A5051627437- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Abdominal Surgery and Complications
- Celiac Disease Research and Management
- Dietetics, Nutrition, and Education
- Gastric Cancer Management and Outcomes
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Gastrointestinal disorders and treatments
- Acute Lymphoblastic Leukemia research
- Palliative Care and End-of-Life Issues
- Obesity and Health Practices
- Diet and metabolism studies
- Liver Diseases and Immunity
- Nonlinear Dynamics and Pattern Formation
- Interprofessional Education and Collaboration
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 and COVID-19 Research
- Axon Guidance and Neuronal Signaling
- Head and Neck Surgical Oncology
- Enhanced Recovery After Surgery
University Hospital Southampton NHS Foundation Trust
2018-2024
NIHR Southampton Biomedical Research Centre
2019
Royal Bournemouth Hospital
2013-2014
Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
2013
University of Birmingham
1969-1975
SUMMARY The standard projection methods of dendritic field analysis have revealed that density decays exponentially with increasing distance from the centre perikaryon and present ideas about connectivity are largely based on this theory. However, inherent in method a series errors which not hitherto been defined indicate much data obtained by technique may be an artefact itself. it is possible, given sample neurons, to extrapolate three‐dimensional array fields employing computer technique....
Aims Percutaneous endoscopic gastrostomy (PEG) is an established route for enteral nutrition. Although rare, buried bumper syndrome (BBS) remains important and challenging complication to manage. Gastric mucosal overgrowth over the internal results in obstruction of stoma impedes delivery nutritional feeds via PEG tube. Many different techniques treating BBS have been described, but these largely limited case reports or small series. This study aimed determine efficacy safety T-piece pull technique
Aims A rare complication following the removal of a percutaneous endoscopic gastrostomy (PEG) tube is formation gastocutaneous fistula (GF). Although number techniques have been described for managing GF, to date there very little data on efficacy over-the-scope clips in treating GF. In this study we aimed determine and safety clip treatment persistent
<h3>Introduction</h3> Treatments available for Ulcerative Colitis (UC) are limited in those who fail thiopurines. British society of gastroenterology guidelines suggest the use methotrexate (MTX) or colectomy this group as biologics not funded UC England Wales. Clinical treatments used our unit include low dose thiopurine and allopurinol co-therapy (LDTA) topical arsenic. We report experience patients have failed standard thiopurines their subsequent treatment clinical outcomes....
<h3>Introduction</h3> The importance of presence a nutrition support team (NST) and steering committee (NSC) were recognised in 1994 by BAPEN with the recommendation that all major UK hospitals should appoint NSC at least one NST. It was delivering excellent nutritional care within required co-ordination oversight NSC. NST's role to bring together multi-disciplinary could hospital staff provision therapy, especially enteral parenteral support, ward level. A NST contain doctor, nurse,...
This project aimed to evaluate the time taken for formal reporting of blood culture results, associated impact this on prescribing appropriate antibiotic therapy and defining period starvation while parenteral nutrition (PN) is withheld patients with catheter-related bloodstream
<h3>Introduction</h3> Buried bumper syndrome (BBS) represents a rare, but potentially serious complication in percutaneous endoscopic gastrostomy (PEG) tubes. In BBS there is growth of the gastric mucosa over inner PEG tube, affecting 0.–% Options for management include insertion jejunal extension, surgical or removal. Endoscopic removal most attractive option as it least invasive procedure to remove buried (BB). Several techniques have been described including dissection (ESD) overgrown...
<h3>Introduction</h3> The OVESCO over the scope clip (OTSC) has recently been described in treating upper gastrointestinal (UGI) haemorrhage Europe. aim of this study was to determine whether use OTSC associated with lower UGI re-bleeding rates and mortality UK. <h3>Methods</h3> Consecutive episodes treated were identified from a prospective database UK tertiary centre 2-year period. Treatment opted for patients high risk features or failed conventional therapy. Over same time period, within...
<h3>Introduction</h3> Patients on home parenteral nutrition (HPN) are recognised to be at high risk of metabolic bone disease (MBD). ESPEN guidelines recommend screening with annual DEXA (Dual-energy X-ray absorptiometry) scans for all patients HPN. The National Institute Health and Care Excellence states that should not routinely performed without prior assessment e.g. by Fracture Risk Assessment Tool (FRAX). FRAX is used pre-DEXA estimate the 10 year probability major osteoporotic or hip...
<h3>Introduction</h3> Intestinal failure associated liver disease (IFALD) refers to injury due intestinal (IF) and parenteral nutrition (PN). This presents as steatosis cholestasis which can lead fibrosis cirrhosis. ESPEN recommends that IFALD should be diagnosed by the presence of abnormal function tests (LFTs) with radiological and/or histological evidence abnormality. Non-invasive such FIB-4, ELF Fibroscan<sup>®</sup> are not validated in patients IFALD. We assessed diagnostic correlation...
<h3>Introduction</h3> In patients presenting with symptoms suggestive of IBD (abdominal pain and/or diarrhoea) in common ECCO guidelines colonoscopy is the first line test at our institution. practice magnetic resonance enterography (MRE) then performed those where there a continuing clinical suspicion small bowel Crohn’s disease. However who present to non-IBD physicians Computed tomography abdomen and pelvis contrast (CTAP) often investigation. this situation MRE commonly exclude disease...
<h3>Introduction</h3> Uncontrolled studies have reported methotrexate (MTX) to be efficacious in patients with Ulcerative Colitis (UC). British Society of Gastroenterology guidelines recommend MTX who are unresponsive or intolerant thiopurines. Biologics not available for UC because local funding restrictions. Our practise is only consider failed thiopurine therapy despite dose optimisation, including allopurinol co-therapy, achieve therapeutic 6-thioguanine (TGN) and normal...
<h3>Introduction</h3> Gastrocutaneous fistulae (GF) are a rare, but difficult to manage complication after percutaneous endoscopic gastrostomy (PEG) tube removal. In cases, refractory conventional medical management various approaches have been used for their treatment including; surgical closure, through the scope clipping and suturing with variable results. The over-the-scope-clip (OTSC) has an emerging role in closure of gastrointestinal wall defects, including persistent GF. aim this...