A5068791682- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Analytical chemistry methods development
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Additive Manufacturing and 3D Printing Technologies
- Collagen: Extraction and Characterization
- Polymer Surface Interaction Studies
- Analytical Chemistry and Chromatography
- 3D Printing in Biomedical Research
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Nanoparticle-Based Drug Delivery
- Engineering Technology and Methodologies
- Enzyme Production and Characterization
- Polysaccharides Composition and Applications
- Enzyme Catalysis and Immobilization
- Polymer Nanocomposites and Properties
- Dental materials and restorations
- Nanocomposite Films for Food Packaging
- Polymer Science and PVC
- Orthopaedic implants and arthroplasty
- Microplastics and Plastic Pollution
University of Pisa
2014-2023
National Interuniversity Consortium of Materials Science and Technology
2019-2023
Institute for Chemical and Physical Processes
2019-2023
National Research Council
2022
Piaggio (Italy)
2005
CNH Industrial (Italy)
2004
Industriale Chimica (Italy)
1994
Bioactive materials, able to induce hydroxyapatite precipitation in contact with body fluids, are of great interest for their bone bonding capacity. . The aim this paper is compare bioactive materials different surface features verify the mechanisms action and relationship kinetics type precipitated over time. Four treatments Ti/Ti6Al4V alloy a glass were selected mechanism bioactivity supposed each them. Apart from conventional techniques (FESEM, XPS EDX), less common characterizations...
Bioartificial blends of poly-(ε-caprolactone) (PCL) with a polysaccharide (starch, S; dextran, D; or gellan, G) (PCL/S, PCL/D, PCL/G 90.9/9.1 wt ratio) were prepared by solution−precipitation technique and widely characterized differential scanning calorimetry analysis (DSC), Fourier transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), optical microscopy (OM), wide-angle X-ray diffraction (WAXD), thermogravimetry (TGA). DSC showed that the reduced crystallinity PCL had...
Abstract The aim of this work was the preparation blends based on alginate and gelatin, with different weight ratio, to combine advantages these two natural polymers for application in cardiac tissue engineering. physicochemical characterization, performed by Fourier transform infrared spectroscopy, differential scanning calorimetry thermogravimetric analysis, revealed a good miscibility presence interactions among functional groups pure biopolymers. Concerning swelling degradation tests,...
Tissue engineering has emerged as a viable approach to treat disease or repair damage in tissues and organs. One of the key elements for success tissue is use scaffold serving artificial extracellular matrix (ECM). The ECM hosts cells improves their survival, proliferation, differentiation, enabling formation new tissue. Here, we propose development class protein/polysaccharide-based porous scaffolds substitutes cardiac engineering. Scaffolds based on blends protein component, collagen...
In this study biomimetic poly(glycerol sebacate) PGS matrix was developed for cardiac patch application. The rationale that such matrices would provide conducive environment the seeded cells at interphase with PGS. From microstructural standpoint, fabricated into dense films and porous scaffolds. biological aspect, membranes were via covalently binding peptides Tyr-Ile-Gly-Ser-Arg (YIGSR) Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), corresponding to epitope sequences of laminin fibronectin,...
Scaffolds for cardiac patch application must meet stringent requirements such as biocompatibility, biodegradability, and facilitate vascularization in the engineered tissue. Here, a bioactive, biocompatible, biodegradable electrospun scaffold of poly(glycerol sebacate)–poly(ε‐caprolactone) (PGS–PCL) is proposed potential application. The fibers are smooth bead free with average diameter = 0.8 ± 0.3 μm, mean pore size 2.2 1.2 porosity 62 4%, permeability higher than that control biological...
Chemotherapeutics represent the standard treatment for a wide range of cancers. However, these agents also affect healthy cells, thus leading to severe off-target effects. Given non-selectivity commonly used drugs, any increase in selective tumor tissue uptake would significant improvement cancer therapy. Recently, use gene therapy completely remove lesion and avoid toxicity chemotherapeutics has become tendency oncotherapy. Ideally, genetic material must be safely transferred from site...
Abstract Three‐dimensional porous hydroxyapatite/collagen (HA/Coll) composites with a random pore structure were obtained by freeze‐drying and crosslinked an enzymatic treatment using microbial transglutaminase (mTGase). The procedure resulted in improved mechanical strength thermal stability of the scaffolds. scaffolds characterized terms their (Coll release, swelling, collagenase‐mediated degradation), properties (thermogravimetric analysis, differential scanning calorimetry), behavior...
Bioactive materials should maintain their properties during implantation and for long time in contact with physiological fluids tissues. In the present research, five different bioactive (a glass four chemically treated titanium surfaces) have been studied compared terms of mechanical stability surface layer-substrate interface, term bioactivity, type hydroxyapatite matured hydroxyapatite-surface layer interface. Numerous physical chemical analyses (such as Raman spectroscopy, macro micro...
Cross-linked gelatin/hydroxyapatite/bioactive glass (G/HA/CEL2) films with different compositions (100:0:0 (G1); 30:70:0 (G2); 30:0:70 (G3); 30:35:35 (G4) (%, w/w/w)) were prepared as scaffold materials for tissue-engineering applications, particularly in the field of bone repair. A bioactive 45% SiO2, 3% P2O5, 26% CaO, 7% MgO, 15% Na2O and 4% K2O molar composition was selected (CEL2). Genipin used a cross-linker gelatin component. Samples characterized terms their bioactivity, thermal...
The interactions between soluble collagen (C) from calf skin and poly(acrylic acid) (PAA) were studied. Mixing aqueous solutions of PAA, at various pH values (2.5–4), leads to the formation complexes that precipitate in form insoluble aggregates. effects mixture composition, pH, ionic strength on C/PAA complex investigated by gravimetric, turbidimetric, conductometric analysis. experimental results indicate through electrostatic interactions. Homogeneous solid films with variable ratios...
The preparation of new polymeric membranes using molecular imprinting technology for application in blood filtration devices is described. Membranes, based on an acrylic acid-acrylonitrile copolymer, produced through phase inversion, were modified by introducing specific binding sites uric acid into their structure. materials prepared are intended use to selectively remove from the case increased serum values associated with different pathologies. interactions at a level between membrane...