A5012233151- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Neuropeptides and Animal Physiology
- Collagen: Extraction and Characterization
- Gene Regulatory Network Analysis
- Pharmaceutical Practices and Patient Outcomes
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Silk-based biomaterials and applications
- Stress Responses and Cortisol
- Bone Tissue Engineering Materials
University of Bristol
2022-2024
MRC Brain Network Dynamics Unit
2022-2024
Medical Research Council
2022-2024
University of Oxford
2022-2024
University of Sussex
2017-2020
Sapienza University of Rome
2013-2017
European Brain Research Institute
2014
University of Pisa
2011
Abstract Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since also encodes other behavioural variables, it unclear how postsynaptic identify which event induce plasticity. Additionally, unknown released from arborised axons can potentiate targeted striatal through...
Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. Recent evidence suggests diversity signaling, yet it remains poorly understood how heterogeneous signals might be organized facilitate role of downstream circuits mediating distinct aspects behavior. Here, we investigated organizational logic dopaminergic signaling recording labeling individual midbrain during associative Our findings show that reward...
Clinical and preclinical evidence indicates that the setting of drug use affects reward in a substance-specific manner. Heroin cocaine co-abusers, for example, indicated distinct settings two drugs: heroin being used preferentially at home outside home. Similar results were obtained rats given opportunity to self-administer intravenously both cocaine.The goal present study was investigate possibility positive affective state induced by is enhanced when taken relative non-home environment,...
Abstract Despite the still prevailing notion of a shared substrate action for all addictive drugs, there is evidence suggesting that opioid and psychostimulant drugs differ substantially in terms their neurobiological behavioral effects. These differences may reflect separate neural circuits engaged by two drugs. Here we used catFISH (cellular compartment analysis temporal activity fluorescence situ hybridization) technique to investigate degree overlap between neurons heroin versus cocaine...
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations oral and vaginal mucosae. Virtually nothing known about central pharmacological actions BZY. Yet there are reports voluntary systemic overdosage BZY in addicts, resulting euphoric, hallucinatory state. In present study, we investigated reinforcing properties rat self-administration paradigm. We found that has powerful effect this greatly facilitated animals already had substance...
ABSTRACT Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. While this teaching signal is often considered be uniform, recent evidence instead supports diversity signaling. However, it remains poorly understood how heterogeneous signals might organized facilitate role of downstream circuits mediating distinct aspects behavior. Here we investigated organizational logic dopaminergic signaling recording labeling...
Avvisati, Riccardoa; Maria, Teresa De Lucaa; Montanari, Christiana; Parrino, Laura; Luisa Scattonib; Badiani, AldoaAuthor Information