A5020155800- Mesenchymal stem cell research
- Iron Metabolism and Disorders
- Pluripotent Stem Cells Research
- Circadian rhythm and melatonin
- Higher Education Practises and Engagement
- Biomedical Ethics and Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Trace Elements in Health
- Insect Resistance and Genetics
- Virtual Reality Applications and Impacts
- Higher Education Learning Practices
- Higher Education and Employability
- Hemoglobinopathies and Related Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Biomedical and Engineering Education
- Reflective Practices in Education
- Problem and Project Based Learning
- Metal complexes synthesis and properties
- Doctoral Education Challenges and Solutions
- Neurobiology and Insect Physiology Research
- Career Development and Diversity
- Interdisciplinary Research and Collaboration
- Insect Pest Control Strategies
- Epigenetics and DNA Methylation
- Online and Blended Learning
Northumbria University
2008-2024
Applied Sciences (United States)
2011
University of Edinburgh
2008
University of Leicester
2007
Although the use of embryonic stem cells in assisted repair musculoskeletal tissues holds promise, a direct comparison this cell source with adult marrow-derived has not been undertaken. Here we have compared osteogenic differentiation potential human (hESC) adult-derived vivo. hESC lines H7, H9, HEF-1 mesenchymal-like, telomerized H1 derivative, kidney epithelial line HEK293 (negative control), and mesenchymal (hMSC) were either used untreated or treated factors for 4 days prior to...
Iron is a key metal involved in several biological processes such as DNA replication and repair, cellular proliferation cell cycle regulation. Excess volumes of labile iron are toxic can lead to the production ROS (reactive oxygen species) via Fenton chemistry. Due this reactive nature, it contribute damage genomic instability. Therefore, excess pool associated with cancer, which has made crucial target for anticancer therapy by targeting iron. This be incorporated into essential enzymes...
The circadian mechanism appears remarkably conserved between Drosophila and mammals, with basic underlying negative positive feedback loops, cycling gene products, temporally regulated nuclear transport involving a few key proteins. One of these regulators is PERIOD, which in shows very similar temporal spatial regulation to TIMELESS. Surprisingly, we observe that the housefly, Musca domestica, PER does not cycle Western blots head extracts, contrast TIM protein. Furthermore,...
The pivot to blended learning in the post-COVID-19 higher education environment has led increased adoption of virtual online laboratories as a mechanism for ensuring that students attain outcomes. fostering knowledge acquisition and simulation practical skills required laboratory-based disciplines is well established. In this study, we used grounded theory with partners co-create interviews surveys. aim surveys was capture student experiences perceptions use simulations their studies. A...
Cancer cells require large amounts of iron to maintain their proliferation. Iron metabolism is considered a hallmark cancer, making valid target for anti-cancer approaches. The development novel compounds and the identification leads further modification requires that proof mechanism assays be carried out. There are many evaluate impact on proliferation; however, ability chelate an important sometimes overlooked end-point measure due high costs equipment challenge quickly reproducibly...
Cancer cells require large amounts of iron to maintain their proliferation. Iron metabolism is considered a hallmark cancer, making valid target for anti-cancer approaches. The development novel compounds and the identification leads further modification requires that proof mechanism assays be carried out. There are many evaluate impact on proliferation; however, ability chelate an important sometimes overlooked end-point measure due high costs equipment challenge quickly reproducibly...
Introduction: Developing research skills enhances graduate attributes and student employability. The UG project is coined the pedagogy of 21st century but diversity supervisory styles a source perceived inequality experience. goal this study was to provide structure support undergraduate (UG) biomedical science students supervisors by co-creating informed resources that are accessible, engaging centred. We asked 1) How do experience supervision? 2) What approaches use students? 3) as...
Anti-cancer therapy by iron chelation has been shown to inhibit many cellular processes including DNA replication, mitochondrial metabolism and oncogenic signalling pathways (e.g., EGFR). Iron chelator SK4 represents a double pronged approach towards treating cancer. enters through LAT1, commonly overexpressed amino acid transporter in tumours, thus targeting addiction LAT1 overexpression. The aim of this study was characterise the mode action proteomics, metabolomics, lipidomics seahorse...
An important final year assessment which is common to most UK Undergraduate (UG) degree programmes the project or dissertation.It considered capstone module on whereby students gain valuable skills valued by employers.Our engages UG in a collaboration designed with inclusivity and partnership mind.We ran student-led conferences communicate experience of disseminate their top tips level 5 students.The sits across three disciplines health life sciences, largest faculty Northumbria University...