A5061898447- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Estrogen and related hormone effects
- Caveolin-1 and cellular processes
- Air Quality and Health Impacts
- Nitric Oxide and Endothelin Effects
- Fatty Acid Research and Health
- Connexins and lens biology
- Neonatal and fetal brain pathology
- Folate and B Vitamins Research
- Smoking Behavior and Cessation
- Health, Environment, Cognitive Aging
- Neuroscience of respiration and sleep
- Menopause: Health Impacts and Treatments
- Renal function and acid-base balance
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Neonatal Respiratory Health Research
- Ion Transport and Channel Regulation
- Fusion and Plasma Physics Studies
- Child Development and Digital Technology
Wayne State University
2021-2025
Temple College
2022
Michigan United
2022
RELX Group (Netherlands)
2019-2022
Texas A&M University
2006-2021
In-Q-Tel
2020
Daejeon University
2019
University of Wisconsin–Madison
2009-2016
University of South Florida
2016
The University of Texas Medical Branch at Galveston
2012-2014
Estradiol-17β (E 2 β) and its metabolites, which are sequentially synthesized by cytochrome P450s catechol- O -methyltransferase to form 4-hydroxyestradiol (OHE ) 2- 4-methoxestradiol (ME ), elevated during pregnancy. We investigated whether expressed in uterine artery endothelial cells (UAECs) E β metabolites modulate cell proliferation via ER-α and/or ER-β play roles physiological angiogenesis Cultured ovine UAECs from pregnant nonpregnant ewes were treated with 0.1 100.0 nmol/L of β,...
Sex steroid hormones estradiol and progesterone play an important role in vascular adaptations during pregnancy. However, little is known about the of androgens. Plasma testosterone (T) levels are elevated preeclampsia, mothers with polycystic ovary, pregnant African American women, who have endothelial dysfunction develop gestational hypertension. We tested whether increased T alters pregnancy these alterations depend on endothelium-derived factors, such as prostacyclin, hyperpolarizing...
Current fetal alcohol spectrum disorders (FASD) studies primarily focus on alcohol's actions the brain although respiratory infections are a leading cause of morbidity/mortality in newborns. The limited examining pulmonary adaptations FASD demonstrate decreased surfactant protein A and alveolar macrophage phagocytosis, impaired differentiation, increased risk Group B streptococcal pneumonia with no study sexual dimorphism adaptations. We hypothesized that developmental exposure pregnancy...
Embryonic development is a time-sensitive period that requires synchronized uterine environment, which created by the secretion of proteins from both embryo and uterus. Numerous studies have identified luminal related these to specific adaptations during early pregnancy (EP). However, no study has yet utilized LC-MS/MS identify signature profile in lumen EP. In this study, fluid nonpregnant (NP; n = 3) EP (n 3; gestational day 16) ewes were analyzed validated Western immunoblotting. We...
Maternal immune activation (MIA) by environmental challenges is linked to severe developmental complications, such as neurocognitive disorders, autism, and even fetal/maternal death. Benzene a major toxic compound in air pollution that affects the mother well fetus has been associated with reproductive complications. Our objective was elucidate whether benzene exposure during gestation triggers MIA its impact on fetal development. We report pregnancy leads increased resorptions, growth,...
Metabolism of estradiol-17β to 2-hydroxyestradiol, 4-hydroxyestradiol, 2-methoxyestradiol, and 4-methoxyestradiol contributes importantly the vascular effects in several beds. However, little is known about role metabolites via different estrogen receptors (ER-α/ER-β) on de novo endothelial prostacyclin thromboxane production. We hypothesized that its metabolites, ER-α or ER-β, can enhance prostacyclin/thromboxane ratio through classic phospholipase A 2 , cyclooxygenase-1, synthase pathway...
Background: Human magnetic resonance imaging (MRI) and autopsy studies reveal abnormal cerebellar development in children who had been exposed to alcohol prenatally, independent of the exposure period. Animal conducted utilizing rat model similarly demonstrate a broad period vulnerability, albeit third trimester‐equivalent human brain is reported be most vulnerable period, first produces Purkinje cell loss only at high doses alcohol. However, model, all 3 trimester‐equivalents do not occur...
Background: The third trimester equivalent has been identified, both in rat and sheep models, as a period of cerebellar vulnerability to alcohol‐mediated injury. We wished determine whether alcohol exposure throughout gestation results greater injury compared with limited the equivalent. While this question previously addressed model, where occurs postnatally, it not yet an animal model all 3 equivalents occur prenatally, ovine. also correlate Purkinje cell loss alterations maternal arterial...
Intrauterine growth restriction (IUGR) is observed in conditions with limitations uterine space (e.g., anomalies and multifetal gestations). IUGR associated reduced fetal weight, organ growth, a spectrum of adult-onset diseases. To examine the interaction gestations, we developed surgical model unilateral horn ligation before breeding (unilateral surgery). Placentas fetuses were studied on Gestational Day (GD) 120 GD 130 (term = 147 days). Unilateral surgery decreased placentome numbers...
Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure causes fetal alcohol spectrum disorder (FASD) in children, but no study had tested this hypothesis using chronic model that mimicks common human pattern. Pregnant sheep were exposed to ethanol, 0.75 or 1.75 g kg(-1) (to create blood concentrations of 85 and 185 mg dl(-1), respectively), saline 3 days per week succession (a 'binge drinking' model) from gestational day (GD) 109 until GD 132. Fetuses...
Background Alcohol exposure during pregnancy results in an array of structural and functional abnormalities called fetal alcohol spectrum disorders (FASD). dysregulates the exquisite coordination regulation gestational adaptations at level uterine vasculature. We herein hypothesized that chronic binge-like vascular dysfunction impairs maternal artery reactivity to vasoconstrictors dilators. Methods utilized a once-daily binge (4.5 g/kg body weight) paradigm (gestational day 7 17) pregnant...