A5084489232- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Neurotoxicity Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- Adenosine and Purinergic Signaling
- Paraoxonase enzyme and polymorphisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
University of Turin
2015-2024
Ospedale San Luigi Gonzaga
2011-2015
King's College London
2013
Istituto Nazionale per le Ricerche Cardiovascolari
2009-2010
Brigham and Women's Hospital
2008
Harvard University
2008
University of Louisville
2005-2008
University of Amsterdam
2006
Centro Cardiologico Monzino
2005
Istituto Dermopatico dell'Immacolata
2005
Cardiac stem cells and early committed (CSCs-ECCs) express c-Met insulin-like growth factor-1 (IGF-1) receptors synthesize secrete the corresponding ligands, hepatocyte factor (HGF) IGF-1. HGF mobilizes CSCs-ECCs IGF-1 promotes their survival proliferation. Therefore, were injected in hearts of infarcted mice to favor, respectively, translocation from surrounding myocardium dead tissue viability these within damaged area. To facilitate migration homing infarct, a gradient was introduced...
The ability of cardiac stem cells (CSCs) to promote myocardial repair under clinically relevant conditions (i.e., when delivered intravascularly after reperfusion) is unknown. Thus, rats were subjected a 90-min coronary occlusion; at 4 h reperfusion, CSCs the arteries via catheter positioned into aortic root. Echocardiographic analysis showed that injection attenuated increase in left ventricular (LV) end-diastolic dimensions and impairment LV systolic performance 5 weeks infarction....
Ischemic heart disease is characterized chronically by a healed infarct, foci of myocardial scarring, cavitary dilation, and impaired ventricular performance. These alterations can only be reversed replacement scarred tissue with functionally competent myocardium. We tested whether cardiac progenitor cells (CPCs) implanted in proximity infarcts or resident CPCs stimulated locally hepatocyte growth factor insulin-like factor-1 invade the myocardium generate myocytes coronary vessels improving...
High-mobility group box 1 protein (HMGB1) is a chromatin that released by inflammatory and necrotic cells. Extracellular HMGB1 signals tissue damage, stimulates the secretion of proinflammatory cytokines chemokines, modulates stem cell function. The present study examined exogenous effect on mouse left-ventricular function myocyte regeneration after infarction. Myocardial infarction was induced in C57BL/6 mice permanent coronary artery ligation. After 4 hours animals were reoperated 200 ng...
Postconditioning (PostC) maneuvers allow post-ischemic accumulation of autacoids, which trigger protection. We tested if PostC-triggering includes bradykinin (BK) B2 receptor activation and its downstream pathway.Isolated rat hearts underwent 30 min ischemia 120 reperfusion. Infarct size was evaluated using nitro-blue tetrazolium staining. In Control infarct 61+/-5% risk area. PostC (5 cycles 10 s reperfusion/ischemia) reduced to 22+/-4% (p<0.01). protection abolished by BK...
We studied whether apelin-13 is cardioprotective against ischemia/reperfusion injury if given as either a pre- or postconditioning mimetic and the improved postischemic mechanical recovery induced by depends only on reduced infarct size also of function viable myocardium. nitric oxide (NO) involved in apelin-induced protection reported ischemia-induced overexpression apelin receptor (APJ) plays role cardioprotection. Langendorff-perfused rat hearts underwent 30 min global ischemia 120...
Chemotherapeutics represent the standard treatment for a wide range of cancers. However, these agents also affect healthy cells, thus leading to severe off-target effects. Given non-selectivity commonly used drugs, any increase in selective tumor tissue uptake would significant improvement cancer therapy. Recently, use gene therapy completely remove lesion and avoid toxicity chemotherapeutics has become tendency oncotherapy. Ideally, genetic material must be safely transferred from site...
The acidic protein chromogranin A (CgA) is the precursor of several regulatory peptides generated by specific proteolytic processes. Human recombinant CgA NH 2 -terminal fragment STA-CgA 1-78 (hrSTA-CgA ), containing vasostatin-1 (CgA 1-76 ) domain, exerts a negative inotropic effect and counteracts β-adrenergic positive on rat heart. We hypothesized an involvement nitric oxide (NO)-dependent pathway in both cardiodepression cardioprotection hrSTA-CgA . also adenosine 1 receptor kinase C...
Depending on their concentrations, both nitric oxide (NO) and reactive oxygen species (ROS) take part either in myocardial ischemia reperfusion injury or protection by ischemic pharmacological preconditioning (Ipre) postconditioning (Ipost). At the beginning of reperfusion, a transient release NO is promptly scavenged ROS to form highly toxic peroxynitrite, which responsible for further increase through endothelial synthase uncoupling. The protective role has suggested use donors mimic Ipre...
Apelin, the ligand of G-protein-coupled receptor (GPCR) APJ, exerts a post-conditioning-like protection against ischaemia/reperfusion injury through activation PI3K-Akt-NO signalling. The pathway connecting APJ to PI3K is still unknown. As other GPCR ligands act transactivation epidermal growth factor (EGFR) via matrix metalloproteinase (MMP) or Src kinase, we investigated whether EGFR involved in following three features apelin-induced cardioprotection: limitation infarct size, suppression...
Aim: To assess functional effects of silica nanoparticles (SiO2-NPs) on human mesenchymal stem cell (hMSC) cardiac integration potential. Methods: SiO2-NPs were synthesized and their internalization hMSCs analyzed with particular emphasis interaction the environment Results: SiO2-NP affected area maturation level hMSC focal adhesions, accounting for increased in vitro adhesion capacity augmented engraftment myocardial tissue upon injection infarcted isolated rat hearts. treatment also...