Joseph Gracé

ORCID: 0000-0002-9802-6692
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About
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Research Areas
  • Surgical Sutures and Adhesives
  • Pain Mechanisms and Treatments
  • Cannabis and Cannabinoid Research
  • Diagnosis and Treatment of Venous Diseases
  • Venous Thromboembolism Diagnosis and Management
  • Hemostasis and retained surgical items
  • Neuroscience and Neuropharmacology Research
  • Respiratory Support and Mechanisms
  • Renal and Vascular Pathologies
  • COVID-19 Clinical Research Studies
  • Sepsis Diagnosis and Treatment
  • COVID-19 and healthcare impacts
  • Intensive Care Unit Cognitive Disorders
  • Pharmacological Effects and Toxicity Studies
  • Facial Rejuvenation and Surgery Techniques
  • Systemic Sclerosis and Related Diseases
  • Long-Term Effects of COVID-19
  • Reconstructive Surgery and Microvascular Techniques
  • Vascular Malformations and Hemangiomas

St Vincent's Clinic
2021-2024

UNSW Sydney
2021-2024

St Vincent's Hospital
2023

St Vincent's Hospital Sydney
2021-2023

St Vincents Institute of Medical Research
2021

Louisiana State University Health Sciences Center New Orleans
2018-2020

Objective The aim was to retrieve and analyse the serious adverse events of venous occlusion systems used in cyanoacrylate adhesive closure (CAC) submitted regulatory agencies. Methods Total Product Life Cycle (TPLC) database US Food Drug Administration (FDA), Database Adverse Event Notifications (DAEN) Australian Therapeutic Goods (TGA), Yellow Card UK Medicines Healthcare Products Regulatory Agency (MHRA) were reviewed. Three Freedom Information (FOI) requests had be MHRA obtain data....

10.1177/02683555231211086 article EN Phlebology The Journal of Venous Disease 2023-10-30

BackgroundCharacteristics of critically ill adults with coronavirus disease 2019 (COVID-19) in an academic safety net hospital and the effect evidence-based practices these patients are unknown.Research QuestionWhat outcomes COVID-19 admitted to a network hospitals New Orleans, Louisiana, what is protocol for care associated improved outcomes?Study Design MethodsIn this multi-center, retrospective, observational cohort study ICUs four we collected data on ICU tested severe acute respiratory...

10.1016/j.chest.2020.08.2114 article EN other-oa CHEST Journal 2020-09-14

Cannabinoids can enhance the antinociceptive effects of opioids in a synergistic manner, potentially reducing analgesic dosage and improving pain therapy. This strategy has also been used as rationale to combine certain antidepressants opioids. In this experiment, opioid-induced thermal antinociception was assessed rhesus macaques using warm-water tail-withdrawal procedure with 3 water temperatures (40, 50, 55 °C). general, acute intramuscular (i.m.) cumulative doses heroin were studied...

10.1037/pha0000313 article EN Experimental and Clinical Psychopharmacology 2019-08-29

Objectives The objective is to investigate the interaction of sclero-embolic and contrast agents with polymerisation medical grade n-butyl-cyanoacrylates. Methods An in vitro spectrophotometric absorbance method was developed detect changes light transmission measure n-BCA polymerisation. initiation rate-of-polymerisation mixtures were investigated. Results Initiation polymerisation: VENABLOCK™ HISTOACRYL® fastest polymerise, while VENASEAL™ slowest. Rate Hypertonic saline inhibited all...

10.1177/02683555231214343 article EN Phlebology The Journal of Venous Disease 2023-11-09

Opioid analgesics can provide adequate pain relief under some conditions; however, adverse effects such as dependence, abuse liability, and respiratory depression are major clinical complaints. Cannabinoids THC (the psychoactive constituent in marijuana) produce analgesic conditions, but generally at higher doses that behaviorally disruptive effects. Combinations of opioids thermal antinociceptive a synergistic manner, ineffective each drug antinociception when given combination. In this...

10.1096/fasebj.2018.32.1_supplement.684.1 article EN The FASEB Journal 2018-04-01

Cannabinoid administration prior to opioid can produce opioid‐sparing antinociceptive effects in several species by reducing the dosage of needed effective antinociception. These potentially valuable clinical could be undermined, however, if cannabinoids also enhance disruptive opioids on neurobehavioral function. To address this question, combined THC and heroin were examined nonhuman primates (rhesus macaques, n=4) responding a learning performance task concurrently exposed tail‐withdrawal...

10.1096/fasebj.2019.33.1_supplement.808.13 article EN The FASEB Journal 2019-04-01

Contrast agents are used widely in the interventional setting and particularly management of vascular anomalies have also been combination with sclero-embolic agents. There is limited information on interaction contrast sclerosant when as mixtures. The aim this study was to determine effect mixing radiological detergent sclerosants measuring change lytic activity vitro by proxy potency.Red blood cell lysis assessed following incubation two commonly agents, LIPIODOL® ULTRAVIST®, mixed...

10.1177/02683555211018312 article EN Phlebology The Journal of Venous Disease 2021-05-27
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