A5037495730- Pharmacogenetics and Drug Metabolism
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Genetics, Aging, and Longevity in Model Organisms
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
- Mitochondrial Function and Pathology
- Phytochemicals and Antioxidant Activities
- COVID-19 Clinical Research Studies
- Ginger and Zingiberaceae research
- Adipokines, Inflammation, and Metabolic Diseases
- Insect Utilization and Effects
- Natural Compounds in Disease Treatment
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds in Plants
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- Eicosanoids and Hypertension Pharmacology
- Phytochemical compounds biological activities
- Coenzyme Q10 studies and effects
- Mosquito-borne diseases and control
- Alcohol Consumption and Health Effects
- Probiotics and Fermented Foods
- Piperaceae Chemical and Biological Studies
University of Nottingham Malaysia Campus
2018-2025
Swinburne University of Technology Sarawak Campus
2024-2025
Dengue has become a global affliction despite continuous efforts to find cure for this age-old disease. Hopeful results dengue vaccine are far-fetched as the effectiveness tied previous virus (DENV) exposure and billions of dollars needed be invested development. Medicinal plants ideal alternatives combat DENV infection it long been utilized in traditional medicine besides showing virucidal properties. However, mechanism action by which plant compounds inhibits viral replication machinery...
Cathinone is the psychostimulatory major active ingredient of khat (Catha edulis Forsk) and are often co-abused with alcohols polydrugs. With increased consumption cathinones on a global scale, efforts should be channelled into understanding minimising excruciating effects possible khat-drug interactions. This study aimed to determine in vitro inhibitory cathinone CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2 CYP3A5 silico identification their type interactions residues involved....
Cathine is the stable form of cathinone, major active compound found in khat (
Abstract Objectives Khat, a natural amphetamine-like psychostimulant plant, are widely consumed globally. Concurrent intake of khat and xenobiotics may lead to herb-drug interactions adverse drug reactions (ADRs). This study is continuation our previous study, targeted evaluate the in vitro inhibitory effects ethanol extract (KEE) on human cytochrome (CYP) 1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, CYP3A5, major metabolizing enzymes. Methods In fluorescence enzyme assays were...
Background: Mangiferin has been identified as one of the major active constituents Aquilaria plants. It was reported to have several promising chemotherapeutic potentials. Our preliminary data suggested that plant water extracts inhibited cytochrome P450 (CYP) isoenzymes in vitro. Objective: This study aimed investigate modulatory effects mangiferin on six drug metabolizing CYP enzymes including CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP3A4, and CYP3A5. Methods: The enzyme activities were measured...
The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, inhibitory effects CYPs enzyme activity is widely recognised, but much remains unknown about its mode action. This study demonstrated that exposure to high doses KEE, sibutramine at 12.5, 1.8, 1.8 mg/ml showed the most visible reduction in pharyngeal pumping rate, respectively. C. elegans an anomalous dynamic rate upon these compounds overall, a reduced amount progeny. extended...