newcastle Australia
2016-2021
Hunter Medical Research Institute
2018-2021
Cognitive impairment is a common outcome for stroke survivors. Growth hormone (GH) could represent potential therapeutic option as this peptide has been shown to improve cognition in various clinical conditions. In study, we evaluated the effects of peripheral administration GH at 48 hours poststroke 28 days on cognitive function and underlying mechanisms.Experimental was induced by photothrombotic occlusion young adult mice. We assessed associative memory domain using mouse touchscreen...
Hydroxychloroquine, chloroquine and azithromycin are three drugs that were proposed to treat coronavirus disease 2019 (COVID-19). While concern already existed around their proarrhythmic potential, there little data regarding how altered physiological states encountered in patients such as febrile state, electrolyte imbalances or acidosis might change risk profiles.Potency of human ether-à-go-go related gene (hERG) block was measured using high-throughput electrophysiology the presence...
Cognitive impairment is a common and disruptive outcome for stroke survivors, which recognized to be notoriously difficult treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function limits secondary neuronal loss in the thalamus after experimental stroke. There also emerging evidence LOPC may improve cognitive post-stroke. In current study aimed explore how exposure cognition Experimental was induced using photothrombotic occlusion adult, male C57BL/6...
Abstract Post-stroke cognitive impairment has proven to be notoriously difficult treat. In the current study, we sought both better understand cellular changes that underpin deficits and consider potential restorative benefits of low oxygen post conditioning (LOPC). We were motivated use LOPC as an intervention it is one few experimental interventions previously shown improve function post-stroke. Experimental stroke was induced by photothrombotic occlusion in adult male C57BL/6 mice. Mice...
Background and Purpose: Hydroxychloroquine chloroquine, alone or in combination with azithromycin, have been proposed as therapies for COVID-19. However, there is currently scant inconsistent data regarding their proarrhythmic potential these patients. Moreover, risk profile the setting of altered physiological states encountered patients COVID-19 (i.e. febrile state, electrolyte imbalances, and/or acidosis) unknown. Experimental approach: Potency hERG block was measured using...