A5033958520- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Mosquito-borne diseases and control
- Migraine and Headache Studies
- Hate Speech and Cyberbullying Detection
- IL-33, ST2, and ILC Pathways
- Zoonotic diseases and public health
- Network Security and Intrusion Detection
- Antiplatelet Therapy and Cardiovascular Diseases
- Sports injuries and prevention
- Adrenal Hormones and Disorders
- Biocrusts and Microbial Ecology
- COVID-19 epidemiological studies
- Immune responses and vaccinations
- Spam and Phishing Detection
- Pharmacology and Obesity Treatment
Clinical Research Institute
2024
University of Wisconsin–Madison
1979-2022
Pulmonary and Critical Care Associates
2021
Virginia Commonwealth University
2018
University of Virginia
2018
Washington University in St. Louis
2017
Northwest Orthopaedic Specialists
2012
Louisiana State University Health Sciences Center Shreveport
2007
Istituti di Ricovero e Cura a Carattere Scientifico
2002
Valley Medical Center
1998
Epithelial cells are charged with protection at barrier sites, but whether this normally beneficial response might sometimes become dysfunctional still needs definition. Here, we recognized a pattern of imbalance marked by basal epithelial cell growth and differentiation that replaced normal airspaces in mouse model progressive postviral lung disease due to the Sendai virus. Single-cell lineage-tracing technologies identified distinct subset stem (basal ESCs) extended into gas-exchange...
SUMMARY Natural immunity may be involved in controlling viral spread hosts infected with HIV. A panel of γδ T cell receptor-positive lymphocyte clones was isolated from the peripheral blood healthy HIV− donors and tested for anti-HIV cytotoxic responses. Twelve 30 (40%) Vγ9+Vδ2+ clones, but none seven Vδ1+ displayed lytic activity against HIV-infected cells. The Vγ9+/Vδ2+ cells also lysed Daudi However, not all which targets had capacity to lyse Some were investigated potential proliferative...
Quadriceps rupture off the patella is traditionally repaired by a transosseous tunnel technique, although single-row suture anchor repair has recently been described. This study biomechanically tested new equivalent (TE) double-row technique compared with for quadriceps repair. After simulated quadriceps-patella avulsion in 10 matched cadaveric knees, repairs were completed either three (TT = 5) or TE (TE technique. Double-row done using two 5.5 Bio-Corkscrew FT (fully threaded) (Arthrex,...
Immunotherapy checkpoint inhibitors, such as antibodies targeting PD-1 and CTLA-4, have demonstrated the potential of harnessing immune system to treat cancer. However, despite encouraging results particularly with respect survival, only a minority patients benefit from these therapies. In clinical studies aimed at understanding changes in following immunotherapy treatment, ICOS (Inducible T cell CO-Stimulator) was shown be significantly up-regulated on CD4+ cells this associated activity,...
Summary: Crosses were made between strains of Dictyostelium discoideum involving two drug resistance markers and the mating-type locus. Over 6000 progeny from 263 individual germinated macrocysts four single-factor crosses, five two-factor crosses one three-factor cross characterized. In most cases a single macrocyst genotype, although in population any all possible parental recombinant genotypes recovered. There was no evidence linkage examined. No selection against carrying methanol or...
Automata Processing is an important kernel for many application domains, and challenging to accelerate using general purpose, von Neumann computers. New research into accelerators automata processing motivated the creation of ANMLZoo, a standardized benchmark suite that reflects modern use-cases processing. While researchers have adopted ANMLZoo as de-facto measure improvements in processing, certain drawbacks emerged after years use. In this work, we first examine opportunities improvement...
Meeting abstracts ICOS (inducible co-stimulator molecule) is a T cell encoded member of the extended B7/CD28 superfamily that up-regulated upon early activation. Previous studies have shown higher expression on circulating cells, post treatment with ipilimumab, associated
Voice assistants are deployed widely and provide useful functionality. However, recent work has shown that commercial systems like Amazon Alexa Google Home vulnerable to voice-based confusion attacks exploit design issues. We propose a systems-oriented defense against this class of demonstrate its functionality for Alexa. ensure only the skills user intends execute in response voice commands. Our key insight is we can interpret user's intentions by analyzing their activity on counterpart web...
Abstract We studied the potential of combining insect immune priming to synergize with introduction diverse migrant safeguard small populations from disease outbreaks that might otherwise lead extinction. Immune in insects refers stronger response have against pathogens after prior exposure. This enhanced immunity can be passed on offspring and holds promise for conservation efforts diseases. compared fitness benefits a small, inbred population adding migrants had not been primed migrants....
SUMMARY A continuous-passage horse leukocyte culture was susceptible to the virus of equine infectious anemia ( eia ) as determined by cytopathic effect cpe and viral titer. Ultrafiltration studies indicated that less than 32 mμ in diameter which agrees with previous reports. Susceptible horses had clinical signs pathologic lesions compatible those when they were inoculated both unfiltered ultrafiltered grown cultures.
Abstract ICOS (the inducible T-cell co-stimulator) is a co-stimulatory molecule expressed on the surface of T cells and member CD28 family, which includes clinically validated targets cancer immunotherapies, such as PD-1 CTLA-4. Clinical data identified potentially key in providing optimal antitumor benefit following anti-CTLA-4 therapy. We have developed species cross-reactive humanized IgG1 agonist antibody, JTX-2011, that binds designed to induce an immune response. Our preclinical...
Abstract ICOS (inducible co-stimulator molecule) is a co-stimulatory molecule and member of the CD28 superfamily expressed primarily on T lymphocytes. Analysis cancer patient samples as well rodent preclinical data have implicated role for pathway in immunotherapy. We generated panel anti-ICOS monoclonal antibodies with vitro agonistic properties. The are efficacious monotherapies combination anti-PD1 multiple syngeneic tumor models. Mechanistic studies demonstrate that regression associated...