A5040365617- Chromosomal and Genetic Variations
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic diversity and population structure
- Animal Behavior and Reproduction
- Subterranean biodiversity and taxonomy
- Plant Disease Resistance and Genetics
- CRISPR and Genetic Engineering
- Ichthyology and Marine Biology
- Marine Ecology and Invasive Species
- Attention Deficit Hyperactivity Disorder
- Animal Genetics and Reproduction
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Autism Spectrum Disorder Research
- Parasite Biology and Host Interactions
- Genetics and Neurodevelopmental Disorders
Institut de Génomique Fonctionnelle de Lyon
2019-2023
École Normale Supérieure de Lyon
2019-2023
Université Claude Bernard Lyon 1
2019-2023
Centre National de la Recherche Scientifique
2019-2023
Neurocentre Magendie
2017
Inserm
2017
Abstract Lungfishes belong to lobe-fined fish (Sarcopterygii) that, in the Devonian period, ‘conquered’ land and ultimately gave rise all vertebrates, including humans 1–3 . Here we determine chromosome-quality genome of Australian lungfish ( Neoceratodus forsteri ), which is known have largest any animal. The vast size this genome, about 14× larger than that humans, attributable mostly huge intergenic regions introns with high repeat content (around 90%), components resemble those tetrapods...
Evolution sometimes proceeds by loss, especially when structures and genes become dispensable after an environmental shift relaxes functional constraints. Subterranean vertebrates are outstanding models to analyze this process, gene decay can serve as a readout. We sought understand some general principles on the extent tempo of involved in vision, circadian clock, pigmentation cavefishes. The analysis genomes two Cuban species belonging genus Lucifuga provided evidence for largest loss...
Abstract Background Exaggerated secondary sexual traits are widespread in nature and often evolve under strong directional selection. Although heavily studied from both theoretical empirical viewpoints, we have little understanding of how selection influences sex-biased gene regulation during the development exaggerated phenotypes, these changes reflected genomic architecture. This is primarily due to limited availability representative genomes associated tissue sex transcriptomes study...
Because of diverged adaptative phenotypes, fish species the genus Xiphophorus have contributed to a wide range research for century. Existing genome assemblies are not at chromosomal level and prone sequence gaps, thus hindering advancement intra- inter-species differences evolutionary, comparative, translational biomedical studies. Herein, we assembled high-quality chromosome-level three distantly related species, namely, X. maculatus, couchianus, hellerii Our overall goal is precisely...
Although genes with similar expression patterns are sometimes found in the same genomic regions, almost nothing is known about relative organization genomes of and transposable elements (TEs), which might influence each other at regulatory level. In this study, we used transcriptomic data from male female gonads Japanese medaka Oryzias latipes to define sexually biased TEs analyze their localization. We identified 20,588 expressed adult O. latipes. Around 39% these differentially between...
Abstract Transposable elements (TEs) are parasite DNA sequences that able to move and multiply along the chromosomes of all genomes. They can be controlled by host through targeting silencing epigenetic marks, which may affect chromatin structure neighboring sequences, including genes. In this study, we used transcriptomic epigenomic high-throughput data produced from ovarian samples several Drosophila melanogaster simulans wild-type strains, in order finely quantify influence TE insertions...
Harbinger elements are DNA transposons that widespread from plants to vertebrates but absent mammalian genomes. Among vertebrates, teleost fish the clade presenting not only largest number of species also highest diversity transposable elements, both quantitatively and qualitatively, making them a very attractive group investigate evolution mobile sequences. We studied distantly related ISL2EU in fish, focusing on representative compared spotted gar, coelacanth, elephant shark amphioxus....
Abstract Evolution sometimes proceeds by loss, especially when structures and genes become dispensable after an environmental shift relaxing functional constraints. Gene decay can serve as a read-out of this evolutionary process. Animals living in the dark are outstanding models, particular cavefishes hundreds species evolved independently during very different periods time absence light. Here, we sought to understand some general principals on extent tempo several gene sets cavefishes. The...
Abstract Exaggerated secondary sexual traits are widespread in nature and often evolve under strong directional selection. Although heavily studied from both theoretical empirical viewpoints, we have little understanding of how selection influences sex-biased gene regulation during the development sex-specific phenotypes, these changes reflected genomic architecture. This is primarily due to lack a representative genome transcriptomes study traits. Here present developmental transcriptomes,...
Abstract Transposable elements (TEs) are parasite DNA sequences that able to move and multiply along the chromosomes of all genomes. They can be controlled by host through targeting silencing epigenetic marks, which may affect chromatin structure neighboring sequences, including genes. In this study, we used transcriptomic epigenomic high-throughput data produced from ovarian samples several Drosophila melanogaster simulans wild-type strains, in order finely quantify influence TE insertions...
Malignant melanoma incidence is rising worldwide. Its treatment in an advanced state difficult, and the prognosis of this severe disease still very poor. One major source these difficulties high rate metastasis increased genomic instability leading to a mutation development resistance against therapeutic approaches. Here we investigate as one contribution activation transposable elements (TEs) within tumor. We used well-established medaka model RNA-sequencing differential expression TEs...