A5022524882- Rheumatoid Arthritis Research and Therapies
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Eosinophilic Disorders and Syndromes
- Patient-Provider Communication in Healthcare
- Palliative Care and End-of-Life Issues
- Nanoparticle-Based Drug Delivery
- Autoimmune and Inflammatory Disorders Research
- Graphene and Nanomaterials Applications
- Drug-Induced Adverse Reactions
- Colorectal and Anal Carcinomas
- Cancer, Stress, Anesthesia, and Immune Response
- Celiac Disease Research and Management
- PARP inhibition in cancer therapy
- Blood disorders and treatments
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
Western University
2011-2021
Chongqing Cancer Hospital
2021
Chongqing University
2021
Cygnal Therapeutics (United States)
2019
University of Toronto
2007-2017
University of Ottawa
2017
London Health Sciences Centre
2017
Sunnybrook Health Science Centre
2013
Health Sciences Centre
2013
Canadian Rheumatology Association
2013
Abstract Background Neonatal blood, obtained from a heel stick and stored dry on paper cards, has been the standard for birth defects screening 50 years. Such dried blood samples are used, primarily, analysis of small-molecule analytes. More recently, DNA complement such cards used targeted genetic testing, as single nucleotide polymorphism in cystic fibrosis. Expansion testing to include polygenic traits, perhaps whole genome scanning, discussed formal possibility. However, until now amount...
Systemic sclerosis (SSc) is a multisystem disease with heterogeneity in presentation and prognosis.An international collaboration to develop new SSc subset criteria underway. Our objectives were identify systems of classification synthesize novel concepts inform development criteria.Medline, Cochrane MEDLINE, the Cumulative Index Nursing Allied Health Literature, EMBASE, Web Science searched from their inceptions December 2019 for studies related subclassification, limited humans without...
Objective. Anticitrullinated protein antibody (ACPA) is as sensitive as, but more specific than, rheumatoid factor (RF) and detected earlier in arthritis (RA). Although part of the RA classification criteria, ACPA testing not routinely paid for/accessible all jurisdictions. The effect missing was studied to determine whether failure perform could cause a care gap early inflammatory arthritis. Methods. Nearly 2000 patients (n = 1998) recruited an cohort were allocated into 3 groups: (1)...
Rapidly destructive coxarthrosis (RDC) is a rare syndrome that involves aggressive hip joint destruction within 6-12 months of symptom onset with no single diagnostic laboratory, pathological, or radiographic finding. We report an original case RDC as initial presentation seronegative rheumatoid arthritis (RA) in 57-year-old Caucasian woman presenting 6 progressive right groin pain and preceding trauma chronic steroid use. Over 5 months, she was unable to ambulate plain films showed complete...
Glycophorin C (GPC) is necessary in the maintenance of red blood cell structure. Severe autoimmune hemolytic anemia and disease fetus newborn (HDFN) have been associated with Gerbich (Ge) group system antigens expressed on GPC. Previous vitro studies cord progenitor cells shown that anti-Ge suppresses erythropoiesis.Here, we evaluated K562 erythroleukemic line to study cellular effects a murine anti-GPC. Cell proliferation was after treatment Flow cytometry used evaluate exofacial...
Abstract ICOS (the inducible T-cell co-stimulator) is a co-stimulatory molecule expressed on the surface of T cells and member CD28 family, which includes clinically validated targets cancer immunotherapies, such as PD-1 CTLA-4. Clinical data identified potentially key in providing optimal antitumor benefit following anti-CTLA-4 therapy. We have developed species cross-reactive humanized IgG1 agonist antibody, JTX-2011, that binds designed to induce an immune response. Our preclinical...
Abstract ICOS (inducible co-stimulator molecule) is a T cell encoded member of the extended B7/CD28 superfamily that up-regulated upon early activation. Previous studies have shown higher expression on circulating cells, post treatment with ipilimumab, associated better clinical outcome. In complementary pre-clinical studies, efficacy observed whole vaccine consisting ICOS-L expressing B16 melanoma (IVAX) suggests agonism this pathway could provide therapeutic benefit in cancer setting....
We describe a case of vancomycin-induced linear IgA bullous dermatosis (LABD) with unusual features in 75-year old woman who received intravenous vancomycin for methicillin-resistant Staphylococcus Aureus infection. Our patient demonstrated an lesional distribution initial facial involvement and longer latent period than usual, which to our knowledge has not yet been reported the literature. A skin punch biopsy including direct immunofluorescence study (IMF) confirmed diagnosis LABD. The...
<h3>Background</h3> Anti-citrullinated protein antibody (ACPA) is a serum biomarker that as sensitive as, but more specific than the rheumatoid factor (RF) and detected earlier in RA [1,2]. Although ACPAs are part of ACR classification criteria, ACPA testing not routinely paid for/accessible all jurisdictions. <h3>Objectives</h3> The impact missing early inflammatory arthritis patients was studied to determine if failure perform could cause gap care. <h3>Methods</h3> 2191 recruited CATCH...
11602 Background: ICOS (Inducible T cell CO-Stimulator) is a co-stimulatory molecule expressed primarily on lymphocytes. Clinical and preclinical data suggest that mediates anti-CTLA-4 driven anti-tumor responses. JTX-2011 an agonist antibody in clinical development advanced solid tumors (ICONIC trial). designed to generate immune response via stimulation of effector cells preferential reduction intra-tumoral regulatory cells. Single agent efficacy correlates with the percentage...
Abstract Peripheral nerves were first described as a component of tumors in the late 19th century. In mid-20th century early preclinical studies indicated that tumor cells could recruit innervation from spinal cord ganglia and stress promotes tumorigenesis. Within last 10 years improvements technologies allowing neuronal tracking regulation function have uncovered role for both autonomic sensory multiple types. Initial implicated this biology prostate, pancreatic, gastric breast cancer...
<h3>Objectives</h3> The aim of this study (CQGOG 0101) is to evaluate the safety and activity Niraparib (an oral PARP1/2 inhibitor) combined with brivanib in patients recurrent, metastatic, or persistent cervical cancer. <h3>Methods</h3> CQGOG0101 an open-label, single-arm, single-center, phase 2 trial. <h3>Results</h3> Between May 8th, 2020 Jan 22nd, 2021, 9 (median age, 50 years old [28–73]) were enrolled. Patients had received a median two (1–3) previous lines platinum-based therapy. All...