Background: Diabetes mellitus (DM) includes metabolic disorders marked by chronic hyperglycemia. Vitamin D and its receptor (VDR) play crucial roles in DM pathophysiology. Four single nucleotide polymorphisms (SNPs) the VDR gene, namely FokI, TaqI, BsmI, ApaI, have been implicated risk. However, no prior meta-analysis has systematically assessed their associations across type 1 diabetes (T1DM), 2 (T2DM), gestational (GDM). Objectives: To investigate association of ApaI with susceptibility to...

Abstract Background: Adipokines are a group of cell signaling proteins produced by adipose tissue. These influence appetite, obesity, and insulin sensitivity, may interact with thyroid hormones. However, the exact relationship between hormones adipokines remains unclear. Objectives: The aim this study was to evaluate compare serum levels adipolin in healthy individuals hypothyroidism patients, including subclinical (SCH) overt (OH). Materials Methods: study’s case–control design involved 90...

Irisin is a myokine that has beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the of long-term moderate physical exercise irisin levels its correlations with body mass index (BMI), waist circumferences (WC), metabolic parameters in normal weight obese males. Material method. A follow-up case-control sixty male participants, comprised thirty obese, who had undergone supervised exercises for six months. Serum levels, fasting...

A new complexes of Ni(II), Pd(II), and Pt(II) have been synthesized from the reaction Azo-Schiff base ligand (L1) that was prepared by condensation firstly salicylaldehyde with ethylene diamine in a 1:2 molar ratio imine compound (S1) reacted 2,5-dichloro aniline, were employed preparation containing metal ions Pt(II). The structural characteristics compounds investigated using UV-Vis, IR NMR, conductance, elemental analysis, mass spectroscopy. results analysis point to 1:1 [M:L]...

Background: Schiff bases, especially Azo-Schiff are significant ligands in organic chemistry due to their coordination capabilities. They find applications various industrial sectors and biological studies. Metal complexes of particularly with tetradentate ligands, have gained attention for potential pharmacological benefits. However, there is limited information on the activities certain base complexes, such as 1H-indole-3-ethylenesalicyldamine derivatives. Method: The synthesis bis...

The aim of this study was to compare serum irisin, trace elements (Zn, Cu, Mg) levels between the group pregnant women with gestational diabetes mellitus (GDM) and healthy group.

The alterations of circulating adipocytokines have been reported in thyroid diseases or type 2 diabetes mellitus (T2DM), but such data T2DM coincident with clinical and subclinical thyroid-dysfunctions are limited, remain to be investigated. We studied the changes serum chemerin, resisitin visfatin patients dysfunctions, their association inflammatory insulin resistance-markers. A total 272 female male Iranian participants were selected divided into six groups: euthyroid group, T2DM, sub...

Morbid obesity is a serious health condition that can interfere with basic physical functions such as breathing or walking.Those who are morbidly obese at greater risk of illnesses including diabetes, high blood pressure, sleep apnea, gastro esophageal reflux disease, gallstones, osteoarthritis, heart and cancer.This study was designed by taking 60 patients 20 controls aged from 25 to 45 years morbid obesity.A collection samples done venous fasting the healthy volunteers after an overnight...

diabetes mellitus type 2 [T2DM] is associated with heightened inflammatory activity. The significance of markers in the context T2DM remains a subject debate. Interferon-λ1 (IFN-λ1), also referred to as interleukin-29 [IL-29], represents recent addition interferon family III. Primarily secreted by macrophages and developing dendritic cells. IL- 29 has crucial function various immune reactions. Minerals vitamins have important roles antioxidation anti-inflammation processes. main aims...

Through a meta-heuristic framework, this study examines various wastewater treatment methods in detail and proposes novel application of genetic algorithms (GAs) plant optimization. ASM models are adapted to include ion speciation pairing models, microplastics (MPs) challenged, indicating the need for further research. An integrated model accounts carbon, nitrogen, phosphorus, oxygen, hydrogen, emphasizing pH’s crucial role biological processes by examining microbial growth rates organic...

Research into alternative, green energy sources such as solar power has been driven by concerns about environmental sustainability, escalating petroleum costs, and surging demand. Solar can the entire world sustainably, since it is abundant easy to access. radiation, cell temperature, load impedance all play a part in improving efficiency of utilization. In order maximize utilization, Maximum Power Point Tracking (MPPT) techniques are used. address factors effectiveness, dynamic response,...

Colorectal cancer is a significant global health concern with high mortality rates. Silibinin compound derived from milk thistle anticancer properties and may be potential treatment option for colorectal cancer. Its poor solubility limits its clinical application, but various strategies, such as nanoparticle encapsulation, have shown promise. In this study, PEGylated niosomal drug delivery system was used to enhance the of silibinin, anti-proliferative effects were evaluated against human cell lines.

An organ with high metabolic activity, adipose tissue secretes a variety of adipocytokines that control the metabolism fats and carbohydrates advance insulin resistance (IR). It is currently unclear what pathophysiological mechanism underlies PCOS. In most cases, IR abnormalities coexist PCOS, chronic endocrine illness. Prompt identification intervention aid in enhancing patients' quality life while delaying development associated issues. Adipokine clusterin (encoded by CLU) new. Diabetes...

Abstract SARS-CoV-2, which mostly affects the respiratory system, is agent that causes COVID-19. The virus enters human cells through ACE2 receptor, expressed on surface of many different types in body. Once inside cell, begins to replicate and spread throughout Interferon Lambda-1, also known as IFN-λ1, a type cytokine secreted by immune system body response viral infections. Objective evaluate if serum levels Lambda-1 are associated with how severe COVID-19 infection is, so determine this...

Background & Objective: The most prevalent endocrine defect affecting women in their reproductive years is called polycystic ovarian syndrome (PCOS). It strongly correlated to metabolic syndrome, insulin resistance, and an increased risk of diabetes cardiovascular disease the future. heterodimer interleukin-39 (IL-39) 54 kDa. IL-12 family subunits p19 Ebi3 have been found create a novel complex known as IL-39 (p19/Ebi3), according researchers. This study aimed assess additional hormonal...

This study focused on the adsorption of albumin and creatinine surface zinc oxide nanoparticles. Factors affecting adsorption, like contact time, adsorbent dose, concentration, temperature, PH, shaking rate, were studied. The best conditions for found at 298k, pH = (7), concentration (2.25, 0.5x10-3)g/dL, (30, 2.5)min, weight NPs 10)mg both respectively. We that corresponds to Langmuir isotherms Temkin creatinin. Thermodynamic parameters determined (average ΔG -12563.57(J/mol.K), ΔH...

Background: Beta-thalassemia is among the most common groups of recessively inherited disorders worldwide hemoglobin production which produce by reduction or absence globin chain. Adropin a protein that plays an important role in metabolic and energy hemostasis insulin resistance. to examinate serum level adropin patients with β-thalassemia major evaluate correlation between resistance other clinical biomarkers. Materials Methods: hundred twenty sixty healthy control were involved present...

The development of multifunctional nanomaterials and devices for biomedical applications has garnered significant attention in recent years due to their potential revolutionize healthcare. In this study, we report the synthesis characterization novel with tailored properties targeted drug delivery, imaging, biosensing applications. We employed a bottom-up approach design fabricate nanocomposites comprising biocompatible polymers, metallic nanoparticles, quantum dots, which exhibit unique...

In conclusion, the analysis and measurement of thermal properties are crucial for a wide range applications in science, technology, industry. For energy efficiency optimisation, design sophisticated materials, creation cutting-edge technologies, it is essential to comprehend how heat transmitted handled within materials. Researchers can precisely evaluate conductivity, capacity, other parameters using variety experimental methodologies, including both conventional technologies. This enables...

Background. Diabetes mellitus is the metabolic ailment related to a hyperglycemia state caused by dysfunction of insulin secretion and action (IR). DM may exist with many symptoms like polyuria, Blurry vision, thirst, body weight loss. Sexual yeast infections frequently happen. causes injury organs kidneys, heart, eyes, nerves, blood vessels, etc.Methods. A case-healthy control study divided into three groups (30 newly diagnosed diabetes patients (male=20, female=10)) (male=22, female=18)...

Gestational Diabetes Mellitus (GDM) is one of the most common metabolic disorders pregnancy.This disease characterized by an abnormal glucose tolerance recognized for first time during pregnancy due to a decreased insulin sensitivity combined with insufficient secretion.To estimate preptin concentrations in pregnant gestational diabetes mellitus comparison healthy pregnant.A total 45 were divided into women mellitus(n=30) and (n=15)with age-matched serum levels biomarkers cytokine measured...

Abstract- The objective of this project was investigating and comparing changes serum irisin, trace levels the elements (Zn, Cu, Mg) in pregnant women with gestational diabetes mellitus GDM addition to wholesome group, examining correlation among irisin insulin impedance women. Sixty thirty were examined. pair groups matched for age, maternal irisin. Insulin age calculated by assay enzyme-linked immune sorbent kit at gestation 24-28 weeks. confederation between clinical biochemical...