A5053718921- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Infective Endocarditis Diagnosis and Management
- Mesenchymal stem cell research
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Congenital heart defects research
- Cardiac Imaging and Diagnostics
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Cardiac pacing and defibrillation studies
- Peripheral Artery Disease Management
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cardiac Fibrosis and Remodeling
- Cardiac and Coronary Surgery Techniques
- Central Venous Catheters and Hemodialysis
- Aortic aneurysm repair treatments
- Complement system in diseases
- Blood groups and transfusion
- Cardiac Arrhythmias and Treatments
The University of Texas Health Science Center at Houston
2015-2024
Texas Medical Center
2015-2024
Memorial Hermann–Texas Medical Center
2020-2024
University of Maryland, Baltimore
2024
University of Maryland Medical Center
2024
Memorial Hermann
2015-2023
University of Kentucky
2020
Saint Luke's Health System
2015
Baylor College of Medicine
2013
St. Luke's Episcopal Hospital
2011
The identification of cardiac progenitor cells in mammals raises the possibility that human heart contains a population stem capable generating cardiomyocytes and coronary vessels. characterization (hCSCs) would have important clinical implications for management failing heart. We established conditions isolation expansion c- kit -positive hCSCs from small samples myocardium. Additionally, we tested whether these ability to form functionally competent myocardium after infarction...
The purpose of this study was to determine whether the heart in large mammals contains cardiac progenitor cells that regulate organ homeostasis and regenerate dead myocardium after infarction. We report dog possesses a stem cell pool characterized by undifferentiated are self-renewing, clonogenic, multipotent. These clonogenic early committed progeny possess hepatocyte growth factor (HGF)–c-Met an insulin-like 1 (IGF-1)-IGF-1 receptor system can be activated induce their migration,...
Cardiac stem cells and early committed (CSCs-ECCs) express c-Met insulin-like growth factor-1 (IGF-1) receptors synthesize secrete the corresponding ligands, hepatocyte factor (HGF) IGF-1. HGF mobilizes CSCs-ECCs IGF-1 promotes their survival proliferation. Therefore, were injected in hearts of infarcted mice to favor, respectively, translocation from surrounding myocardium dead tissue viability these within damaged area. To facilitate migration homing infarct, a gradient was introduced...
Recent studies in mice have challenged the ability of bone marrow cells (BMCs) to differentiate into myocytes and coronary vessels. The claim has also been made that BMCs acquire a cell phenotype different from blood lineages only by fusing with resident cells. Technical problems exist induction myocardial infarction successful injection mouse heart. Similarly, accurate analysis populations implicated regeneration dead tissue is complex these factors together may account for negative...
Cardiac stem cells (CSCs) have been identified in the adult heart, but microenvironment that protects slow-cycling, undifferentiated, and self-renewing CSCs remains to be determined. We report myocardium possesses interstitial structures with architectural organization of cell niches harbor long-term BrdU-retaining cells. The recognition label-retaining provides functional evidence resident myocardium, indicating heart is an organ regulated by a compartment. contain lineage-committed cells,...
The Notch receptor mediates cell fate decision in multiple organs. In the current work we tested hypothesis that Nkx2.5 is a target gene of Notch1 and raised possibility regulates myocyte commitment adult heart. Cardiac progenitor cells (CPCs) niches express receptor, supporting exhibit ligand Jagged1. nuclear translocation intracellular domain (N1ICD) up-regulates CPCs promotes formation cycling myocytes vitro . N1ICD RBP-Jk form protein complex, which turn binds to promoter initiating...
Because randomized coronary revascularization trials in stable artery disease (CAD) have shown no reduced myocardial infarction (MI) or mortality, the threshold of quantitative perfusion severity was analyzed for association with death, MI, stroke after within 90 d PET. <b>Methods:</b> In a prospective long-term cohort CAD, regional, artery-specific, by PET, and all-cause (DMS) at 9-y follow-up (mean ± SD, 3.0 2.3 y) were multivariate Cox regression models propensity analysis....
Abstract Background and Aims Coronary flow capacity (CFC) is associated with an observed 10-year survival probability for individual patients before after actual revascularization comparison to virtual hypothetical ideal complete revascularization. Methods Stress myocardial perfusion (mL/min/g) coronary reserve (CFR) per pixel were quantified in 6979 artery disease (CAD) subjects using Rb-82 positron emission tomography (PET) CFC maps of artery-specific size-severity abnormalities expressed...
The Impella CP (Abiomed Inc., Danvers, MA) is widely used in cardiac catheterization laboratories for patients presenting with cardiogenic shock, but it also known to cause significant hemolysis. risk of hemolysis can be reduced by properly positioning the device, ensuring an adequate volume status, and using full anticoagulation strategies; however, some cases persists. We present a case series eight that were diagnosed underwent placement, then suffered from refractory which was treated...
Bleeding associated with left ventricular assist device (LVAD) implantation has been attributed to the loss of large von Willebrand factor (VWF) multimers excessive cleavage by ADAMTS-13, but this mechanism is not fully supported current evidence. We analyzed VWF reactivity in longitudinal samples from LVAD patients and studied normal platelets exposed high shear stress show that became hyperadhesive induce platelet microvesiculation. Platelet microvesicles activated endothelial cells,...
Abstract Introduction Antegrade dissection and re‐entry (ADR) is an integral part of the hybrid algorithm, which has allowed for improved outcomes in chronic total occlusion (CTO) coronary intervention (PCI). Methods A new ADR method, Subintimal FEnestration Re‐entry (SAFER), described. The results a first‐in‐man series are presented. Results SAFER was performed on seven consecutive patients with angiographic clinical success all patients. Conclusions This study shown that technique feasible...
Frailty and malnutrition in patients with heart failure are barriers to durable left ventricular assist device (D-LVAD) support transplantation. Moreover, cachexia advanced carries a high mortality risk. There no guidelines for these other than increased caloric intake rehabilitation. Patients suffering from cardiac may benefit temporary, percutaneous improve the underlying disease reverse catabolic state. We retrospectively reviewed January 2017 2022. All who received Impella (5.0 or 5.5,...
Carcinoid heart disease presents as right-sided failure attributable to the dysfunction of tricuspid and pulmonary valves. Although surgical valve replacement is mainstay treatment when patients become symptomatic, it associated with substantial perioperative mortality rates. We present a case severe stenosis secondary carcinoid disease, treated successfully percutaneous replacement. A 67-year-old man was referred our center for The patient had history metastatic neuroendocrine tumor small...
Abstract Background Intraplaque delivery of contrast has been utilized during percutaneous coronary interventions (PCI) chronic total occlusions (CTO) to delineate anatomy and facilitate wire crossing. Its utility as a tool accomplish primary crossing CTOs not described or validated. Aims We describe new technique leveraging the diagnostic therapeutic roles intraplaque injection CTOs: HydroDynamic Recanalization (HDR). Methods HDR is an antegrade method for based on synergistic use...
Patients supported by left ventricular assist devices (LVADs) often present with the loss of large von Willebrand factor (VWF) multimers. This VWF deficiency is believed to contribute bleeding diathesis patients on LVAD support and caused excessive cleavage metalloprotease ADAMTS-13 under high shear stress. However, only a small percentage who have suffered multimers bleed. The actual rates in these not been reported, primarily because lack reliable detection methods. We developed validated...
A few case reports and series have documented the outcomes in patients with tricuspid bioprosthetic valvular degeneration who underwent transcatheter implantation of Medtronic M elody Edwards S apien XT 3 valves. In this report, we describe a 49-year-old woman severe stenosis multiple comorbidities valve replacement valve.
A 30 year-old Hispanic man with no significant previous medical history presented refractory hypoxemia after flu-like symptoms. Because of progressive despite appropriate ventilator strategies, venovenous extracorporeal membrane oxygenation (VV-ECMO) was initiated for severe acute respiratory distress syndrome (ARDS). His course complicated at our hospital by subarachnoid hemorrhage, right ventricular failure, multiple pneumothoraces, and deconditioning. He able to be weaned off VV-ECMO 193...