A5061170098- Cardiomyopathy and Myosin Studies
- Immune Cell Function and Interaction
- Cardiovascular Effects of Exercise
- Immunotherapy and Immune Responses
- Dementia and Cognitive Impairment Research
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience and Neuropharmacology Research
- Geriatric Care and Nursing Homes
- interferon and immune responses
- Virus-based gene therapy research
- Diabetes and associated disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Muscle Physiology and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Photoreceptor and optogenetics research
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Ultrasound Imaging and Elastography
- Ion channel regulation and function
- Schizophrenia research and treatment
- Wnt/β-catenin signaling in development and cancer
Tokyo Medical University
2002-2024
Tokyo Medical University Hospital
2024
Nagaoka Red Cross Hospital
2022
Kitasato University
2003-2020
Kitasato Institute Hospital
2020
Tokyo Metropolitan University
2019
Toshiba (Japan)
2018
Nagoya University
2014-2017
Nippon Medical School
2005-2017
Tokyo University of Marine Science and Technology
2017
Hyperpolarization-activated cyclic nucleotide-gated channel 4 gene HCN4 is a pacemaker that plays key role in automaticity of sinus node the heart, and an mutation was reported patient with dysfunction. Expression heart is, however, not confined to cells but found other tissues, including conduction system. On hand, mutations another cardiac ion gene, SCN5A, also cause dysfunction as well arrhythmias, long QT syndrome, Brugada idiopathic ventricular fibrillation, progressive disturbance....
The major effector cells for cellular adaptive immunity are CD8(+) cytotoxic T lymphocytes (CTLs), which can recognize and kill virus-infected tumor cells. Although CTLs exhibit strong cytolytic activity against target in vitro, a number of studies have demonstrated that their function is often impaired within tumors. Nevertheless, regain ability after escaping from the environment, suggesting milieu created by tumors may affect CTLs. As patho-physiological situation present vivo has been...
Abnormalities in Z-disc proteins cause hypertrophic (HCM), dilated (DCM) and/or restrictive cardiomyopathy (RCM), but disease-causing mechanisms are not fully understood. Myopalladin (MYPN) is a protein expressed striated muscle and functions as structural, signaling gene expression regulating molecule response to stress. MYPN was genetically screened 900 patients with HCM, DCM RCM, were investigated using comparative immunohistochemical analysis of the patient myocardium neonatal rat...
Abstract We present a Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy technique that achieves broadband CARS measurements at an ultrahigh scan rate of more than 20,000 spectra/s – 20 times higher previous techniques. This is made possible by integration FT-CARS system and rapid-scanning retro-reflective optical path length scanner. To demonstrate the technique’s strength, we use it to perform transient mixing dynamics toluene benzene in fingerprint region...
Abstract Background: The aim of the present study was to investigate predictive factors quality life (QOL) in home caregivers patients with dementia. Methods: A total 118 (48 male, 70 female) were asked complete World Health Organization (WHO) Quality Life 26 (WHO/QOL‐26) questionnaire, Pines Burnout Measure (BM), and Beck Depression Inventory, second edition (BDI‐II). Patient demographics clinical data regarding cognitive impairment, neuropsychiatric symptoms, dementia severity obtained...
Summary Peripheral blood monocytes extravasate and differentiate into tissue macrophages to mediate effective local defence, but how tissue‐specific stimuli environments may influence their functions remains unknown. Here, we found that peripheral gained the ability produce granulocyte–macrophage colony‐stimulating factor (GM‐CSF) upon exposure breast milk differentiated CD1 + dendritic cells (DCs) in presence of exogenous interleukin‐4 (IL‐4) alone. This vitro observation appeared...
Abstract To examine the differences in depressive state and associated factors between informal professional caregivers, a cross‐sectional study was carried out 23 home‐based caregivers of demented patients, 24 working dementia ward psychiatric hospital, 31 controls. Measurements included severity (Clinical Dementia Rating Scale, Mini Mental State Examination, MMSE) levels depression (Beck Depression Inventory; BDI), care burden (Zarit Caregiver Burden Interview; ZBI) quality life (World...
Intravesical bacillus Calmette-Guerin (BCG) therapy is considered the most successful immunotherapy against solid tumors of human bladder carcinoma. To determine actual effector cells activated by intravesical BCG to inhibit growth carcinoma, T24 tumor cells, expressing very low levels class I MHC, were co-cultured with allogeneic peripheral blood mononuclear (PBMCs) live BCG. The proliferation was markedly inhibited when BCG-infected dendritic (DCs) added culture although addition either or...
The minimum inhibitory concentration (MIC) of acetic and propionic acid for resident bacteria on normal human skin, such as Propionibacterium acnes Staphylococcus epidermidis, was 25 mg/mL or more at any pH tested (pH 5.5–6.8). While the MIC these acids most transient markedly decreased by lowering media 5.5, mean value 6.25 less. oleic some strains Gram-positive Streptococcus, Micrococcus, Bacillus 100 μg/mL less all pH's tested. aureus resistant to this 6.8, but became sensitive...
The aetiology of chronic thromboembolic pulmonary hypertension (CTEPH) is largely unknown and may be heterogeneous, because there are several ethnic differences in the clinical characteristics CTEPH. Female predominance a higher ratio to acute thromboembolism have been reported Japan as compared with USA. Because such controlled by genetic factors, current study investigated HLA polymorphisms Japanese patients typing serological and/or DNA methods was performed (for HLA-A, B, DPB1, DRB1) 80...