A5057205178- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Blood properties and coagulation
- Dermatologic Treatments and Research
- Head and Neck Surgical Oncology
- Surgical Sutures and Adhesives
- Cerebrospinal fluid and hydrocephalus
- Systemic Sclerosis and Related Diseases
- Heart Failure Treatment and Management
- Central Venous Catheters and Hemodialysis
- Cell Adhesion Molecules Research
- Blood groups and transfusion
- Peripheral Artery Disease Management
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Dysraphism and Malformations
- Cardiac Structural Anomalies and Repair
- Genetic Neurodegenerative Diseases
- Atrial Fibrillation Management and Outcomes
- Pituitary Gland Disorders and Treatments
- History of Medicine Studies
- S100 Proteins and Annexins
- 14-3-3 protein interactions
St Vincent's Hospital Sydney
2013-2024
St Vincent's Clinic
2016-2024
UNSW Sydney
2014-2024
St Vincent's Hospital
2007-2024
St Vincents Institute of Medical Research
2012-2024
Australasian College of Dermatologists
2021
Louisiana State University Health Sciences Center Shreveport
2012-2016
Derriford Hospital
2016
The University of Sydney
2000-2014
Louisiana State University
2012-2014
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for was identified as unstable expansion of CAG repeats in gene encoding huntingtin protein 1993, numerous mouse models HD have been generated to study pathogenesis evaluate potential therapeutic approaches. Of these, knock-in best mimic human condition from a genetic perspective since they express appropriate context....
It has been widely accepted that microparticles expose phosphatidylserine which in turn binds annexin V. was the objective of this study to compare antigenic characteristics and phospholipid-dependent procoagulant activity V positive -negative subpopulations platelet-derived microparticles. Annexin were identified characterised using flow cytometry measured by a assay (XACT). In unstimulated platelet-poor plasma, 80% failed bind Varying constituents (buffer, calcium concentration) did not...
Essentials Platelet extracellular vesicles (EVs) concentrations measured by flow cytometers are incomparable. A model is applied to convert ambiguous scatter units EV diameter in nanometer. Most included lack the sensitivity detect EVs of 600 nm and smaller. The outperforms polystyrene beads for comparability platelet concentrations.Background Detection cytometry has poor interlaboratory comparability, owing differences cytometer (FCM) sensitivity. Previous workshops distributed set a...
Object Complications following lumboperitoneal (LP) shunting have been reported in 18% to 85% of cases. The need for multiple revision surgeries, development iatrogenic Chiari malformation, and frequent wound complications prompted many abandon this procedure altogether the treatment idiopathic benign intracranial hypertension (pseudotumor cerebri), favor ventriculoperitoneal (VP) shunting. A direct comparison complication rates health care charges between first-choice LP versus VP is...
Objective The aim was to retrieve and analyse the serious adverse events of venous occlusion systems used in cyanoacrylate adhesive closure (CAC) submitted regulatory agencies. Methods Total Product Life Cycle (TPLC) database US Food Drug Administration (FDA), Database Adverse Event Notifications (DAEN) Australian Therapeutic Goods (TGA), Yellow Card UK Medicines Healthcare Products Regulatory Agency (MHRA) were reviewed. Three Freedom Information (FOI) requests had be MHRA obtain data....
Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe prothrombotic complication of adenoviral vaccines, including the ChAdOx1 nCoV-19 (Vaxzevria) vaccine. The putative mechanism involves formation pathological anti–platelet factor 4 (PF4) antibodies that activate platelets via low-affinity immunoglobulin G receptor FcγRIIa to drive thrombosis and thrombocytopenia. Functional assays are important for VITT diagnosis, as not all detectable anti-PF4 pathogenic,...
One of the mechanisms by which platelet-derived microparticles elicit procoagulant activity is an increased exposure phosphatidylserine on their surface. We have previously demonstrated utility activated factor X-based assay for detection phospholipid [Xa clotting time (XACT)]. The objective this study was to further characterize specificity XACT detect microparticle-associated activity. testing measured using ST4 machine and microparticle counting performed flow cytometry Annexin V binding....
Essentials Procoagulant platelets can be detected using GSAO in human whole blood. Stable coronary artery disease is associated with a heightened procoagulant platelet response. Agonist-induced response not inhibited by aspirin alone. Collagen plus thrombin induced partially resistant to clopidogrel.Background are subset of highly activated critical role generation. Evaluation their clinical utility thrombotic disorders, such as (CAD), has been thwarted the lack sensitive and specific blood...
Huntington's disease (HD) is a progressive neurodegenerative marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep circadian function that can be observed HD patients mouse models, with abnormal patterns correlating symptom severity patients. Here, we studied the behavior of BAC model using an 24/7 automated system; results indicate significant lengthening period mutant mice. These reinforce previous models symptomatic patients, indicating...
Phenotyping with traditional behavioral assays constitutes a major bottleneck in the primary screening, characterization, and validation of genetic mouse models disease, leading to downstream delays drug discovery efforts. We present novel comprehensive one-stop approach phenotyping, PhenoCube™. This system simultaneously captures cognitive performance, motor activity, circadian patterns group-housed mice by use home-cage operant conditioning modules (IntelliCage) custom-built computer...
CLIC1 belongs to a family of highly conserved and widely expressed intracellular chloride ion channel proteins existing in both soluble membrane integrated forms. To study the physiological biological role vivo, we undertook conditional gene targeting engineer Clic1 knock-out mice. This represents creation first vertebrate CLIC protein member. We generated Knock-in (Clic1(FN)) allele, followed by (Clic1(-/-)) mice crossing Clic1(FN) allele with TNAP-cre mice, resulting germline deletion...