A5007666288- Growth Hormone and Insulin-like Growth Factors
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
- Erythrocyte Function and Pathophysiology
- Wound Healing and Treatments
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Biosimilars and Bioanalytical Methods
- DNA Repair Mechanisms
- Polysaccharides and Plant Cell Walls
- Renal and related cancers
University College Cork
2018-2024
Klinikum rechts der Isar
2023-2024
Technical University of Munich
2023-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
University of Göttingen
2002
Penetration resistance represents the first level of plant defense against phytopathogenic fungi. Here, we report that starch-deficient Arabidopsis thaliana phosphoglucomutase (pgm) mutant has impaired penetration hemibiotrophic fungus Colletotrichum higginsianum. We could not determine any changes in leaf cutin and epicuticular wax composition or indolic glucosinolate levels, but detected complex alterations cell wall monosaccharide pgm. Notably, other mutants deficient starch biosynthesis...
Translocation of the IGF-1 receptor to Golgi promotes cancer cell migration.
B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model active RANK signaling the TCL1 oncogene, displaying both CLL phenotypes. In younger mice, expression expands CLL-like B1-lymphocytes, while originates from B2-cells, becoming predominant in later stages leading severe disease progression mortality. The induced mimics human disease, exhibiting features like...
Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized cancer treatment, with six CAR-T products currently in clinical use 1-4 . Despite their success, high resistance rates due to escape remain a major challenge 5,6 In silico design of de novo binders (DNBs) has the potential accelerate development new binding domains for CAR-T, possibly enabling personalized 7,8 Here, we show that DNBs can be used targeting clinically relevant antigens. Using DNB against epidermal growth...
Abstract Insulin-like Growth Factor-1 signaling has a well-described function in facilitating tumourigenesis and promoting tumour growth. Attempts to suppress IGF signals at the level of IGF-1 Receptor have been disappointing, with kinase inhibitors blocking antibodies generally showing poor efficacy clinical trials. To address mechanisms for this lack we sought identify proteins that modulate cytotoxic response IGF-1R tyrosine inhibition using functional siRNA screen. We identified...
Abstract Insulin-like Growth Factor-1 signaling facilitates tumorigenesis and promotes tumor growth by acting through its cell surface receptor (IGF-1R). Despite promising pre-clinical results, efforts to target the IGF1-1R in many different cancers have been largely unsuccessful, this remains un-explained. The IGF-1R shares significant sequence homology with Insulin (IR), most divergence C-terminal tail, which contains two tyrosines (Y1250/Y1251) that are not present IR. Previous studies...