A5050568239- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Dietary Effects on Health
- Diet and metabolism studies
- Hippo pathway signaling and YAP/TAZ
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Bariatric Surgery and Outcomes
- Congenital Heart Disease Studies
Cornell University
2019-2023
Syosset Hospital
2017-2019
New York State University College of Human Ecology
2019
China Medical University Hospital
2018
China Medical University
2018
Stony Brook University
2018
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% cases. Mechanical forces generated by beating hearts drive development, how these collectively determine remains incompletely understood. Here, we decouple the influence those on size shape, study role YAP pathway in determining shape. The low oscillatory shear stress promotes nuclear...
Abstract Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% cases. Mechanical forces generated by beating hearts drive development, how these collectively determine remains incompletely understood. Here we decouple the influence those on size shape, study role YAP pathway in determining shape. The low oscillatory shear stress promotes...
While much is known about the genetic regulation of early valvular morphogenesis, mechanisms governing fetal growth and remodeling remain unclear. Hemodynamic forces strongly influence but it unknown whether or how they interact with valvulogenic signaling programs. Side-specific activity programs motivates hypothesis that shear stress pattern-specific endocardial controls elongation leaflets.We determined extension semilunar valve occurs via fibrosa sided proliferation. Low OSS was...
OBJECTS To examine the prevalence of obesity and related metabolic factors in Tibetan immigrants living high altitudes. METHODS A total 149 aged 20 years over were recruited 2016 Ladakh, India. Anthropometric indices biochemical measured. Obesity classified by body mass index (BMI) was defined using World Health Organization Asia‐Pacific criteria. Metabolic syndrome (MetS) American Heart Association National Heart, Lung Blood Institute definitions. RESULTS Men older had greater height,...