Bioactive materials, able to induce hydroxyapatite precipitation in contact with body fluids, are of great interest for their bone bonding capacity. . The aim this paper is compare bioactive materials different surface features verify the mechanisms action and relationship kinetics type precipitated over time. Four treatments Ti/Ti6Al4V alloy a glass were selected mechanism bioactivity supposed each them. Apart from conventional techniques (FESEM, XPS EDX), less common characterizations...

Surface properties of biomaterials (e.g., roughness, chemical composition, charge, wettability, and hydroxylation degree) are key features to understand control the complex interface phenomena that happens upon contact with physiological fluids. Numerous physico-chemical techniques can be used in order investigate depth these crucial material features. Among them, zeta potential measurements widely for characterization colloidal suspensions, but actually poorly explored study solid surfaces,...

It is widely recognized that surface nanotextures applied on a biomaterial can affect wettability, protein absorption and cellular and/or bacterial adhesion; accordingly, they are nowadays of great interest to promote fast osseointegration maintain physiological healing around biomedical implants. In order be suitable for clinical applications, must not only safe effective, but also, should produced through industrial processes scalable real devices with sustainable costs: this often barrier...

Bioactive materials should maintain their properties during implantation and for long time in contact with physiological fluids tissues. In the present research, five different bioactive (a glass four chemically treated titanium surfaces) have been studied compared terms of mechanical stability surface layer-substrate interface, term bioactivity, type hydroxyapatite matured hydroxyapatite-surface layer interface. Numerous physical chemical analyses (such as Raman spectroscopy, macro micro...

A chemically-treated titanium alloy (Ti6Al4V) surface, able to induce hydroxyapatite precipitation from body fluids (inorganic mineralization activity), was functionalized with a polyphenolic extract green tea (tea polyphenols, TPH). Considering that polyphenols have stimulating effects on bone forming cells (biological mineralization), the aim test their osteoinductive behavior due co-operation of inorganic and biological mesenchymal stem KUSA A1. The surfaces were characterized by using...

The focus of the paper is on effectiveness a functionalization process with natural polyphenols chemically treated and bioactive Ti6Al4V alloy, grafting mechanism, redox/scavenging activity grafted biomolecules. Polyphenols (phenolic acids, flavonoids, condensed tannins) are extracted from organic red grape pomace. performed at pH = 7.4 addition calcium ions, which act as bridge between substrate polyphenols. presence, amount (semi-quantitative), distribution, release, type bonding to...

Bioactive glasses (BGs) are attractive materials for bone replacement due to their tailorable chemical composition that is able promote healing and repair. Accordingly, many attempts have been introduced further improve BGs’ biological behavior protect them from bacterial infection, which nowadays the primary reason implant failure. Polyphenols natural products proposed as a novel source of antibacterial agents, whereas silver well-known agent largely employed its broad-ranged activity....

Abstract An extract of polyphenols was obtained from organic red grape pomace, chemically analyzed, and used for functionalization two bioactive glasses porous hydroxyapatite. Functionalization is effective on hydroxyapatite the glass with higher surface reactivity a different grafting mechanism. Grafting does not inhibit redox radical scavenging activity polyphenols. The grafted make continuous layer an almost complete coverage. Polyphenols are released kinetics according to mechanism...

This research aims toward an antibacterial and osteoconductive Ti 6 Al 4 V surface by chemical etching–oxidation treatment in situ reduction of silver nanoparticles. Starting from a previously developed process, already proved to enhance the osteoinductive ability titanium, different parameters are changed tailor amount its distribution across oxide layer thickness. The samples characterized scanning transmission electron microscopy, energy‐dispersive X‐ray spectroscopy, release silver,...

Despite increasing interest in the use of natural biomolecules for different applications, few attempts coupling them to inorganic biomaterials are reported literature. Functionalization metal implants with could allow a local action, overcoming issue low bioavailability through systemic administration. In present work, gallic acid was grafted pre-treated Ti6Al4V order improve its biological response bone contact applications. The grafting procedure optimized by choosing concentration (1...

Different surface treatments, with and without silver (Ag), of a Ti6Al4V alloy for increased bone bonding ability were investigated compared non-treated surfaces. Studies conducted at 37 °C in phosphate buffered saline (PBS, pH 7.4) varying hydrogen peroxide (H2O2) bovine serum albumin (BSA) concentrations. Increased levels metal release corrosion observed the presence both H2O2 BSA due to complexation Ti Al oxide, respectively. Ag was enhanced by BSA. Galvanic effects minor, but possibly...

A coating that was made of peppermint essential oil obtained on different metal substrates: Ti6Al4V alloy (mechanically polished and chemically etched) 316L stainless steel mechanically ground). The final aim is to get a multifunctional (chemical mechanical) protection surfaces in contact with water media. coatings were characterized by means fluorescence microscopy, angle measurements, Fourier Transformed Infrared spectroscopy (FTIR) spectroscopy. chemical stability the tested soaking for...

Temporomandibular joint (TMJ) involvement is common but usually delayed in patients with juvenile idiopathic arthritis (JIA). We describe the case of a JIA patient bilateral TMJ involvement, mandibular retrognathia, bone erosion, and severely restricted mouth opening. The use cone beam computed tomography 3D diagnostic protocol young provides reliable, accurate precise quantitative data images condylar structures their dimensional relationships. Analgesics conventional disease modifying...

Essential oils (EO) are complex mixtures of natural molecules with a great activity against bacteria, virus and fungi. Despite their wide use in folk medicine, employment medicine or biomedical products is still scarce there only few studies literature. Their antibacterial anti-adhesive properties interest for the development coatings functionalization implant surfaces, but also non-implantable medical devices, advantage reduced bacterial contamination, without risk developing bacteria...

Bud extracts are a new category of vegetal products, which used in gemmotherapy. These products liquid preparation sources bioactive molecules (phytochemicals) and medicine as health-promoting agents. Rosa canina is medicinal plant belonging to the family Rosaceae. The R. bud extracts, particular, possess anti-inflammatory antioxidant activities due presence flavonoids other phenolic compounds. combination with biomaterials can be promising for obtaining multifunctional materials carrying...

Abstract Durch Kondensation von Aminothiadiazolen (I) mit Halogenketoestern (II) erhält man Imidazo‐thiadiazole (III), deren Estergruppe teilweise alkalisch zur entsprechenden Säuregruppe verseift wurde.

Even though zeta potential titration is widely employed for investigation of colloidal suspensions, it still poorly applied to bulk solid surfaces.The measurement can be surfaces in contact with water-based media, and gives information about the isoelectric point surfaces, surface charge function pH, functional groups exposed on surface, adsorption/desorption processes at solid-liquid interface.Zeta vs pH useful applications such as membranes, filters, biomaterials, semiconductors, textile...