A5019220175- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Physiological and biochemical adaptations
- Childhood Cancer Survivors' Quality of Life
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Growth Hormone and Insulin-like Growth Factors
- Animal Behavior and Reproduction
Pfizer (Austria)
2023
University of Vienna
2019-2021
Max Perutz Labs
2019-2021
Vienna Biocenter
2019-2021
University of Oxford
2018
Objective Defective mitochondrial function attributed to optic atrophy 1 ( OPA1 ) mutations causes primarily and, less commonly, neurodegenerative syndromes. The pathomechanism by which trigger diffuse loss of neurons in some, but not all, patients is unknown. Here, we used a tractable induced pluripotent stem cell (iPSC)‐based model capture the biology haploinsufficiency cases presenting with classic eye disease versus syndromic parkinsonism. Methods iPSCs were generated from 2 and controls...
Vertebrate behavior is strongly influenced by light. Light receptors, encoded functional opsin proteins, are present inside the vertebrate brain and peripheral tissues. This expression feature from fishes to human appears be particularly prominent in diurnal vertebrates. Despite their conserved widespread occurrence, nonvisual functions of opsins still largely enigmatic. even more apparent when considering high number opsins. Teleosts possess around 40 genes, young developmental stages...
One of the big challenges in study animal behavior is to combine molecular-level questions functional genetics with meaningful combinations environmental stimuli. Light and temperature are important external cues, influencing behaviors organisms. Thus, understanding combined effect light changes on wild-type vs. genetically modified animals a first step understand role individual genes ability cope changing environments. Many behavioral traits can be extrapolated from tests performed...
Abstract Vertebrate behavior is strongly influenced by light. Light receptors, encoded functional Opsin proteins, are present inside the vertebrate brain and peripheral tissues. This expression feature from fishes to human appears be particularly prominent in diurnal vertebrates. Despite their conserved widespread occurrence, non-visual functions of Opsins still largely enigmatic. even more apparent when considering high number Opsins. Teleosts possess around 40 genes, young developmental...
Zusammenfassung Rekombinantes humanes Wachstumshormon muss aufgrund seiner kurzen Halbwertszeit täglich injiziert werden. Dieses Behandlungsregime kann für Patient*innen und ihre Familien eine ganz erhebliche Belastung darstellen. Langwirksame Wachstumshormone (LAGH) sind neuartige Behandlungsoption, die durch 1‑mal wöchentliche Verabreichung reduzierte Injektionsfrequenz ermöglicht. Um erste Erkenntnisse über Erwartungen an diese neuen LAGH-Formulierungen zu gewinnen, wurden zwei Umfragen...