A5016492460- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Oral microbiology and periodontitis research
- Alcohol Consumption and Health Effects
- Ferroptosis and cancer prognosis
- Cardiovascular Disease and Adiposity
- Down syndrome and intellectual disability research
- Cytokine Signaling Pathways and Interactions
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Aldose Reductase and Taurine
- Metabolism, Diabetes, and Cancer
- Protein Kinase Regulation and GTPase Signaling
- Prenatal Substance Exposure Effects
- Dental Health and Care Utilization
Ajinomoto (Japan)
2011-2024
Hebei Rehabilitation Hospital
2017
Ajinomoto (United States)
2014
University of Zurich
2013
University of Basel
2012-2013
Swiss Integrative Center for Human Health
2013
University Hospital of Zurich
2013
Branched-chain amino acids (BCAA) supplementation has been reported to suppress the incidence of liver cancer in obese patients with cirrhosis or and diabetic model animals carcinogenesis. Whether BCAA directly suppresses cell proliferation hepatic tumor cells under hyperinsulinemic condition remain be defined. The aim this study was investigate effects on insulin-induced determine underlying mechanisms. suppressed H4IIE, HepG2 cells. In H4IIE cells, did not affect cycle progression but...
Perivascular adipose tissue (PVAT) wraps blood vessels and modulates vasoreactivity by secretion of vasoactive molecules. Mammalian target rapamycin complex 2 (mTORC2) has been shown to control inflammation is expressed in tissue. In this study, we investigated whether adipose-specific deletion rictor thereby inactivation mTORC2 PVAT may modulate vascular function increasing PVAT.Rictor, an essential component, was deleted specifically mouse (rictor(ad-/-)). Phosphorylation downstream Akt at...
Taurine deficiency has been suggested to contribute the pathogenesis and complications of advanced hepatic diseases. The molecular basis for a low level taurine associated with failure is largely unknown. Using carbon tetrachloride (CCl4)-induced cirrhotic rat model, we found that activity expression cysteine dioxygenase (CDO), rate-limiting enzyme in synthesis, were significantly decreased liver these rats. To investigate underlying mechanisms suppression, examined effects pathological...
Studies have shown that tumor cell amino acid metabolism is closely associated with lung adenocarcinoma (LUAD) development and progression. However, the comprehensive multi-omics features clinical impact of expression genes in LUAD microenvironment (TME) are yet to be fully understood.
Enhanced degradation of tryptophan (Trp) and thus decreased plasma Trp levels are common in several types cancers. Although it is well known that catabolism induced the tumor microenvironment by enzymes expressed cancer cells, immune or both, few studies have examined systemic pathophysiology. The present study aimed to evaluate both peripheral tissues using tumor-engrafted Copenhagen rats were s.c. inoculated with AT-2 rat prostate cells negative for expression catabolic enzymes. Liquid...
Individuals with Down syndrome (DS) are known to be highly susceptible periodontal disease, exhibiting a rapid progression and increased severity in younger age. They also at high risk for Alzheimer’s disease (AD) certain derived from amyloid-β (Aβ) accumulation. Periodontal DS individuals is related an impaired immune system, poor oral hygiene, gingival tissue abnormalities, salivary factors, microbial factors oxidative stress levels of radical oxygen resulting genetic abnormalities....