A5080733103- Vibrio bacteria research studies
- Immunodeficiency and Autoimmune Disorders
- Aquaculture disease management and microbiota
- Pneumonia and Respiratory Infections
- Oral health in cancer treatment
- Salmonella and Campylobacter epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Head and Neck Cancer Studies
- Phytochemistry and Bioactive Compounds
- Fungal Infections and Studies
- Antimicrobial Peptides and Activities
- NF-κB Signaling Pathways
- Otolaryngology and Infectious Diseases
- 14-3-3 protein interactions
- Respiratory viral infections research
- Sinusitis and nasal conditions
- Autoimmune and Inflammatory Disorders
- Cytokine Signaling Pathways and Interactions
- Lipid Membrane Structure and Behavior
- Galectins and Cancer Biology
- Bacterial biofilms and quorum sensing
- Cancer Diagnosis and Treatment
University of Toledo
2015-2022
University of Toledo Medical Center
2018-2020
Vibrio cholerae is a natural inhabitant of aquatic ecosystems worldwide, typically residing in coastal or brackish water. While more than 200 serogroups have been identified, only O1 and O139 associated with epidemic cholera. However, infections other cholera can be caused by nonepidemic, non-O1/non-O139 V. strains, including gastroenteritis extraintestinal infections. also survive freshwater, that observed regions the world where endemic. We recently isolated from several locations lakes...
Significance Blocking IL-17A signaling is an attractive therapy in treating autoimmune diseases. Current blockers target both branches, leading to inhibition of TRAF6-based IL-6 production, and TRAF5-based CXCL-1 production. Global suppression branches concern due the critical role plays host-defense mechanisms. Our study shows that 14-3-3ζ necessary for IL-17A–stimulated We also found represses TRAF5-mediated induction. Taken together, our results show a unique cross-talk between two via...
Oral mucositis (OM) is a treatment-limiting adverse side effect of radiation and chemotherapy. Approximately 80% patients undergoing radiotherapy (RT) for head neck cancers (HNC) develop OM, representing major unmet medical condition. Our understanding the immunopathogenesis OM limited, due in part to surprising paucity information regarding healing mechanisms oral mucosa. RNAseq tissue murine model that closely mimics human showed elevated expression IL-17 related immune pathways response...
The number of aging human immunodeficiency virus-infected (HIV+) individuals living in the United States has substantially grown over past two decades. Advanced age and HIV infection both increase susceptibility to Streptococcus pneumoniae due B cell dysfunction. combined impact these factors on pneumococcal vaccine responses remains unknown.We assessed serum immunoglobulin (Ig) G IgM levels opsonophagocytic killing assay (OPA) titers serotypes 14 23F HIV+ subjects HIV-uninfected (HIV-)...
Background Members of the Tumor Necrosis Factor (TNF)-superfamily have speculated roles in response against T-independent type II antigens (TI-II) including pneumococcal polysaccharides (PPS). Dysregulation their expression is associated with an enhanced risk for disease neonates but other high-risk populations HIV-positive individuals remains to be elucidated. Objective To investigate signals that contribute towards PPS-response and identify potential anomalies may account diminished...
Vibrio cholerae must sense and respond appropriately to stresses encountered in the aquatic environment human host. One stress both environments is exposure antimicrobial peptides (AMPs), produced as a part of innate immune response by all multicellular organisms. Previous transcriptomic analysis demonstrated that expression Stress-inducible protein A (SipA) (VCA0732), hypothetical protein, was highly induced AMP dependent on specific uncharacterized two-component system. In order better...
Fungal infections caused by Candida albicans are a serious problem for immunocompromised individuals, including those undergoing radiotherapy head and neck cancers. Targeted irradiation causes inflammatory dysregulation damage to the oral mucosa that can be exacerbated candidiasis. Post-irradiation cytokine interleukin-17 (IL-17) protects mucosae promoting epithelial regeneration balancing immune cell populations, which leads eventual healing of tissue. IL-17 signaling is also critical...
Abstract Vibrio cholerae is a natural inhabitant of aquatic ecosystems worldwide, typically residing in coastal or brackish water. While more than 200 serogroups have been identified, only O1 and O139 associated with epidemic cholera. However, infections other cholera can be caused by nonepidemic, non-O1/non-O139 V . strains, including gastroenteritis extraintestinal infections. also survive freshwater, that observed regions the world where endemic. We recently isolated from several...
Abstract Interleukin (IL)-17A is an important cytokine associated with autoimmune diseases and host defense. The mechanism of its action depends upon ability to induce pro-inflammatory cytokines, e.g., IL-6, IL-8 as well anti-fungal genes, b-defensin, CCL-20, CXCL-1. Most non-hematopoietic cells express IL-17 receptors respond IL-17A. Several regulators each the two independent arms IL-17A signaling- gene induction mRNA stabilization inflammatory are known; however, there limited knowledge...