A5055312536- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Sedative Agents
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Retinal Diseases and Treatments
- Mechanical Circulatory Support Devices
- Retinal Imaging and Analysis
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Neuroscience and Neuropharmacology Research
- Analytical Methods in Pharmaceuticals
- Renal function and acid-base balance
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism and Genetic Disorders
- Glaucoma and retinal disorders
- Pulmonary Hypertension Research and Treatments
- Hemodynamic Monitoring and Therapy
- Analytical Chemistry and Sensors
- Cardiac Arrest and Resuscitation
- Head and Neck Surgical Oncology
- Quinazolinone synthesis and applications
- Nuclear and radioactivity studies
- Bone Tumor Diagnosis and Treatments
Ogaki Municipal Hospital
2015-2024
Nagoya University
2024
Aichi Medical University Hospital
2022-2024
Aichi Medical University
2022
Tokyo Women's Medical University
2018-2021
Bioengineering Center
2017
National Center for Genetic Engineering and Biotechnology
2017
John Wiley & Sons (United States)
2017
Hudson Institute
2017
Nissan Chemical Corporation (Japan)
1991-1999
Purpose To diagnose central serous chorioretinopathy (CSC) by deep learning (DL) analyses of en face images the choroidal vasculature obtained optical coherence tomography (OCT) and to analyze regions interest for DL from heatmaps. Methods One-hundred eyes were studied; 53 with CSC 47 normal eyes. Volume scans 12×12 mm square at same time as OCT angiographic (OCTA) (Plex Elite 9000 Swept-Source ® , Zeiss). High-quality segmentation slab one-half subfoveal thickness created analyses. The 100...
The incidence of postoperative nausea and vomiting (PONV) remains high, improving the accuracy PONV prediction challenging. primary aim this study is to examine impact anxiety scores evaluated using Hospital Anxiety Depression Scale (HADS) on model. We hypothesized that depression, quantified HADS, could improve predictive This pilot 100 patients. HADS was conducted by a self-evaluation method before thoracoscopic surgery for lung tumors, anesthesia standardized. criterion whether nurse in...
The effects of a new dihydropyridine derivative, NZ-105, on renal function were investigated in anesthetized spontaneously hypertensive rats. Intravenous injection NZ-105 (0.01 and 0.03 mg/kg body weight) significantly increased the urine flow rate (UV) absolute excretion sodium chloride. Potassium also significantly, but it was relatively slight comparison with or chloride excretion. There decrease mean blood pressure (-14.5 +/- 2.3 -22.3 3.4 mm Hg, 20 min after administration 0.01 weight,...
Anatomically corrected malposition of the great arteries (ACM) is an extremely uncommon cardiac disease in which arise from their appropriate ventricles despite abnormal spatial interrelations. Two patients with this malformation underwent successful surgical intervention for associated anomalies. One was situs solitus, d-loop and l-malposition other inversus, l-loop d-malposition arteries. Fifty-three cases accurate anatomical description were collected literature, characteristics anomalies...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and pharmacological studies of N-substituted 6-[(2-aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinediones, novel class III antiarrhythmic agentsTsutomu Katakami, Tatsuro Yokoyama, Michihiko Miyamoto, Haruki Mori, Nobuya Kawauchi, Tadahito Nobori, Kunio Sannohe, Tatsuo Kaiho, Joji KamiyaCite this: J. Med. Chem. 1992, 35, 18, 3325–3330Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published...
The antihypertensive effects of NIP-121, a novel potassium channel opener, were examined in comparison with cromakalim and its active enantiomer, le-makalim. In experiments by direct blood pressure measurements, orally administered NIP-121 dose-relatedly decreased arterial conscious spontaneously hypertensive rats (SHRs), the ED20 values (the doses to produce 20% decrease mean pressure) 0.010 0.11 mg/kg. respectively, thus being about ten times more potent than cromakalim. duration...
Pyomyositis is a bacterial infection of skeletal muscle leading to abscess formation. Younger males are predominantly involved, but pyomyositis may occur in all ages and sexes. Underlying systemic disease or accompanying immunocompromised states increase the risk pyomyositis. This report 72-year-old, male, with uncontrolled diabetes mellitus, presenting initially as case orbital cellulitis. Magnetic resonance imaging confirmed presence an left lateral rectus. Antibiotic therapy was promptly...
症例は49歳，女性．健診で異常を指摘され精査目的で当院を受診した．腹部造影CTで上腸間膜動脈（SMA）の右腹側に境界明瞭で造影効果を伴わない20×20mmの腫瘤を認めた．EUS-FNA検査ではわずかに末梢神経様の間質が認められた．MRI検査ではT1強調で低信号，T2強調で高信号，dynamic studyでは辺縁が早期に濃染し，後期相にかけて腫瘤が明瞭化した．以上の所見より後腹膜原発の神経鞘腫を第一に考え，腹腔鏡下腫瘍摘出術を施行した．術中所見では，腫瘍は脾静脈と下腸間膜静脈に接しており，SMA神経叢と連続していた．病理所見では，c-kit・CD34・α-SMAの免疫染色では染まらず，S-100蛋白で染まる紡錘形細胞の核や細胞質を認め，神経鞘腫と診断した．SMA神経叢に発生する神経鞘腫を腹腔鏡下に摘出しえたので報告する．
An 80-year-old female complained of diplopia after undergoing cataract surgery. On the first examination, adduction and abduction were slightly restricted. Magnetic resonance imaging revealed a mass in medial rectus muscle. The results pathological examination specimen harvested from corresponded to granular cell tumor. Although we could not completely excise because firm adhesion muscle, there was no recurrence without any suspicious metastatic lesion at 2.5 years follow-up.
Effect of efonidipine, a long-acting dihydropyridine derivative, on the endothelin-1 (ET-1)-induced coronary vasoconstriction was studied in open-chest anesthetized dogs. Efonidipine (0.03 or 0.1 mg/kg) administered i.v. 10 min before an intracoronary injection ET-1 (30 pmol/kg). An decreased blood flow (CBF) that measured by probe. The ET-1-induced decrease CBF sustained for more than 30 without significant changes pressure and heart rate. Pretreatment with efonidipine attenuated induced...
麻酔開胸イヌを用いて，ジヒドロピリジン系カルシウム拮抗薬の塩酸エホニジピンの心筋酸素需給バランスにおよぼす効果をニフェジピンおよびニソルジピンと比較検討した．麻酔開胸イヌにおいて塩酸エホニジピン（30μg/kg）はニフェジピン（3μg/kg）およびニソルジピン(3μg/kg)と同程度平均血圧を低下させたが，その降圧効果はニフェジピンおよびニソルジピンよりも持続的であった．そのとき心拍数は塩酸エホニジピンおよびニソルジピンにより減少したのに対しニフェジピンでは逆に増加した．心筋酸素消費量は塩酸エホニジピン（30μg/kg）により投与初期に軽度増加したが，その後は有意な変化は認められず一過性の反応であった．一方，ニフェジピン（1および3μg/kg）では投与直後に有意な増加が認められたのに対しニソルジピン（3μg/kg）では有意な変化は認められなかった．しかし塩酸エホ=ジピン，ニフェジピンおよびニソルジピンはともに冠状静脈洞血流量を増加させ動静脈酸素濃度較差を減少させたことより，これらの薬剤はともに心筋への酸素供給を増加させることが示唆された．また塩酸エホニジピン，ニフェジピンおよびニ...
Summary— Efonidipine is a dihydropyridine derivative having vasodilating action, which slower in onset and longer duration than that of nifedipine. In the present study, we compared effects efonidipine with those nifedipine on ischemic myocardial metabolism anesthetized dogs. The heart was made by ligating left anterior descending coronary artery (LAD) completely for 3 or 30 min. injected intravenously, 10 min, respectively, before start LAD occlusion. (0.01 0.03 mg/kg) decreased both blood...
Factors affecting the surgical results of total anomalous pulmonary venous drainage were evaluated in 17 patients an attempt to establish appropriate plan management. The mortality rate correlated with age, size interatrial communication, arterial oxygen saturation and left heart volume but not systemic systolic pressure ratio, vascular resistance ratio right ventricular volume. In cases where symptoms appeared early life, was small clinical features severe. Four children a end-diastolic...
Effects of efonidipine hydrochloride (NZ-105), a dihydropyridine calcium antagonist, on the cardiovascular system were studied in dogs, which left anterior descending coronary artery (LAD) was ligated for 50 min. NZ-105 (10 or 30 micrograms/kg), nifedipine (NIF, 1 3 micrograms/kg) nisoldipine (NIS, injected i.v. before LAD ligation. NZ-105, NIS NIF decreased total peripheral resistance (TPR) and blood pressure (BP) increased cardiac output (CO) regional myocardial flow (RBF)...