A5011373452- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- DNA Repair Mechanisms
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Bacterial Infections and Vaccines
- Extracellular vesicles in disease
- Fungal and yeast genetics research
- Pneumocystis jirovecii pneumonia detection and treatment
Université Paris Cité
2024
Institut Pasteur
2024
Jawaharlal Nehru Centre for Advanced Scientific Research
2015-2023
Histone H3 and its variants regulate gene expression but the latter are absent in most ascomycetous fungi. Here, we report identification of a variant histone H3, which have designated H3VCTG because exclusive presence CTG clade ascomycetes, including Candida albicans, human pathogen. C. albicans grows both as single yeast cells hyphal filaments planktonic mode growth. It also forms three-dimensional biofilm structure host well on catheter materials under suitable conditions. null...
The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that binding is most enriched at the centromeres C. albicans, but not Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- 750-fold increase chromosome loss. Thus, report previously unknown role segregation.
Abstract The CUG‐Ser1 clade‐specific histone H3 variant (H3V CTG ) has been reported to be a negative regulator of planktonic biofilm growth transition in Candida albicans . preferential binding H3V at the gene promoters makes chromatin repressive for mode growth. two evolutionarily conserved chaperone complexes involved incorporating are CAF‐1 and HIRA. In this study, we sought identify complex(es) loading We demonstrate that C. cells lacking either Cac1 or Cac2 subunit complex, exhibit...