A5043910801- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Plant-Derived Bioactive Compounds
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- biodegradable polymer synthesis and properties
- Parasites and Host Interactions
- Natural Fiber Reinforced Composites
- Aortic Disease and Treatment Approaches
- Synthesis and properties of polymers
- IL-33, ST2, and ILC Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes and associated disorders
Cincinnati Children's Hospital Medical Center
2024
Inha University
2024
Santa Monica College
2021
New York State College of Veterinary Medicine
2021
Cornell University
2019-2021
Type 2 inflammation is associated with epithelial cell responses, including goblet hyperplasia, that promote worm expulsion during intestinal helminth infection. How these responses are regulated remains incompletely understood. Here, we show mice deficient in the prostaglandin D2 (PGD2) receptor CRTH2 and deficiency only nonhematopoietic cells exhibited enhanced clearance hyperplasia following infection Nippostrongylus brasiliensis. Small stem, goblet, tuft expressed CRTH2. CRTH2-deficient...
During valvulogenesis, cytoskeletal, secretory and transcriptional events drive endocardial cushion growth remodeling into thin fibrous leaflets. Genetic disorders play an important role in understanding valve malformations but only account for a minority of clinical cases. Mechanical forces are ever present, how they coordinate molecular cellular decisions remains unclear. In this study, we used osmotic pressure to interrogate compressive tensile stresses influence shape maturation. We...
Type 1 diabetes (T1D) results from insulin insufficiency due to the loss or dysfunction of pancreatic beta cells following T cell-mediated autoimmune attack. Currently only long-term therapy is daily exogenous replacement. The ideal curative approach durable restoration functional islets via transplantation. To date limiting factors impeding realization this goal lack a cost effective and limitless source high-quality suitable for transplantation ability provide islet graft acceptance...
While much is known about the genetic regulation of early valvular morphogenesis, mechanisms governing fetal growth and remodeling remain unclear. Hemodynamic forces strongly influence but it unknown whether or how they interact with valvulogenic signaling programs. Side-specific activity programs motivates hypothesis that shear stress pattern-specific endocardial controls elongation leaflets.We determined extension semilunar valve occurs via fibrosa sided proliferation. Low OSS was...
Objective: Throughout valvulogenesis, endocardial cells are sensitive to shear stress and relay mechanical information the underlying mesenchymal cells. Here, we hypothesize that shear-sensitive Notch1 activation promotes expression of chemokine receptor CXCR4 in turn regulates cell proliferation matrix compaction. Methods: We examined mouse models with conditional inactivation global deletion CXCR4. To examine requirement stress, performed left atrial ligation (LAL) ovo innovated a new flow...