A5061429900- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Nerve injury and regeneration
- Ion channel regulation and function
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
Lund University
2012-2020
Parkinson's disease (PD) patients experience loss of normal motor function (hypokinesia), but can develop uncontrollable movements known as dyskinesia upon treatment with L-DOPA. Poverty or excess movement in PD has been attributed to overactivity striatal projection neurons forming either the indirect (iSPNs) direct (dSPNs) pathway, respectively. Here, we investigated two pathways' contribution different features using SPN type-specific chemogenetic stimulation rodent models (PD mice) and...
In animal models of Parkinson′s disease, striatal overactivation ERK1/2 via dopamine (DA) D1 receptors is the hallmark a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate pathways involved in receptor-dependent activation using acute slices from rodents unilateral 6-hydroxydopamine (6-OHDA) lesions. Application D1-like receptor agonist SKF38393 induced phosphorylation and downstream signaling DA-denervated but not intact striatum. This was mediated...
Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy Parkinson's disease. Here we show that metabotropic glutamate type 5 (mGlu5) receptors can form previously unknown heteromeric entities with distinctive functional properties. Interacting Gq proteins, cell-surface D1-mGlu5 heteromers exacerbated PLC signaling intracellular calcium release response to either or dopamine. In rodent models disease,...
Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark Parkinson's disease (PD). Here we investigate how chronic dopamine denervation and replacement with L-DOPA affect the morphology physiology direct pathway SPNs (dSPNS) in rat striatum. We used lentiviral vector optimized for retrograde labeling (FuG-B-GFP) to identify dSPNs rats 6-hydroxydopamine (6-OHDA) lesions. Changes were assessed through combination patch-clamp recordings two photon microscopy....