A5024223755- Birth, Development, and Health
- Diet and metabolism studies
- Gut microbiota and health
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Retinoids in leukemia and cellular processes
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Vitamin D Research Studies
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- Digestive system and related health
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Bacterial Identification and Susceptibility Testing
- Pregnancy and Medication Impact
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
University of Guelph
2021-2025
Utah State University
2016-2020
Cornell University
2015-2017
University of Toronto
2010-2016
Kraft Heinz (United States)
2010
Ingredion (United States)
2010
Scope Trimethylamine‐ N ‐oxide (TMAO), a metabolite linked to the gut microbiota, is associated with excess risk of heart disease. We hypothesized that (i) TMAO response animal source foods would vary among healthy men and (ii) this be modified by their microbiome. Methods results A crossover feeding trial in young ( n = 40) was conducted meals containing (fish), its dietary precursors, choline (eggs) carnitine (beef), fruit control. Fish yielded higher circulating urinary concentrations...
Excess vitamins, especially folate, are consumed during pregnancy but later-life effects on the offspring unknown. High multivitamin (10-fold AIN-93G, HV) gestational diets increase characteristics of metabolic syndrome in Wistar rat offspring. We hypothesized that vitamin active DNA methylation, accounts for these through epigenetic modification food intake regulatory genes. Male dams fed 10-fold folate (HFol) diet and weaned to recommended (RV) or HFol were compared with those born RV 29...
Background: Trimethylamine-N-oxide (TMAO), a choline-derived gut microbiota-dependent metabolite, is newly recognized risk marker for cardiovascular disease. We sought to determine: (1) TMAO response meals containing free versus lipid-soluble choline and (2) effects of microbiome on response. Methods: In randomized, controlled, double-blinded, crossover study, healthy men (n = 37) were provided 600 mg either as bitartrate or phosphatidylcholine, no control. Results: Choline yielded...
Abstract Background: Obesity is associated with increased consumption and preference for dietary fat. Experimental models of fat-induced obesity use either lard or vegetable shortening. Yet, there are no direct comparisons these commonly used fat sources, the influence their fatty acid composition, on development diet-induced obesity. Objective: To compare effects hydrogenated vegetable-shortening diets, which differ in weight gain insulin resistance rats. Methods design: Male Wistar rats...
NAD+ is essential for redox reactions in energy metabolism and necessary DNA repair epigenetic modification. Humans require sufficient amounts of dietary niacin (nicotinic acid, nicotinamide, nicotinamide riboside) adequate synthesis. In contrast, mice easily generate solely from tryptophan through the kynurenine pathway. We show that transgenic with inducible expression human alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) become dependent similar to humans when ACMSD...
High multivitamin (HV, tenfold AIN-93G) gestational diets fed to Wistar rats increase food intake, obesity, and characteristics of metabolic syndrome in the offspring. We hypothesized that methyl vitamins, specifically folate, HV diet contribute obesogenic phenotypes consistent with their epigenetic effects on hypothalamic intake regulatory mechanisms.Male offspring dams AIN-93G high vitamins (HMethyl; B12, B6) (Study 1) recommended folate (HVRF) 2) were compared those from vitamin (RV)...
ABSTRACT The gut microbiota is amenable to early nutrition including micronutrients but intake above and below the recommendations commonly occur with unknown consequences. Serotonin (5‐hydroxytryptamine [5‐HT]) a monoamine found centrally peripherally diverse functions such as food regulation via hypothalamic 5‐HT receptor 2C (5‐HTR2C). This study determined impact of prenatal on serotonergic system in offspring. Pregnant Wistar rats were fed either recommended vitamins (RV), high (HV),...
Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not female, offspring. These outcomes may be modulated by another methyl nutrient choline attributed the gut microbiota. Pregnant Wistar rats were fed an AIN-93G diet with recommended (RV), high 10-fold multivitamin (HV), (HFol) or without (HFol-C) content. Male female offspring weaned a high-fat RV 12 weeks post-weaning. Removing from HFol gestational...
Rats fed gestational diets high in multivitamin or folate produce offspring of altered phenotypes. We hypothesized that female rat born to dams a diet folic acid (HFol) have compromised bone health and feeding the same HFol attenuates these effects. Pregnant rats were with either recommended (RFol) 10-fold higher amounts. Female weaned RFol for 17 weeks. maternal resulted lower body weights (6%, P = 0.03) and, after adjusting weight femoral length, smaller area (2%, 0.03), compared control...
Obesity and insulin resistance (IR) are associated with epigenetic changes of gene expression. However, the relationship between micronutrients, regulation expression, IR during development diet-induced obesity has yet to be defined. Our objective is describe effect micronutrient addition diets on its related genes development.Male C57BL/6J mice fed a high-fat (HFD) or low-fat (LFD) without multi-vitamin mineral mix (MVM) containing vitamins A, B1, B6, B12, Zn, Se for 9 weeks. Compared LFD...