A5066774022- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Autophagy in Disease and Therapy
- Gold and Silver Nanoparticles Synthesis and Applications
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Polyamine Metabolism and Applications
- Phagocytosis and Immune Regulation
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Moringa oleifera research and applications
University of North Texas Health Science Center
2018-2025
University of North Texas
2017-2025
Reconstituted high-density lipoprotein nanoparticles (rHDL NPs) have been utilized as delivery vehicles to a variety of targets, including cancer cells. However, the modification rHDL NPs for targeting pro-tumoral tumor-associated macrophages (TAMs) remains largely unexplored. The presence mannose on can facilitate TAMs which highly express receptor at their surface. Here, we optimized and characterized mannose-coated loaded with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an...
To meet the current need for a tumor-selective, targeted therapy regimen associated with reduced toxicity, our laboratory has developed spontaneously assembled nanostructure that resembles high-density lipoproteins (HDLs). These myristoyl-5A (MYR-5A) nanotransporters are designed to safely transport lipophilic pharmaceuticals, including novel anthracycline drug (N-benzyladriamycin-14-valerate (AD198)). This formulation been found enhance therapeutic efficacy and toxicity of drugs in...
Cytotoxic activity has been reported for the xanthone α-mangostin (AMN) against Glioblastoma multiforme (GBM), an aggressive malignant brain cancer with a poor prognosis. Recognizing that AMN’s high degree of hydrophobicity is likely to limit its systemic administration, we formulated AMN using reconstituted high-density lipoprotein (rHDL) nanoparticles. The photophysical characteristics formulation, including fluorescence lifetime and steady-state anisotropy, indicated was successfully...
The primary focus of this review is lipoprotein-based drug carriers, more specifically, high-density lipoprotein (HDL) type nanoparticles (NPs). These nanostructures are discussed regarding their suitability for clinical applications, particularly cancer therapy. Poor solubility and insufficient capability to selectively target malignant tumors represent significant challenges facing many anticancer drugs. Nevertheless, we others have found that most, if not all, these difficulties, can be...
Cluster BG of the actinobacteriophage was formed upon discovery five novel bacteriophages isolated by enrichment from their host, Streptomyces griseus subsp. strain ATCC 10137. Four members this cluster (BabyGotBac, Maih, TP1605, and YDN12) share over 89% average nucleotide identity, while other (Xkcd426) has only 72% similarity to members.
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The targeting and conversion of the immunosuppressive (M2) tumor-associated macrophages (TAMs) to an immunostimulatory (M1) phenotype can induce tumor regression in advanced melanoma. We have previously characterized reported ability reconstituted high-density lipoprotein nanoparticles (rHDL NPs) functionalized with DSPE-PEG-mannose (DPM) deliver payload macrophages. Herein, we investigate modulation macrophage delivery mechanisms rHDL-DPM NPs RAW 264.7 murine exposed conditioned medium (CM)...
Phenotypic plasticity of macrophages allows them to assume different functional profiles as they are called upon respond biological events. For example, the M1 phenotype macrophage potentiates pro‐inflammatory and anti‐tumoral properties whereas M2 is associated with immuno‐regulatory, tissue repair pro‐tumoral properties. Tumor‐associated (TAMs) initially present behaviors via their “M1” phenotype. Under stimulation factors secreted by malignant tumor, TAMs progressively take on a role...
DMXAA is a drug agonist of the stimulator interferon genes (STING) receptor. As such, it capable modulating functional phenotype tumor‐associated macrophages (TAMs) that originate from infiltrating monocytes and tissue‐resident macrophages. TAMs can account for up to 50% tumor mass are recognized as major contributors tumorigenesis. The pro‐tumoral activity linked ability cancer cells other components microenvironment (TME) educate TAMs, inducing them take on tumor‐promoting (M2) phenotype....
Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in tumor microenvironment (TME). Their immunosuppressive phenotype (M2) promotes progression. The re-education TAMs TME to a pro-immune (M1) is considered enhance effectiveness anti-tumor response and leads regression. An effective therapeutic approach utilizing macrophage re-polarization will likely require selective delivery agents execute M2-to-M1 transformation. This strategy known avoid adverse immune-related...