A5107964328- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Wildlife-Road Interactions and Conservation
- Autophagy in Disease and Therapy
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Amphibian and Reptile Biology
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Energy and Environment Impacts
- Turtle Biology and Conservation
- Renal Transplantation Outcomes and Treatments
- Atherosclerosis and Cardiovascular Diseases
Vanderbilt University
2017-2020
Indiana University – Purdue University Indianapolis
2015-2016
Indiana University School of Medicine
2013-2015
University of Indianapolis
2015
Indiana University
2013
Resistance is not futile The fungal disease chytridiomycosis has wreaked havoc on amphibians worldwide. caused by the organism Batrachochytrium dendrobatidis and was first identified in late 1990s. Voyles et al. revisited protected areas Panama where catastrophic amphibian losses were recorded a decade ago (see Perspective Collins). Although theory predicts that epidemics should result reduced pathogenicity, they found no evidence for such reduction. Despite this, community displaying signs...
Abstract Cells use multiple autophagy pathways to sequester macromolecules, senescent organelles, and pathogens. Several conserved isoforms of the lysosome-associated membrane protein-2 (LAMP-2) regulate these influencing immune recognition responses. LAMP-2A is required for chaperone-mediated (CMA), which promotes Ag capture MHC class II (MHCII) presentation in B cells signaling T cells. LAMP-2B regulates lysosome maturation impact macroautophagy phagocytosis. Yet, far less known about...
Chronic granulomatous disease (CGD) is an inherited immunodeficiency linked with mutations in the multi-subunit leucocyte NADPH oxidase. Myeloid-derived phagocytic cells deficient oxidase fail to produce sufficient levels of reactive oxygen species clear engulfed pathogens. In this study we show that also influences B-cell functions, including responses single-stranded RNA or unmethylated DNA by endosomal Toll-like receptors (TLRs) 7 and 9. response TLR7/9 ligands, lines derived from...
Abstract B lymphocytes migrate among different micro-anatomic sites for diversification, selection, and eventual differentiation into antibody-secreting plasma cells. Emerging evidence supports the premise that aspects of nutrient milieu vary within lymphoid micro-environments. However, role cell-intrinsic metabolic programs in regulating cell antibody response quality remain unclear. We now show amino acid-sensing mTOR complex 1 (mTORC1) is essential induction Bcl6 IRF4, key transcriptional...
Abstract Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency linked with mutations in the multi-component leukocyte NADPH oxidase. Phagocytic cells deficient oxidase fail to produce sufficient levels of reactive oxygen species (ROS) necessary clear engulfed pathogens. Though hyperactive immune response associated CGD widely described phagocytes, effects oxidase-deficiency on B cell functions has not been well studied. In cells, recognition microbial single-stranded RNA or...
Abstract Emerging evidence indicates that metabolic programs regulate B cell activation and antibody responses. However, the mediators support durability of memory long-lived plasma populations are not fully elucidated. Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionary conserved serine/threonine integrates cellular energy status nutrient availability to intracellular signaling pathways. Here, we use genetic mouse models show restricted loss catalytic subunit, AMPKα1,...