A5061309176- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
Centre National de la Recherche Scientifique
2021-2023
Université Claude Bernard Lyon 1
2021-2023
Laboratoire de Physique de l'ENS de Lyon
2022-2023
École Normale Supérieure de Lyon
2021-2023
Institut de Génomique Fonctionnelle de Lyon
2021-2022
In human and other metazoans, the determinants of replication origin location strength are still elusive. Origins licensed in G1 phase fired S cell cycle, respectively. It is debated which these two temporally separate steps determines efficiency. Experiments can independently profile mean timing (MRT) fork directionality (RFD) genome-wide. Such profiles contain information on multiple origins' properties speed. Due to possible inactivation by passive replication, however, observed intrinsic...
Harbinger elements are DNA transposons that widespread from plants to vertebrates but absent mammalian genomes. Among vertebrates, teleost fish the clade presenting not only largest number of species also highest diversity transposable elements, both quantitatively and qualitatively, making them a very attractive group investigate evolution mobile sequences. We studied distantly related ISL2EU in fish, focusing on representative compared spotted gar, coelacanth, elephant shark amphioxus....
The nucleosome is a major modulator of DNA accessibility to other cellular factors. Nucleosome positioning has critical importance in regulating cell processes such as transcription, replication, recombination or repair. sequence factor influencing the position nucleosomes on genomes. Different motifs can promote inhibit formation, thus DNA. Sequence-encoded having functional consequences then be selected counter-selected during evolution. We review interplay between evolution and first...
Abstract Elucidating the global and local rules that govern genome-wide nucleosome organisation chromatin architecture remains a critical challenge. Thermodynamic modelling based on DNA elastic properties predicts presence of sequence-encoded nucleosome-inhibiting energy barriers (NIEBs) along vertebrate genomes. They delineate in vivo nucleosome-depleted regions (NDRs) flanked by 2-3 well positioned nucleosomes. Here, we compared mouse NIEBs to NDRs observed at CTCF binding sites active...
Abstract In human and other metazoans, the determinants of replication origin location strength are still elusive. Origins licensed in G1 phase fired S cell cycle, respectively. It is debated which these two temporally separate steps determines efficiency. Experiments can independently profile mean timing (MRT) fork directionality (RFD) genome-wide. Such profiles contain information on multiple origins’ properties speed. Due to possible inactivation by passive replication, however, observed...