A5028002395- Endoplasmic Reticulum Stress and Disease
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Vibrio bacteria research studies
- Photoreceptor and optogenetics research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Structure and Dynamics
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Immune cells in cancer
- Liver Disease and Transplantation
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Energy and Environment Impacts
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
- CRISPR and Genetic Engineering
- Bacillus and Francisella bacterial research
University of North Carolina at Chapel Hill
2020-2024
Sarah Cannon
2023
Lung Institute
2022
Waverly Hematology Oncology
2008
The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) supply nutrient stress, it is established that enriched FAO are adept at cancer control. However, endogenous TILs unmodified cellular therapy products fail sustain bioenergetics tumors. We reveal imposes...
The transmembrane Hsp40 DNAJB12 and cytosolic Hsp70 cooperate on the endoplasmic reticulum's (ER) cytoplasmic face to facilitate triage of nascent polytopic membrane proteins for folding versus degradation. N1303K is a common mutation that causes misfolding ion channel CFTR, but unlike F508del-CFTR, biogenic functional defects in N1303K-CFTR are resistant correction by modulators. reported arrest CFTR at late stage after partial assembly its N-terminal domains. intermediates clients...
P23H-rhodopsin accumulates in an ERAD-resistant conformation that is stabilized by DNAJB12 and Hsp70. FIP200 colocalize on the rim of omegasomes to which lysosomes dock during disposal dominantly toxic P23H-rhodopsin.
To evaluate overall survival (OS), progression-free (PFS) and toxicity after resin Yttrium-90 (Y-90) radioembolization in Barcelona Clinic Liver Cancer B (BCLC B) hepatocellular carcinoma (HCC) patients using the Bolondi subgroup classification.A total of 144 BCLC were treated between 2015-2020. Patients broken into 4 subgroups by tumor burden/liver function tests with 54, 59, 8 23 1, 2, 3 4. OS PFS calculated Kaplan-Meier analysis 95% confidence intervals. Toxicities assessed Common...
The endoplasmic reticulum (ER) fills the cell with a continuous network of sealed membrane tubules and sheets. ER is subdivided into microdomains mediating one-third total protein biosynthesis, oxidative folding, secretion, quality control, calcium signaling, marcoautophagy/autophagy, stress sensing, apoptosis. Defects in ER-calcium homeostasis underlie several diseases. Damage to by misfolded proteins suppressed specific HSPA/Hsp70 DNAJ/Hsp40 chaperone pairs that select intermediates for...
SUMMARY The transmembrane Hsp40 DNAJB12 and cytosolic Hsp70 cooperate on the ER’s cytoplasmic face to facilitate triage of nascent polytopic membrane proteins for folding versus degradation. N1303K is second most common mutation in ion channel CFTR, but unlike F508del-CFTR, biogenic functional defects N1303K-CFTR are resistant correction bolding modulators. reported arrest CFTR at a late stage after partial assembly its N-terminal domains. intermediates clients JB12-Hsp70 complexes,...
Abstract We report on how the ER-associated-autophagy pathway (ERAA) delivers P23H-rhodopsin (P23H-R) to lysosome. P23H-R accumulates in an ERAD-resistant conformation that is stabilized by DNAJB12 and Hsp70. P23H-R, DNAJB12, FIP200 co-localize discrete foci punctuate rim of omegasome rings coated WIPI1. tubules thread through wall WIPI1 into their central cavity. Transfer from ER-connected phagophores lysosomes requires GABARAP, associated with transient docking rings. Instances are...