A5058311217- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Cancer Research and Treatments
- Dietary Effects on Health
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Neonatal Respiratory Health Research
- Amino Acid Enzymes and Metabolism
- Cancer Immunotherapy and Biomarkers
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Mitochondrial Function and Pathology
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
University of North Carolina at Chapel Hill
2018-2025
Inspire Medical Systems (United States)
2017-2024
University of North Carolina Health Care
2019-2024
David H. Murdock Research Institute
2020-2024
University College Cork
2018
University of Birmingham
2016
Vanderbilt University Medical Center
2001
Children’s Minnesota - St. Paul Hospital
1980-1987
University of Minnesota
1981-1987
Georgetown University Medical Center
1978
The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) supply nutrient stress, it is established that enriched FAO are adept at cancer control. However, endogenous TILs unmodified cellular therapy products fail sustain bioenergetics tumors. We reveal imposes...
Abstract Intermittent fasting entails restricting food intake during specific times of day, days the week, religious practice, or surrounding clinically important events. Herein, metabolic and circadian rhythm mechanisms underlying proposed benefits intermittent for cancer population are described. We summarize epidemiological, preclinical, clinical studies in published between January 2020 August 2022 propose avenues future research. An outstanding concern regarding use among patients is...
Abstract The aggressive nature of pancreatic ductal adenocarcinoma (PDAC) mandates the development improved therapies. As KRAS mutations are found in 95% PDAC and critical for tumor maintenance, one promising strategy involves exploiting KRAS-dependent metabolic perturbations. macrometabolic process autophagy is upregulated KRAS-mutant PDAC, growth reliant on autophagy. However, inhibition as monotherapy using lysosomal inhibitor hydroxychloroquine (HCQ) has shown limited clinical efficacy....
Abstract Introduction Triple-negative breast cancer (TNBC), which tends to be more advanced when diagnosed and aggressive than other subtypes, is accelerated by obesity. Hypertrophic adipocytes cells exhibit increased oxidative stress altered redox homeostasis, influencing therapeutic outcomes. Enzymes implicated in both regulation TNBC include glutathione peroxidase 4 (GPX4; reduces lipid peroxides) pyruvate carboxylase (PC; essential protection). Using preclinical models, we characterized...
Abstract Background: Predictors of premature death and cancer development are needed to more precisely identify individuals who may warrant preventive intervention. Circulating IGF binding protein-7 (IGFBP7) and, lesser extent, the IGFBP7/IGF-1 ratio emerging biomarkers renal cardiovascular morbidity. However, their relationships with aging, obesity, mortality risk remain unclear. Methods: This hypothesis-generating study investigated plasma IGFBP7, IGF-1, as predictors all-cause mortality,...
Abstract The reversibility of the procancer effects obesity was interrogated in formerly obese C57BL/6 mice that lost weight via a nonrestricted low-fat diet (LFD) or 3 distinct calorie-restricted (CR) regimens (low-fat CR, Mediterranean-style intermittent CR). These mice, along with continuously and lean control were orthotopically injected E0771 cells, mouse model triple-negative breast cancer. Tumor weight, systemic cytokines, incidence lung metastases elevated LFD relative to CR groups....
Abstract We report for the first time an anticancer benefit of tirzepatide—a dual glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide receptor agonist—in a model obesity breast cancer in female mice. Long-term tirzepatide treatment induced weight loss, mitigated obesity-driven changes circulating metabolic hormone levels, suppressed orthotopic E0771 mammary tumor growth. Relative to tirzepatide, chronic calorie restriction, established intervention preclinical models,...
A full-term newborn infant had the onset of respiratory distress immediately after birth. She required supplemental oxygen from birth, and pulmonary alveolar proteinosis (PAP) documented by open lung biopsies at 6 12 weeks age. Light electron microscopy showed dense, PAS-positive granular, homogeneous material within spaces, diagnostic PAP. No Pneumocystic carinii organisms were demonstrated on silver staining, bacterial viral cultures negative. The died progressive insufficiency 1 yr...
Bilateral diaphragmatic pacing was successfully performed in an 18-month-old child with congenital central hypoventilation syndrome (Ondine9s curse) as alternative to long-term mechanical ventilation. Subsequent complications were related more cor pulmonale and tracheostomy care than the itself.
Obesity promotes triple-negative breast cancer (TNBC), and effective interventions are urgently needed to break the obesity-TNBC link. Epidemiologic studies indicate that bariatric surgery reduces TNBC risk, while evidence is limited or conflicted for weight loss via low-fat diet (LFD) calorie restriction (CR). Using a murine model of obesity-driven TNBC, we compared antitumor effects vertical sleeve gastrectomy (VSG) with LFD, chronic CR, intermittent CR. Each intervention generated fat...
Eight ventilator-dependent infants with bronchopulmonary dysplasia (BPD) were treated dexamethasone (0.5 mg/kg/day). Therapy was initiated at 19.3 ± 3.9 days of age, continued the initial dose for 7 days, then tapered over 2 weeks. The clinical course these BPD compared to that 8 similar ventilatordependent uncomplicated hyaline membrane disease (HMD). At study entry, patients had significantly higher ventilator rates, peak inspiratory pressures, mean airway alveolar-arterial oxygen...
Steinmuller, David1; Warden, Glenn1; Coleman, Michael1; Lofgreen, Jane1; Reemtsma, Keith1; Stuart, Frank2; Garrick, Thomas2; Holter, Arlen2; Lynch, Alison2 Author Information
Abstract Study Objectives Individuals with obstructive sleep apnea (OSA), characterized by frequent disruptions from tongue muscle relaxation and airway blockage, are known to benefit on-demand electrical stimulation of the hypoglossal nerve. Hypoglossal nerve (HNS) therapy, which activates protrusor muscles during inspiration, has been established in multiple clinical studies as safe effective, but mechanistic understanding for why some parameters work better than others not thoroughly...
ObjectiveOverweight/obesity is the strongest risk factor for endometrial cancer (EC), and weight management can reduce that improve survival. We aimed to establish differential benefits of intermittent energy restriction (IER) low-fat diet (LFD), alone in combination with paclitaxel, reverse procancer effects high-fat (HFD)-induced obesity a mouse model EC.MethodsLkb1fl/flp53fl/fl mice were fed HFD or LFD generate obese lean phenotypes, respectively. Obese maintained on switched (HFD-LFD)...
Triple-negative breast cancers (TNBCs), accounting for approximately 15% of cancers, lack targeted therapy. A hallmark cancer is metabolic reprogramming, with one-carbon metabolism essential to many processes altered in tumor cells, including nucleotide biosynthesis and antioxidant defenses. We reported that folate deficiency via folic acid (FA) withdrawal several TNBC cell lines results heterogenous effects on growth, mitochondrial impairment. To elucidate underlying drivers sensitivity...