A5057857888- Fibromyalgia and Chronic Fatigue Syndrome Research
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Fibroblast Growth Factor Research
- Infrared Thermography in Medicine
- Occupational Health and Performance
- Nerve injury and regeneration
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Asthma and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Proteoglycans and glycosaminoglycans research
- Kruppel-like factors research
- Rheumatoid Arthritis Research and Therapies
- Lower Extremity Biomechanics and Pathologies
- Stress Responses and Cortisol
- Systemic Sclerosis and Related Diseases
- Sphingolipid Metabolism and Signaling
- Human Health and Disease
- Botulinum Toxin and Related Neurological Disorders
- Motivation and Self-Concept in Sports
- Adrenal Hormones and Disorders
The University of Texas at Austin
2020-2025
The Ohio State University
2008-2018
The Ohio State University Wexner Medical Center
2008-2018
Wake Forest University
2015
Capital University
2014
Duke University
2006
University of Connecticut
2006
Duke University Hospital
2006
Duke Medical Center
2006
Ohio University
2006
Fibromyalgia (FM) is a chronic muscle pain disorder that shares several clinical features with other related rheumatologic disorders. This study investigates the feasibility of using surface-enhanced Raman spectroscopy (SERS) gold nanoparticles (AuNPs) as fingerprinting approach to diagnose FM and rheumatic diseases such rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), osteoarthritis (OA), low back (CLBP). Blood samples were obtained on protein saver cards from (
This study examined gender differences in prospective within-day assessments of pain, pain coping, and mood men women having OA, analyzed dynamic relations between mood, coping. A sample 64 36 diagnosed as due to osteoarthritis the knee(s) rated their two times each day (once afternoon once evening) for 30 days using a booklet format. Two were found person-analyses: used more problem focused coping than men, who catastrophized less likely report negative mood. Several across-day noted....
Diagnosis and treatment of fibromyalgia (FM) remains a challenge owing to the lack reliable biomarkers. Our objective was develop rapid biomarker-based method for diagnosing FM by using vibrational spectroscopy differentiate patients with from those rheumatoid arthritis (RA), osteoarthritis (OA), or systemic lupus erythematosus (SLE) identify metabolites associated these differences. Blood samples were collected diagnosis (
Pain mechanisms in fibromyalgia syndrome (FMS) are not clearly understood. Growing evidence appears to suggest a role for small fiber polyneuropathy (SFPN) some FMS patients, as measured by epidermal nerve density (ENFD). We aimed better characterize and distinguish the subset of patients with both fiber, early or mild sensory (FM-SFSPN).155 neuropathic symptoms completed Short Form McGill Questionnaire visual analog scale addition having skin biopsies, conduction studies (NCS), serologic...
Fibromyalgia syndrome (FM), one of the most common illnesses that cause chronic widespread pain, continues to present significant diagnostic challenges. The objective this study was develop a rapid vibrational biomarker-based method for diagnosing fibromyalgia and related rheumatologic disorders (systemic lupus erythematosus (SLE), osteoarthritis (OA) rheumatoid arthritis (RA)) through portable FT-IR techniques. Bloodspot samples were collected from patients diagnosed with FM (n = 122) 70),...
The diagnostic criteria for fibromyalgia (FM) have relied heavily on subjective reports of experienced symptoms coupled with examination-based evidence diffuse tenderness due to the lack reliable biomarkers. Rheumatic disorders that are common causes chronic pain such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and low back frequently found be comorbid FM. As a result, this can make diagnosis FM more challenging. We aim develop classification algorithm using unique...
The present study examined relationships between pain coping, hormone replacement therapy, and laboratory clinical reports in post-menopausal women age-matched men with osteoarthritis. Assessment of nociceptive flexion reflex threshold was followed by an assessment electrocutaneous tolerance. Participants rated their arthritis using the Arthritis Impact Measurement Scales. To assess participants completed measures emotion-focused problem-focused catastrophizing. Results indicated that were...
In our center, systemic lupus erythematosus nephritis is routinely treated with an oral cyclophosphamide (POCY) regimen. POCY easy to administer and less expensive than intravenous (IVCY) as it currently used in the United States; however, use of has declined favor IVCY. Our experience suggests that well tolerated consistently associated good long-term outcomes. Here we report this build a case for maintaining therapeutic option nephritis.This single-center, retrospective analysis outcome 46...
Post Acute Sequelae of SARS-CoV-2 infection (PASC or Long COVID) is characterized by lingering symptomatology post-initial COVID-19 illness that often debilitating. It seen in up to 30–40% individuals post-infection. Patients with COVID (LC) suffer from dysautonomia, malaise, fatigue, and pain, amongst a multitude other symptoms. Fibromyalgia (FM) chronic musculoskeletal pain disorder leads functional disability severe impairment quality life. LC FM share several clinical features, including...
Background and objectives: Patients who have systemic lupus erythematosus (SLE) manifest antiphospholipid antibodies (APA) are at increased risk for thrombosis; however, it is difficult to predict will clot. This study tested the hypothesis that peak D-dimer level measured routinely during follow-up identifies whether a hypercoagulable state developing and, therefore, patient thrombosis. Design, setting, participants, & measurements: One hundred consecutive patients had SLE with recurrent...
Knee osteoarthritis (OA) is a leading cause of functional disability among American adults. Obesity strong independent risk factor for OA. While research emphasizes the role obesity in OA-physical function relationship, extent to which weight status impacts salient physical, health, and pain measures older, knee OA patients not well delineated. The primary aim this study was assess differences mobility performance (stair climb 400-meter walk), mobility-related self-efficacy, symptoms...
The aim of this study was to investigate the ability a rapid biomarker-based method for diagnosis fibromyalgia syndrome (FM) using mid-infrared microspectroscopy (IRMS) differentiate patients with FM from those osteoarthritis (OA) and rheumatoid arthritis (RA), identify molecular species associated spectral patterns. Under IRB approval, blood samples were collected diagnosed (n = 14), RA 15), or OA 12). Samples prepared, placed onto highly reflective slide, spectra IRMS. Spectra analyzed...
The present study elucidates the molecular structure of a murine fibroblast growth factor 1 (FGF-1) promoter and describes its distribution in adult developing mouse brain. A cDNA clone coding for FGF-1 was isolated from brain library. Nucleotide sequence analysis revealed that contained, addition to protein region, an untranslated exon (FGF-1B) 34 base pairs upstream translation start codon ATG. corresponded sole transcript An RNase protection assay used map transcription site 1B promoter....
Treatment of septic shock is a persistent dilemma. The clinical use agents such as naloxone has resulted in variable success. Because the dosage and timing these are considered critical factors their efficacy, we investigated both naloxone. Thirteen consecutive patients with documented resistance to one-liter fluid challenge underwent invasive hemodynamic monitoring administration by initial bolus 0.03 mg/kg followed infusion at rate 0.2 mg/kg.h over one hour. During one-hour observation...