A5101968377- Venomous Animal Envenomation and Studies
- Immunotherapy and Immune Responses
- Blood properties and coagulation
- Biochemical and Structural Characterization
- Virus-based gene therapy research
- CAR-T cell therapy research
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Chemokine receptors and signaling
- Erythrocyte Function and Pathophysiology
- Single-cell and spatial transcriptomics
- Herpesvirus Infections and Treatments
- Cellular transport and secretion
- Cell death mechanisms and regulation
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Neuroscience and Neural Engineering
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Mitochondrial Function and Pathology
Roswell Park Comprehensive Cancer Center
2018-2024
General Hospital of Guangzhou Military Command
2010
Sun Yat-sen University
2005-2008
Bacillus Calmette-Guérin (BCG) is commonly used in the immunotherapy of bladder cancer (BlCa) but its effectiveness limited to only a fraction patients. To identify factors that regulate response human BlCa tumor microenvironment (TME) BCG, we ex vivo whole-tissue explant model. The levels COX2 BCG-activated explants closely correlated with local production Treg- and MDSCS attractants suppressive factors, while baseline did not have predictive value. Accordingly, observed BCG induced high...
Abstract Presence of cytotoxic CD8+ T cells (CTL) in tumor microenvironments (TME) is critical for the effectiveness immune therapies and patients' outcome, whereas regulatory T(reg) promote cancer progression. Immune adjuvants, including double-stranded (ds)RNAs, which signal via Toll-like receptor-3 (TLR3) helicase (RIG-I/MDA5) pathways, all induce intratumoral production CTL-attractants, but also Treg attractants suppressive factors, raising question whether induction these opposing...
Gradients of soluble molecules coordinate cellular communication in a diverse range multicellular systems. Chemokine-driven chemotaxis is key orchestrator cell movement during organ development, immune response and cancer progression. Chemotaxis assays capable examining responses to different chemokines the context various extracellular matrices will be crucial characterize directed motion conditions which mimic whole tissue conditions. Here, microfluidic device can generate chemokine...
Abstract Less than 50% of patients with higher-risk myelodysplastic syndromes (MDS) show clinical response to standard-of-care hypomethylating (HMA) therapy. Significant enthusiasm existed for immunotherapy/HMA combinations these patients, but studies have failed deliver on the initial promise. We demonstrated that MDS a deficiency in antigen-presenting cells, called CD141Hi dendritic cells (DC). DC-deficient reduced HMAs, worse overall survival, and less cancer vaccination. hypothesized...
<title>Abstract</title> The aim of this study was to investigate the functional expression cystic fibrosis transmembrane conductance regulator (CFTR) with electrophysiological and molecular technique in rat oviduct epithelium. In whole-cell patch clamp, epithelial cells responded 100 μM 8-bromo-adenosine 3‘,5‘-cyclic monophosphate (8-Br-cAMP) a rise inward current Gap-free mode, which inhibited successively by 5 CFTR(inh)-172, CFTR specific inhibitor, 1 mM diphenylamine-2-carboxylate (DPC),...
Abstract Purpose of Study: Dendritic Cells (DC) maturing in the conditions acute/early versus late/chronic inflammation (such as alpha-type-1-polarized DCs [αDC1s] and “standard” nonpolarized DCs; sDCs) deliver differential “signal 3” to resting T cells, resulting their different induction effector functions tumor-specific CD8+ cells. Here, using single-cell mRNAseq (scRNAseq), a unique technology allowing for unbiased analysis gene expression (GEX), we evaluated GEX patterns cellular...