A5001870768- Tissue Engineering and Regenerative Medicine
- Chemotherapy-induced cardiotoxicity and mitigation
- Congenital heart defects research
- Diabetes Treatment and Management
- Electron Spin Resonance Studies
- Mesenchymal stem cell research
- Fire effects on ecosystems
- Cardiac Ischemia and Reperfusion
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Neuropeptides and Animal Physiology
- Cardiac Structural Anomalies and Repair
- Remote Sensing in Agriculture
- Neonatal Respiratory Health Research
- Land Use and Ecosystem Services
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Pluripotent Stem Cells Research
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
University of Campania "Luigi Vanvitelli"
2015-2024
University of Bari Aldo Moro
2023
Terra
2020
University of Florence
2020
Ospedale di Livorno
2020
Ambiente Italia (Italy)
2020
Swiss Federal Institute for Forest, Snow and Landscape Research
2020
Magna Graecia University
2020
Institut National des Langues et Civilisations Orientales
2014-2016
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria
2012-2013
The identification of cardiac progenitor cells in mammals raises the possibility that human heart contains a population stem capable generating cardiomyocytes and coronary vessels. characterization (hCSCs) would have important clinical implications for management failing heart. We established conditions isolation expansion c- kit -positive hCSCs from small samples myocardium. Additionally, we tested whether these ability to form functionally competent myocardium after infarction...
In this study, we tested whether the human heart possesses a cardiac stem cell (CSC) pool that promotes regeneration after infarction. For purpose, CSC growth and senescence were measured in 20 hearts with acute infarcts, end-stage postinfarction cardiomyopathy, 12 control hearts. number increased markedly and, to lesser extent, chronic infarcts. correlated increase telomerase-competent dividing CSCs from 1.5% controls 28% infarcts 14% The mitotic index 29-fold 14-fold committed myocyte,...
Cardiac stem cells and early committed (CSCs-ECCs) express c-Met insulin-like growth factor-1 (IGF-1) receptors synthesize secrete the corresponding ligands, hepatocyte factor (HGF) IGF-1. HGF mobilizes CSCs-ECCs IGF-1 promotes their survival proliferation. Therefore, were injected in hearts of infarcted mice to favor, respectively, translocation from surrounding myocardium dead tissue viability these within damaged area. To facilitate migration homing infarct, a gradient was introduced...
Cardiac stem cells (CSCs) have been identified in the adult heart, but microenvironment that protects slow-cycling, undifferentiated, and self-renewing CSCs remains to be determined. We report myocardium possesses interstitial structures with architectural organization of cell niches harbor long-term BrdU-retaining cells. The recognition label-retaining provides functional evidence resident myocardium, indicating heart is an organ regulated by a compartment. contain lineage-committed cells,...
Diabetes leads to a decompensated myopathy, but the etiology of cardiac disease is poorly understood. Oxidative stress enhanced with diabetes and oxygen toxicity may alter progenitor cell (CPC) function resulting in defects CPC growth myocyte formation, which favor premature myocardial aging heart failure. We report that model insulin-dependent mellitus, generation reactive species (ROS) telomeric shortening, expression senescent associated proteins p53 p16INK4a, apoptosis CPCs, impairing...
Ischemic heart disease is characterized chronically by a healed infarct, foci of myocardial scarring, cavitary dilation, and impaired ventricular performance. These alterations can only be reversed replacement scarred tissue with functionally competent myocardium. We tested whether cardiac progenitor cells (CPCs) implanted in proximity infarcts or resident CPCs stimulated locally hepatocyte growth factor insulin-like factor-1 invade the myocardium generate myocytes coronary vessels improving...
Background— Anthracyclines are the most effective drugs available in treatment of neoplastic diseases; however, they have profound consequences on structure and function heart, which over time cause a cardiomyopathy that leads to congestive heart failure. Methods Results— Administration doxorubicin rats led dilated myopathy, failure, death. To test whether effects cardiac anatomy were mediated by alterations progenitor cells (CPCs), these exposed anthracycline, increased formation reactive...
The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal models have been crucial exploring DCM pathophysiology while identifying potential therapeutic targets. Streptozotocin (STZ) has widely used to produce experimental both type 1 2 DM (T1DM T2DM). Here, we compared these two for their effects on cardiac structure, function transcriptome. Different doses STZ diet chows were...
Coronary artery disease is the most common cause of cardiac failure in Western world, and to date there no alternative bypass surgery for severe coronary atherosclerosis. We report that c-kit-positive progenitor cells (CPCs) activated with insulin-like growth factor 1 hepatocyte before their injection proximity site occlusion left rats, engrafted within host myocardium forming temporary niches. Subsequently, CPCs divided differentiated into endothelial smooth muscle and, a lesser extent,...
Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. We assessed hypothesis that senescence senescence-associated secretory phenotype (SASP) are main mechanisms degenerative defect in DM. Accordingly, we tested whether ablation senescent CSCs would rescue regenerative/reparative imposed by obtained tissue from nonaged (50- to 64-year-old) patients with type 2 diabetes (T2DM) without DM (NDM) postinfarct...
Cardiorenal syndrome encompasses a spectrum of disorders involving heart and kidney dysfunction, sharing common risk factors, such as hypertension diabetes. Clinical studies have shown that patients with without diabetes may benefit from using sodium-glucose cotransporter 2 inhibitors to reduce the failure ameliorate renal endpoints. Because underlying mechanisms remain elusive, we investigated effects dapagliflozin on progression damage, model non-diabetic cardiorenal disease. Dahl...