A5015291997- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Apelin-related biomedical research
- Colorectal Cancer Surgical Treatments
- Radiopharmaceutical Chemistry and Applications
- Management of metastatic bone disease
- Cutaneous Melanoma Detection and Management
- Growth Hormone and Insulin-like Growth Factors
- Neurological Disorders and Treatments
- Hernia repair and management
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Ophthalmology and Eye Disorders
- Melanoma and MAPK Pathways
- Enhanced Recovery After Surgery
- Cancer, Stress, Anesthesia, and Immune Response
- Facial Nerve Paralysis Treatment and Research
University Hospital Southampton NHS Foundation Trust
2021-2023
Royal Marsden NHS Foundation Trust
2012-2018
Clatterbridge Cancer Centre NHS Foundation Trust
2018
Azienda Ospedaliera Sant'Andrea
2010-2015
Royal Marsden Hospital
2013
Sapienza University of Rome
2011
to investigate the factors affecting survival and toxicity in patients treated with stereotactic radiosurgery (SRS), special attention volumes of brain receiving a specific dose (V10 - V16 Gy) as predictors for radionecrosis.Two hundred six consecutive 310 cerebral metastases less than 3.5 cm were SRS primary treatment followed prospectively at University Rome La Sapienza Sant'Andrea Hospital. Overall survival, control, local control estimated using Kaplan-Meier method calculated from time...
To assess the accuracy of fractionated stereotactic radiotherapy (FSRT) using a mask fixation system.Sixteen patients treated with FSRT were involved in study. A commercial system (BrainLAB AG) was used for patient immobilization. Serial CT scans obtained before and during to immobilization by comparing isocenter position. Daily portal imaging acquired establish day position variation. Displacement errors along different directions calculated as combination systematic random errors.The mean...
To assess the accuracy of patient repositioning and clinical outcomes frameless stereotactic radiosurgery (SRS) for brain metastases using a mask fixation system.One hundred two patients treated consecutively with SRS as primary treatment at University Rome Sapienza Sant'Andrea Hospital between October 2008 April 2010 followed prospectively were involved in study. A commercial system (BrainLab) was used immobilization. computerized tomography (CT) scan obtained immediately before to evaluate...
to assess the safety and efficacy of fractionated stereotactic radiotherapy (FSRT) for large skull base meningiomas. Fifty-two patients with meningiomas aged 34-74 years (median age 56 years) were treated FSRT between June 2004 August 2009. All received residual or progressive more than 4 centimeters in greatest dimension. The median GTV was 35.4 cm3 (range 24.1-94.9 cm3), PTV 47.6 33.5-142.7 cm3). Treatment volumes achieved 5-8 noncoplanar beams shaped using a micromultileaf collimator...
To analyze the tumor control, survival outcomes, and toxicity after stereotactic radiosurgery (SRS) for skull base metastases from systemic cancer involving anterior visual pathway.We have analyzed 34 patients (23 females 11 males, median age 59 years) who underwent multi-fraction SRS a metastasis compressing or in close proximity of optic nerves chiasm. All were treated with frameless LINAC-based 5 daily fractions Gy each. Local distant failure, overall estimated using Kaplan-Meier method...
The literature contains conflicting reports on the value of low insulin-like growth factor 1 (IGF-1) levels in predicting radiation-induced hormone (GH) deficiency (GHD) childhood cancer survivors (CCS). These often involve small samples patients who have received irradiation or mixed cohorts including non-irradiated subjects.We undertook an analysis predictive IGF-1 CCS at risk for GHD after cranial radiotherapy involving hypothalamic-pituitary (HP) area a large single-centre cohort.We...
OBJECTIVES: SRS for brain metastases is an effective treatment with a reported survival of 7-14 months. Local control in the range 70-90% at 12 months, proportion patients who recurs locally we have evaluate efficacy repeat stereotactic radiosurgery (SRS) as salvage recurrent metastases. PATIENTS AND METHODS: Between May 2008 and December 2012, twenty-seven received metastasis University Rome Sapienza, Sant'Andrea Hospital. All had Karnofsky Performance Score ≥ 60 were previously treated...
Abstract Aims Background: Temozolomide is an oral chemotherapy drug widely used in the treatment of glial tumours. This generally well tolerated however, immediate and delayed hypersensitivity reactions have been described, necessitating interruption that could significantly impact survival. Method Case description: We report a case 39-year-old young woman with WHO grade 2 IDH1mutant diffuse astrocytoma (MGMT promoter methylated) left temporal lobe. She had tumour resection 2012 followed by...
BACKGROUND: The base of the skull is a less common site metastases; however, they represent clinical challenge as growing lesions in such area that compress optic nerve, chiasm, and nerves involved extraocular movement have been associated with serious morbidity. We analyzed tumor control, survival outcomes, toxicity after stereotactic radiosurgery (SRS) for metastases from systemic cancer involving anterior visual pathway. PATIENTS AND METHODS: 34 patients (23 females 11 males, median age...
Abstract AIMS Retrospective review of SRT for vestibular schwannoma. University Hospital Southampton treat tumour vol umes max 2.5cm in diameter without brainstem compression with 21Gy/3#. This reviews the experience local control and toxicity profile our centre impact limiting dmax. METHOD analysis patients treated radiologically diagnosed schwannoma from 2019 to present. Patient notes, audiograms, imaging radiotherapy planning system were reviewed data collection. No removed due missing...
Abstract AIMS To assess overall survival in malignant melanoma with cranial metastases following stereotactic radio- surgery/radiotherapy (SRST). METHOD Patients metastatic who received SRST for their at the Wessex Neuro- Oncology Unit were evaluated between January 2017 and 2023. Subtype analysis based on BRAF mutation was also performed. Their (OS) plotted using Kaplan-Meier graph. RESULTS 121 patients identified. The mean age referral 62 years (range 30-90). 50 had a while 71 wild type....
Abstract Aims Since 2016, the University Hospital Southampton NHS Foundation Trust (UHSFT) has been commissioned by England to deliver SRST brain metastases. At UHSFT, all referrals are discussed at Wessex Neurosciences multidisciplinary team meeting. Referrals that satisfy criteria set (estimated prognosis greater than 6 months, absence or controlled extracranial disease potentially controllable with a Karnofsky Performance Status >70%) will be offered SRST. This retrospective study...